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In-hospital and 1-year outcomes among percutaneous coronary intervention patients with chronic kidney disease in the era of drug-eluting stents: a report from the EVENT (Evaluation of Drug Eluting Stents and Ischemic Events) registry.

Publication ,  Journal Article
Latif, F; Kleiman, NS; Cohen, DJ; Pencina, MJ; Yen, C-H; Cutlip, DE; Moliterno, DJ; Nassif, D; Lopez, JJ; Saucedo, JF; EVENT Investigators,
Published in: JACC Cardiovasc Interv
January 2009

OBJECTIVES: This study sought to evaluate ischemic and bleeding outcomes in patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). BACKGROUND: Previous studies have shown that CKD is associated with poor outcomes after PCI. However, these studies were largely conducted before the introduction of DES and aggressive antithrombotic therapy or were performed in the setting of randomized trials. With data from a contemporary registry, we evaluated the influence of CKD on major cardiovascular events and bleeding complications in unselected "real-world" patients undergoing PCI. METHODS: Data from 4,791 patients enrolled in the EVENT (Evaluation of Drug Eluting Stents and Ischemic Events) Registry between July 2004 and September 2005 were analyzed. Patients were stratified into 4 groups: creatinine clearance (CrCl) >75, 50 to 75, 30 to 49 and <30 ml/min. RESULTS: During the index hospital stay, there was a step-wise increase in bleeding complications with decreasing CrCl (3.3%, 5.0%, 8.8%, and 14.3%; p < 0.0001 for trend). Lower CrCl was also associated with more frequent death or myocardial infarction (MI) during the initial hospital stay (p = 0.001) and at 1 year (p < 0.001). These findings were confirmed in multivariate analyses that adjusted for baseline differences in demographic, clinical, and angiographic factors. Use of guideline-recommended medications at 1 year, including aspirin, clopidogrel, angiotensin-converting enzyme inhibitors, and statins, also decreased with declining renal function. CONCLUSIONS: Renal function is an independent and powerful predictor of bleeding and ischemic complications in the era of DES and contemporary antithrombotic therapy in patients undergoing PCI. The low use of guideline-recommended drugs among patients with CKD undergoing PCI might contribute to these adverse outcomes and warrants further evaluation.

Duke Scholars

Published In

JACC Cardiovasc Interv

DOI

EISSN

1876-7605

Publication Date

January 2009

Volume

2

Issue

1

Start / End Page

37 / 45

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Registries
  • Myocardial Ischemia
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
  • Inpatients
  • Humans
 

Citation

APA
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ICMJE
MLA
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Latif, F., Kleiman, N. S., Cohen, D. J., Pencina, M. J., Yen, C.-H., Cutlip, D. E., … EVENT Investigators, . (2009). In-hospital and 1-year outcomes among percutaneous coronary intervention patients with chronic kidney disease in the era of drug-eluting stents: a report from the EVENT (Evaluation of Drug Eluting Stents and Ischemic Events) registry. JACC Cardiovasc Interv, 2(1), 37–45. https://doi.org/10.1016/j.jcin.2008.06.012
Latif, Faisal, Neal S. Kleiman, David J. Cohen, Michael J. Pencina, Chen-Hsing Yen, Donald E. Cutlip, David J. Moliterno, et al. “In-hospital and 1-year outcomes among percutaneous coronary intervention patients with chronic kidney disease in the era of drug-eluting stents: a report from the EVENT (Evaluation of Drug Eluting Stents and Ischemic Events) registry.JACC Cardiovasc Interv 2, no. 1 (January 2009): 37–45. https://doi.org/10.1016/j.jcin.2008.06.012.
Latif F, Kleiman NS, Cohen DJ, Pencina MJ, Yen C-H, Cutlip DE, Moliterno DJ, Nassif D, Lopez JJ, Saucedo JF, EVENT Investigators. In-hospital and 1-year outcomes among percutaneous coronary intervention patients with chronic kidney disease in the era of drug-eluting stents: a report from the EVENT (Evaluation of Drug Eluting Stents and Ischemic Events) registry. JACC Cardiovasc Interv. 2009 Jan;2(1):37–45.
Journal cover image

Published In

JACC Cardiovasc Interv

DOI

EISSN

1876-7605

Publication Date

January 2009

Volume

2

Issue

1

Start / End Page

37 / 45

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Registries
  • Myocardial Ischemia
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
  • Inpatients
  • Humans