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Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.

Publication ,  Journal Article
Carr, G; Derbyshire, ER; Caldera, E; Currie, CR; Clardy, J
Published in: Journal of natural products
October 2012

Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.

Duke Scholars

Published In

Journal of natural products

DOI

EISSN

1520-6025

ISSN

0163-3864

Publication Date

October 2012

Volume

75

Issue

10

Start / End Page

1806 / 1809

Related Subject Headings

  • Symbiosis
  • Sporozoites
  • Saccharomyces cerevisiae
  • Plasmodium berghei
  • Microbial Sensitivity Tests
  • Medicinal & Biomolecular Chemistry
  • Liver
  • Humans
  • Hep G2 Cells
  • Escherichia coli
 

Citation

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Carr, G., Derbyshire, E. R., Caldera, E., Currie, C. R., & Clardy, J. (2012). Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of Natural Products, 75(10), 1806–1809. https://doi.org/10.1021/np300380t
Carr, Gavin, Emily R. Derbyshire, Eric Caldera, Cameron R. Currie, and Jon Clardy. “Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.Journal of Natural Products 75, no. 10 (October 2012): 1806–9. https://doi.org/10.1021/np300380t.
Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of natural products. 2012 Oct;75(10):1806–9.
Carr, Gavin, et al. “Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.Journal of Natural Products, vol. 75, no. 10, Oct. 2012, pp. 1806–09. Epmc, doi:10.1021/np300380t.
Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of natural products. 2012 Oct;75(10):1806–1809.
Journal cover image

Published In

Journal of natural products

DOI

EISSN

1520-6025

ISSN

0163-3864

Publication Date

October 2012

Volume

75

Issue

10

Start / End Page

1806 / 1809

Related Subject Headings

  • Symbiosis
  • Sporozoites
  • Saccharomyces cerevisiae
  • Plasmodium berghei
  • Microbial Sensitivity Tests
  • Medicinal & Biomolecular Chemistry
  • Liver
  • Humans
  • Hep G2 Cells
  • Escherichia coli