MicroRNA target site identification by integrating sequence and binding information
Publication
, Journal Article
Majoros, WH; Lekprasert, P; Mukherjee, N; Skalsky, RL; Corcoran, DL; Cullen, BR; Ohler, U
Published in: Nature Methods
May 26, 2013
High-throughput sequencing has opened numerous possibilities for the identification of regulatory RNA-binding events. Cross-linking and immunoprecipitation of Argonaute proteins can pinpoint a microRNA (miRNA) target site within tens of bases but leaves the identity of the miRNA unresolved. A flexible computational framework, microMUMMIE, integrates sequence with cross-linking features and reliably identifies the miRNA family involved in each binding event. It considerably outperforms sequence-only approaches and quantifies the prevalence of noncanonical binding modes.
Duke Scholars
Published In
Nature Methods
DOI
EISSN
1548-7105
ISSN
1548-7091
Publication Date
May 26, 2013
Related Subject Headings
- Developmental Biology
- 11 Medical and Health Sciences
- 10 Technology
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Majoros, W. H., Lekprasert, P., Mukherjee, N., Skalsky, R. L., Corcoran, D. L., Cullen, B. R., & Ohler, U. (2013). MicroRNA target site identification by integrating sequence and binding information (Accepted). Nature Methods. https://doi.org/10.138/nmeth.2489
Majoros, W. H., P. Lekprasert, N. Mukherjee, R. L. Skalsky, D. L. Corcoran, B. R. Cullen, and U. Ohler. “MicroRNA target site identification by integrating sequence and binding information (Accepted).” Nature Methods, May 26, 2013. https://doi.org/10.138/nmeth.2489.
Majoros WH, Lekprasert P, Mukherjee N, Skalsky RL, Corcoran DL, Cullen BR, et al. MicroRNA target site identification by integrating sequence and binding information (Accepted). Nature Methods. 2013 May 26;
Majoros, W. H., et al. “MicroRNA target site identification by integrating sequence and binding information (Accepted).” Nature Methods, May 2013. Scopus, doi:10.138/nmeth.2489.
Majoros WH, Lekprasert P, Mukherjee N, Skalsky RL, Corcoran DL, Cullen BR, Ohler U. MicroRNA target site identification by integrating sequence and binding information (Accepted). Nature Methods. 2013 May 26;
Published In
Nature Methods
DOI
EISSN
1548-7105
ISSN
1548-7091
Publication Date
May 26, 2013
Related Subject Headings
- Developmental Biology
- 11 Medical and Health Sciences
- 10 Technology
- 06 Biological Sciences