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Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine.

Publication ,  Journal Article
Serebruany, VL; Schlossberg, ML; Edenbaum, LR; Herzog, WR; Gurbel, PA
Published in: Int J Cardiol
August 29, 1997

Controversy currently exists regarding the use of diltiazem in the treatment of acute myocardial infarction (AMI). due to conflicting results from clinical trials and animal studies. The purpose of this project was to evaluate the changes in the hemostatic profile during AMI following low dose intracoronary diltiazem infusion. Fourteen Yorkshire swine underwent thoracotomy and 50 min LAD occlusion, followed by 3 h of reperfusion. The first group (n = 8) received 2.5 mg of diltiazem intracoronary at a rate of 5.6 micrograms kg min-1 at the onset of reperfusion. The second group (n = 6) received 0.9% saline intracoronary at the onset of reperfusion and served as the control. The dynamics of plasma antithrombin-III (AT-III), Protein C, total Protein S, fibronectin, endothelin-1 (ET-1), and the stable metabolites of thromboxane (TxB2) and prostacyclin (6-keto-PGF1a) were determined at baseline, then twice during occlusion and finally three times during reperfusion. Diltiazem infusion resulted in diminished ET-1 (34.5%), fibronectin (23.2%), and TxB2 (35.6%); and elevated Protein C (29.3%) when compared with controls. We conclude that intracoronary diltiazem favorable influences hemostasis during AMI in swine. The cardioprotective effects of diltiazem during AMI may be related to the improved hemostatic profile and the reduced incidence of thrombotic complications in such patients.

Duke Scholars

Published In

Int J Cardiol

DOI

ISSN

0167-5273

Publication Date

August 29, 1997

Volume

61

Issue

1

Start / End Page

21 / 29

Location

Netherlands

Related Subject Headings

  • Swine
  • Myocardial Infarction
  • Infusions, Intra-Arterial
  • Hemostasis
  • Fibronectins
  • Female
  • Endothelin-1
  • Eicosanoids
  • Disease Models, Animal
  • Diltiazem
 

Citation

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Serebruany, V. L., Schlossberg, M. L., Edenbaum, L. R., Herzog, W. R., & Gurbel, P. A. (1997). Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine. Int J Cardiol, 61(1), 21–29. https://doi.org/10.1016/s0167-5273(97)00111-3
Serebruany, V. L., M. L. Schlossberg, L. R. Edenbaum, W. R. Herzog, and P. A. Gurbel. “Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine.Int J Cardiol 61, no. 1 (August 29, 1997): 21–29. https://doi.org/10.1016/s0167-5273(97)00111-3.
Serebruany VL, Schlossberg ML, Edenbaum LR, Herzog WR, Gurbel PA. Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine. Int J Cardiol. 1997 Aug 29;61(1):21–9.
Serebruany, V. L., et al. “Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine.Int J Cardiol, vol. 61, no. 1, Aug. 1997, pp. 21–29. Pubmed, doi:10.1016/s0167-5273(97)00111-3.
Serebruany VL, Schlossberg ML, Edenbaum LR, Herzog WR, Gurbel PA. Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine. Int J Cardiol. 1997 Aug 29;61(1):21–29.
Journal cover image

Published In

Int J Cardiol

DOI

ISSN

0167-5273

Publication Date

August 29, 1997

Volume

61

Issue

1

Start / End Page

21 / 29

Location

Netherlands

Related Subject Headings

  • Swine
  • Myocardial Infarction
  • Infusions, Intra-Arterial
  • Hemostasis
  • Fibronectins
  • Female
  • Endothelin-1
  • Eicosanoids
  • Disease Models, Animal
  • Diltiazem