Skip to main content

Mild myocardial stunning affects platelet aggregation and hemostasis in swine

Publication ,  Journal Article
Serebruany, VL; Herzog, WR; Gurbel, PA
Published in: FASEB Journal
December 1, 1996

The key role of platelet activation and hemostatic disorders have been increasingly recognized in patients with unstable angina and acute myocardial infarction. However, the dynamics of the hemostatic profile during brief ischemia-reperfusion are poorly understood and may contribute to the pathogenesis of myocardial stunning (MS). The purpose of current study was to investigate the serial changes of platelet aggregation and hemostatic profile during occlusion and reperfusion of mild MS using an in vivo animal model. Nine open-chested Yorkshire swine underwent coronary artery occlusion for 8 minutes followed by 90 minutes of reperfusion. Blood samples were obtained at baseline, at 4 and at B minutes of occlusion, and at 60 and 90 minutes of reperfusion. Platelet aggregability and concentrations of antithrombin-lll (AT-III), Protein C, Protein S, ftoronectin, endothelin-1 (ET-1), as well as the stable metabolites of thromboxane (TxB2) and prostacyclin (6-keto- PGF1a), were measured in the systemic circulation. The occlusion phase of MS was associated with a decline of ET-1 (-13.6%), TxB2 (-19.6%); and elevation of AT-III (+40.2%) and Prolein C (+22.9%). Short-term ischemia-reperfusion resulted in significant increase of platelet aggregation (+33.7%), ET-1 (+24.7%), 6-keto-PGFia (+41.5%), TxB2 (+11.9%) and Protein C (+42.3%) during the reperfusion phase. There were no significant changes in fibronectin and total Protein S levels. We conclude that mild MS is associated with substantial dynamic changes in platelet aggregability and the hemostatic profile. This data provides support for the involvement of cellular mechanisms and endothelial dysfunction in the pathogenesis of MS. Further investigation is warranted.

Duke Scholars

Published In

FASEB Journal

ISSN

0892-6638

Publication Date

December 1, 1996

Volume

10

Issue

3

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 3208 Medical physiology
  • 3101 Biochemistry and cell biology
  • 1116 Medical Physiology
  • 0606 Physiology
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Serebruany, V. L., Herzog, W. R., & Gurbel, P. A. (1996). Mild myocardial stunning affects platelet aggregation and hemostasis in swine. FASEB Journal, 10(3).
Serebruany, V. L., W. R. Herzog, and P. A. Gurbel. “Mild myocardial stunning affects platelet aggregation and hemostasis in swine.” FASEB Journal 10, no. 3 (December 1, 1996).
Serebruany VL, Herzog WR, Gurbel PA. Mild myocardial stunning affects platelet aggregation and hemostasis in swine. FASEB Journal. 1996 Dec 1;10(3).
Serebruany, V. L., et al. “Mild myocardial stunning affects platelet aggregation and hemostasis in swine.” FASEB Journal, vol. 10, no. 3, Dec. 1996.
Serebruany VL, Herzog WR, Gurbel PA. Mild myocardial stunning affects platelet aggregation and hemostasis in swine. FASEB Journal. 1996 Dec 1;10(3).

Published In

FASEB Journal

ISSN

0892-6638

Publication Date

December 1, 1996

Volume

10

Issue

3

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 3208 Medical physiology
  • 3101 Biochemistry and cell biology
  • 1116 Medical Physiology
  • 0606 Physiology
  • 0601 Biochemistry and Cell Biology