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Hypofractionation for clinically localized prostate cancer.

Publication ,  Journal Article
Cabrera, AR; Lee, WR
Published in: Semin Radiat Oncol
July 2013

This manuscript reviews the clinical evidence for hypofractionation in prostate cancer, focusing on data from prospective trials. For the purposes of this manuscript, we categorize hypofractionation as moderate (2.4-4 Gy per fraction) or extreme (6.5-10 Gy per fraction). Five randomized controlled trials have evaluated moderate hypofractionation in >1500 men, with most followed for >4-5 years. The results of these randomized trials are inconsistent. No randomized trials or other rigorous comparisons of extreme hypofractionation with conventional fractionation have been reported. Prospective single-arm studies of extreme hypofractionation appear favorable, but small sample sizes preclude precise estimates of efficacy and short follow-up prevents complication estimates beyond 3-5 years. Over the next several years, the results of 3 large noninferiority trials of moderate hypofractionation and 2 randomized trials of extreme hypofractionation should help clarify the role of hypofractionation in prostate cancer therapy.

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Published In

Semin Radiat Oncol

DOI

EISSN

1532-9461

Publication Date

July 2013

Volume

23

Issue

3

Start / End Page

191 / 197

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • Dose Fractionation, Radiation
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Cabrera, A. R., & Lee, W. R. (2013). Hypofractionation for clinically localized prostate cancer. Semin Radiat Oncol, 23(3), 191–197. https://doi.org/10.1016/j.semradonc.2013.01.005
Cabrera, Alvin R., and W Robert Lee. “Hypofractionation for clinically localized prostate cancer.Semin Radiat Oncol 23, no. 3 (July 2013): 191–97. https://doi.org/10.1016/j.semradonc.2013.01.005.
Cabrera AR, Lee WR. Hypofractionation for clinically localized prostate cancer. Semin Radiat Oncol. 2013 Jul;23(3):191–7.
Cabrera, Alvin R., and W. Robert Lee. “Hypofractionation for clinically localized prostate cancer.Semin Radiat Oncol, vol. 23, no. 3, July 2013, pp. 191–97. Pubmed, doi:10.1016/j.semradonc.2013.01.005.
Cabrera AR, Lee WR. Hypofractionation for clinically localized prostate cancer. Semin Radiat Oncol. 2013 Jul;23(3):191–197.
Journal cover image

Published In

Semin Radiat Oncol

DOI

EISSN

1532-9461

Publication Date

July 2013

Volume

23

Issue

3

Start / End Page

191 / 197

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • Dose Fractionation, Radiation
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis