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Strategies for optimizing the response of cancer and normal tissues to radiation.

Publication ,  Journal Article
Moding, EJ; Kastan, MB; Kirsch, DG
Published in: Nat Rev Drug Discov
July 2013

Approximately 50% of all patients with cancer receive radiation therapy at some point during the course of their treatment, and the majority of these patients are treated with curative intent. Despite recent advances in the planning of radiation treatment and the delivery of image-guided radiation therapy, acute toxicity and potential long-term side effects often limit the ability to deliver a sufficient dose of radiation to control tumours locally. In the past two decades, a better understanding of the hallmarks of cancer and the discovery of specific signalling pathways by which cells respond to radiation have provided new opportunities to design molecularly targeted therapies to increase the therapeutic window of radiation therapy. Here, we review efforts to develop approaches that could improve outcomes with radiation therapy by increasing the probability of tumour cure or by decreasing normal tissue toxicity.

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Published In

Nat Rev Drug Discov

DOI

EISSN

1474-1784

Publication Date

July 2013

Volume

12

Issue

7

Start / End Page

526 / 542

Location

England

Related Subject Headings

  • Radiotherapy, Intensity-Modulated
  • Radiotherapy, Image-Guided
  • Radiation-Sensitizing Agents
  • Radiation-Protective Agents
  • Radiation Dosage
  • Pharmacology & Pharmacy
  • Neoplasms
  • Humans
  • Dose-Response Relationship, Radiation
  • Chemoradiotherapy
 

Citation

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Moding, E. J., Kastan, M. B., & Kirsch, D. G. (2013). Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov, 12(7), 526–542. https://doi.org/10.1038/nrd4003
Moding, Everett J., Michael B. Kastan, and David G. Kirsch. “Strategies for optimizing the response of cancer and normal tissues to radiation.Nat Rev Drug Discov 12, no. 7 (July 2013): 526–42. https://doi.org/10.1038/nrd4003.
Moding EJ, Kastan MB, Kirsch DG. Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov. 2013 Jul;12(7):526–42.
Moding, Everett J., et al. “Strategies for optimizing the response of cancer and normal tissues to radiation.Nat Rev Drug Discov, vol. 12, no. 7, July 2013, pp. 526–42. Pubmed, doi:10.1038/nrd4003.
Moding EJ, Kastan MB, Kirsch DG. Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov. 2013 Jul;12(7):526–542.

Published In

Nat Rev Drug Discov

DOI

EISSN

1474-1784

Publication Date

July 2013

Volume

12

Issue

7

Start / End Page

526 / 542

Location

England

Related Subject Headings

  • Radiotherapy, Intensity-Modulated
  • Radiotherapy, Image-Guided
  • Radiation-Sensitizing Agents
  • Radiation-Protective Agents
  • Radiation Dosage
  • Pharmacology & Pharmacy
  • Neoplasms
  • Humans
  • Dose-Response Relationship, Radiation
  • Chemoradiotherapy