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Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.

Publication ,  Journal Article
Jones, LW; Fels, DR; West, M; Allen, JD; Broadwater, G; Barry, WT; Wilke, LG; Masko, E; Douglas, PS; Dash, RC; Povsic, TJ; Peppercorn, J ...
Published in: Cancer Prev Res (Phila)
September 2013

Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts with the antitumor efficacy of chemotherapy has received scant attention. We carried out a pilot study to explore the effects of AET in combination with neoadjuvant doxorubicin-cyclophosphamide (AC+AET), relative to AC alone, on: (i) host physiology [exercise capacity (VO2 peak), brachial artery flow-mediated dilation (BA-FMD)], (ii) host-related circulating factors [circulating endothelial progenitor cells (CEP) cytokines and angiogenic factors (CAF)], and (iii) tumor phenotype [tumor blood flow ((15)O-water PET), tissue markers (hypoxia and proliferation), and gene expression] in 20 women with operable breast cancer. AET consisted of three supervised cycle ergometry sessions/week at 60% to 100% of VO2 peak, 30 to 45 min/session, for 12 weeks. There was significant time × group interactions for VO2 peak and BA-FMD, favoring the AC+AET group (P < 0.001 and P = 0.07, respectively). These changes were accompanied by significant time × group interactions in CEPs and select CAFs [placenta growth factor, interleukin (IL)-1β, and IL-2], also favoring the AC+AET group (P < 0.05). (15)O-water positron emission tomography (PET) imaging revealed a 38% decrease in tumor blood flow in the AC+AET group. There were no differences in any tumor tissue markers (P > 0.05). Whole-genome microarray tumor analysis revealed significant differential modulation of 57 pathways (P < 0.01), including many that converge on NF-κB. Data from this exploratory study provide initial evidence that AET can modulate several host- and tumor-related pathways during standard chemotherapy. The biologic and clinical implications remain to be determined.

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Published In

Cancer Prev Res (Phila)

DOI

EISSN

1940-6215

Publication Date

September 2013

Volume

6

Issue

9

Start / End Page

925 / 937

Location

United States

Related Subject Headings

  • Stem Cells
  • Reverse Transcriptase Polymerase Chain Reaction
  • Real-Time Polymerase Chain Reaction
  • RNA, Messenger
  • Prognosis
  • Oncology & Carcinogenesis
  • Oligonucleotide Array Sequence Analysis
  • Neovascularization, Pathologic
  • Neoplasm Staging
  • Neoadjuvant Therapy
 

Citation

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Jones, L. W., Fels, D. R., West, M., Allen, J. D., Broadwater, G., Barry, W. T., … Dewhirst, M. W. (2013). Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prev Res (Phila), 6(9), 925–937. https://doi.org/10.1158/1940-6207.CAPR-12-0416
Jones, Lee W., Diane R. Fels, Miranda West, Jason D. Allen, Gloria Broadwater, William T. Barry, Lee G. Wilke, et al. “Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.Cancer Prev Res (Phila) 6, no. 9 (September 2013): 925–37. https://doi.org/10.1158/1940-6207.CAPR-12-0416.
Jones LW, Fels DR, West M, Allen JD, Broadwater G, Barry WT, et al. Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prev Res (Phila). 2013 Sep;6(9):925–37.
Jones, Lee W., et al. “Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.Cancer Prev Res (Phila), vol. 6, no. 9, Sept. 2013, pp. 925–37. Pubmed, doi:10.1158/1940-6207.CAPR-12-0416.
Jones LW, Fels DR, West M, Allen JD, Broadwater G, Barry WT, Wilke LG, Masko E, Douglas PS, Dash RC, Povsic TJ, Peppercorn J, Marcom PK, Blackwell KL, Kimmick G, Turkington TG, Dewhirst MW. Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prev Res (Phila). 2013 Sep;6(9):925–937.

Published In

Cancer Prev Res (Phila)

DOI

EISSN

1940-6215

Publication Date

September 2013

Volume

6

Issue

9

Start / End Page

925 / 937

Location

United States

Related Subject Headings

  • Stem Cells
  • Reverse Transcriptase Polymerase Chain Reaction
  • Real-Time Polymerase Chain Reaction
  • RNA, Messenger
  • Prognosis
  • Oncology & Carcinogenesis
  • Oligonucleotide Array Sequence Analysis
  • Neovascularization, Pathologic
  • Neoplasm Staging
  • Neoadjuvant Therapy