Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.
Publication
, Journal Article
Sandlund, JT; Hudson, MM; Kennedy, W; Onciu, M; Kastan, MB
Published in: Pediatr Blood Cancer
February 2014
Children with ataxia-telangiectasia (A-T) and cancer have a poorer prognosis due in part to increased treatment-related toxicity. We piloted a curative intent approach in five children with A-T who presented with advanced stage (III, n = 2; IV, n = 3) B-NHL (diffuse large B-cell lymphoma, n = 4; Burkitt leukemia, n = 1) using a modified LMB-based protocol. Two achieved sustained CCR (one, CCR at 6 years; one, pulmonary death after 3 years in CCR). Two died from toxicity during induction and 1 failed induction with progressive disease. Novel therapeutic approaches which overcome drug resistance and are less toxic are needed for children with A-T and B-NHL.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Pediatr Blood Cancer
DOI
EISSN
1545-5017
Publication Date
February 2014
Volume
61
Issue
2
Start / End Page
360 / 362
Location
United States
Related Subject Headings
- Young Adult
- Vincristine
- Prospective Studies
- Prognosis
- Prednisone
- Pilot Projects
- Oncology & Carcinogenesis
- Neoplasm Staging
- Methotrexate
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Sandlund, J. T., Hudson, M. M., Kennedy, W., Onciu, M., & Kastan, M. B. (2014). Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies. Pediatr Blood Cancer, 61(2), 360–362. https://doi.org/10.1002/pbc.24696
Sandlund, J. T., M. M. Hudson, W. Kennedy, M. Onciu, and M. B. Kastan. “Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.” Pediatr Blood Cancer 61, no. 2 (February 2014): 360–62. https://doi.org/10.1002/pbc.24696.
Sandlund JT, Hudson MM, Kennedy W, Onciu M, Kastan MB. Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies. Pediatr Blood Cancer. 2014 Feb;61(2):360–2.
Sandlund, J. T., et al. “Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.” Pediatr Blood Cancer, vol. 61, no. 2, Feb. 2014, pp. 360–62. Pubmed, doi:10.1002/pbc.24696.
Sandlund JT, Hudson MM, Kennedy W, Onciu M, Kastan MB. Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies. Pediatr Blood Cancer. 2014 Feb;61(2):360–362.
Published In
Pediatr Blood Cancer
DOI
EISSN
1545-5017
Publication Date
February 2014
Volume
61
Issue
2
Start / End Page
360 / 362
Location
United States
Related Subject Headings
- Young Adult
- Vincristine
- Prospective Studies
- Prognosis
- Prednisone
- Pilot Projects
- Oncology & Carcinogenesis
- Neoplasm Staging
- Methotrexate
- Male