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Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF.

Publication ,  Journal Article
Agostino, PV; Cheng, R-K; Williams, CL; West, AE; Meck, WH
Published in: Genes Brain Behav
August 2013

Interval timing within the seconds-to-minutes range involves the interaction of the prefrontal cortex and basal ganglia via dopaminergic-glutamatergic pathways. Because the secreted protein brain-derived neurotrophic factor (BDNF) is able to modulate dopamine release as well as glutamatergic activity, we hypothesized that BDNF may be important for these timing mechanisms. Recently, the calcium-responsive transcription factor (CaRF) was identified as an important modulator of BDNF expression in the cerebral cortex. In this study, a strain of Carf knockout mice was evaluated for their ability to acquire the 'Start' and 'Stop' response thresholds under sequential and simultaneous training conditions, using multiple (15-second and 45-second) or single (30-second) target durations in the peak-interval procedure. Both Carf(+/-) and Carf(-/-) mice were impaired in their ability to acquire timed response thresholds relative to Carf(+/+) mice. Additionally, control mice given microinjections of BDNF antisense oligodeoxynucleotide to inhibit protein expression in the prefrontal cortex showed timing impairments during acquisition similar to Carf mice. Together, these results suggest that the inhibitory processes required to update response thresholds and exert temporal control of behavior during acquisition may be dependent on CaRF regulation of genes including Bdnf in cortico-striatal circuits.

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Published In

Genes Brain Behav

DOI

EISSN

1601-183X

Publication Date

August 2013

Volume

12

Issue

6

Start / End Page

633 / 644

Location

England

Related Subject Headings

  • Transcription Factors
  • Time Perception
  • Reaction Time
  • Prefrontal Cortex
  • Neurology & Neurosurgery
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Conditioning, Classical
 

Citation

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Agostino, P. V., Cheng, R.-K., Williams, C. L., West, A. E., & Meck, W. H. (2013). Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. Genes Brain Behav, 12(6), 633–644. https://doi.org/10.1111/gbb.12059
Agostino, P. V., R. -. K. Cheng, C. L. Williams, A. E. West, and W. H. Meck. “Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF.Genes Brain Behav 12, no. 6 (August 2013): 633–44. https://doi.org/10.1111/gbb.12059.
Agostino PV, Cheng R-K, Williams CL, West AE, Meck WH. Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. Genes Brain Behav. 2013 Aug;12(6):633–44.
Agostino, P. V., et al. “Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF.Genes Brain Behav, vol. 12, no. 6, Aug. 2013, pp. 633–44. Pubmed, doi:10.1111/gbb.12059.
Agostino PV, Cheng R-K, Williams CL, West AE, Meck WH. Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. Genes Brain Behav. 2013 Aug;12(6):633–644.
Journal cover image

Published In

Genes Brain Behav

DOI

EISSN

1601-183X

Publication Date

August 2013

Volume

12

Issue

6

Start / End Page

633 / 644

Location

England

Related Subject Headings

  • Transcription Factors
  • Time Perception
  • Reaction Time
  • Prefrontal Cortex
  • Neurology & Neurosurgery
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Conditioning, Classical