Prenatal sensitization of a postnatal trigger for metabolic disease.
Publication
, Journal Article
Murphy, SK
Published in: J Clin Invest
July 2013
Intrahepatic cholestasis of pregnancy (ICP), marked by elevated maternal serum bile acid levels, occurs in late pregnancy and is often associated with poor perinatal outcomes. In this issue of the JCI, Papacleovoulou et al. analyze the long-term consequences of ICP and find that teens born to mothers with ICP exhibit enhanced characteristics of metabolic syndrome relative to controls. The authors also used a new ICP mouse model to support and extend these findings, demonstrating that in utero exposure to bile acids induces persistent epigenetic alterations and abnormal placental lipogenesis,setting the stage for later metabolic dysfunction.
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Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
July 2013
Volume
123
Issue
7
Start / End Page
2786 / 2788
Location
United States
Related Subject Headings
- Prenatal Exposure Delayed Effects
- Pregnancy Complications
- Pregnancy
- Obesity
- Male
- Immunology
- Humans
- Female
- Fatty Liver
- Cholestasis, Intrahepatic
Citation
APA
Chicago
ICMJE
MLA
NLM
Murphy, S. K. (2013). Prenatal sensitization of a postnatal trigger for metabolic disease. J Clin Invest, 123(7), 2786–2788. https://doi.org/10.1172/JCI69399
Murphy, Susan K. “Prenatal sensitization of a postnatal trigger for metabolic disease.” J Clin Invest 123, no. 7 (July 2013): 2786–88. https://doi.org/10.1172/JCI69399.
Murphy SK. Prenatal sensitization of a postnatal trigger for metabolic disease. J Clin Invest. 2013 Jul;123(7):2786–8.
Murphy, Susan K. “Prenatal sensitization of a postnatal trigger for metabolic disease.” J Clin Invest, vol. 123, no. 7, July 2013, pp. 2786–88. Pubmed, doi:10.1172/JCI69399.
Murphy SK. Prenatal sensitization of a postnatal trigger for metabolic disease. J Clin Invest. 2013 Jul;123(7):2786–2788.
Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
July 2013
Volume
123
Issue
7
Start / End Page
2786 / 2788
Location
United States
Related Subject Headings
- Prenatal Exposure Delayed Effects
- Pregnancy Complications
- Pregnancy
- Obesity
- Male
- Immunology
- Humans
- Female
- Fatty Liver
- Cholestasis, Intrahepatic