MicroRNA target site identification by integrating sequence and binding information
Publication
, Journal Article
Majoros, WH; Lekprasert, P; Mukherjee, N; Skalsky, RL; Corcoran, DL; Cullen, BR; Ohler, U
Published in: Nature Methods
2013
High-throughput sequencing has opened numerous possibilities for the identification of regulatory RNA-binding events. Cross-linking and immunoprecipitation of Argonaute proteins can pinpoint a microRNA (miRNA) target site within tens of bases but leaves the identity of the miRNA unresolved. A flexible computational framework, microMUMMIE, integrates sequence with cross-linking features and reliably identifies the miRNA family involved in each binding event. It considerably outperforms sequence-only approaches and quantifies the prevalence of noncanonical binding modes. © 2013 Nature America, Inc. All rights reserved.
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Published In
Nature Methods
DOI
ISSN
1548-7091
Publication Date
2013
Volume
10
Issue
7
Start / End Page
630 / 633
Related Subject Headings
- Developmental Biology
- 11 Medical and Health Sciences
- 10 Technology
- 06 Biological Sciences
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Majoros, W. H., Lekprasert, P., Mukherjee, N., Skalsky, R. L., Corcoran, D. L., Cullen, B. R., & Ohler, U. (2013). MicroRNA target site identification by integrating sequence and binding information. Nature Methods, 10(7), 630–633. https://doi.org/10.1038/nmeth.2489
Majoros, W. H., P. Lekprasert, N. Mukherjee, R. L. Skalsky, D. L. Corcoran, B. R. Cullen, and U. Ohler. “MicroRNA target site identification by integrating sequence and binding information.” Nature Methods 10, no. 7 (2013): 630–33. https://doi.org/10.1038/nmeth.2489.
Majoros WH, Lekprasert P, Mukherjee N, Skalsky RL, Corcoran DL, Cullen BR, et al. MicroRNA target site identification by integrating sequence and binding information. Nature Methods. 2013;10(7):630–3.
Majoros, W. H., et al. “MicroRNA target site identification by integrating sequence and binding information.” Nature Methods, vol. 10, no. 7, 2013, pp. 630–33. Scival, doi:10.1038/nmeth.2489.
Majoros WH, Lekprasert P, Mukherjee N, Skalsky RL, Corcoran DL, Cullen BR, Ohler U. MicroRNA target site identification by integrating sequence and binding information. Nature Methods. 2013;10(7):630–633.
Published In
Nature Methods
DOI
ISSN
1548-7091
Publication Date
2013
Volume
10
Issue
7
Start / End Page
630 / 633
Related Subject Headings
- Developmental Biology
- 11 Medical and Health Sciences
- 10 Technology
- 06 Biological Sciences