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Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.

Publication ,  Journal Article
Sandlund, JT; Hudson, MM; Kennedy, W; Onciu, M; Kastan, MB
Published in: Pediatr Blood Cancer
February 2014

Children with ataxia-telangiectasia (A-T) and cancer have a poorer prognosis due in part to increased treatment-related toxicity. We piloted a curative intent approach in five children with A-T who presented with advanced stage (III, n = 2; IV, n = 3) B-NHL (diffuse large B-cell lymphoma, n = 4; Burkitt leukemia, n = 1) using a modified LMB-based protocol. Two achieved sustained CCR (one, CCR at 6 years; one, pulmonary death after 3 years in CCR). Two died from toxicity during induction and 1 failed induction with progressive disease. Novel therapeutic approaches which overcome drug resistance and are less toxic are needed for children with A-T and B-NHL.

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Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

February 2014

Volume

61

Issue

2

Start / End Page

360 / 362

Location

United States

Related Subject Headings

  • Young Adult
  • Vincristine
  • Prospective Studies
  • Prognosis
  • Prednisone
  • Pilot Projects
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Methotrexate
  • Male
 

Citation

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Sandlund, J. T., Hudson, M. M., Kennedy, W., Onciu, M., & Kastan, M. B. (2014). Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies. Pediatr Blood Cancer, 61(2), 360–362. https://doi.org/10.1002/pbc.24696
Sandlund, J. T., M. M. Hudson, W. Kennedy, M. Onciu, and M. B. Kastan. “Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.Pediatr Blood Cancer 61, no. 2 (February 2014): 360–62. https://doi.org/10.1002/pbc.24696.
Sandlund JT, Hudson MM, Kennedy W, Onciu M, Kastan MB. Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies. Pediatr Blood Cancer. 2014 Feb;61(2):360–2.
Sandlund, J. T., et al. “Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.Pediatr Blood Cancer, vol. 61, no. 2, Feb. 2014, pp. 360–62. Pubmed, doi:10.1002/pbc.24696.
Sandlund JT, Hudson MM, Kennedy W, Onciu M, Kastan MB. Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies. Pediatr Blood Cancer. 2014 Feb;61(2):360–362.
Journal cover image

Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

February 2014

Volume

61

Issue

2

Start / End Page

360 / 362

Location

United States

Related Subject Headings

  • Young Adult
  • Vincristine
  • Prospective Studies
  • Prognosis
  • Prednisone
  • Pilot Projects
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Methotrexate
  • Male