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Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians.

Publication ,  Journal Article
Li, X; Wong, WL; Cheung, CY-L; Cheng, C-Y; Ikram, MK; Li, J; Chia, KS; Wong, TY
Published in: Invest Ophthalmol Vis Sci
May 1, 2013

PURPOSE: To investigate potential racial/ethnic differences in retinal vascular geometric parameters in a multiethnic Asian population (Chinese, Malay, and Indian) free of clinical diseases. METHODS: A series of retinal vascular parameters were measured from retinal photographs using a computer-assisted program following a standardized protocol. Healthy participants were defined as nonsmokers, the absence of diabetes mellitus, uncontrolled hypertension, obesity, stroke, heart disease, glaucoma, and retinopathy. RESULTS: THERE WERE SIGNIFICANT DIFFERENCES IN MEASUREMENTS OF RETINAL VASCULAR CALIBER, TORTUOSITY, AND FRACTAL DIMENSION AMONG THE THREE ETHNIC GROUPS. IN MULTIPLE LINEAR REGRESSION MODEL CONTROLLING FOR AGE, SEX, BODY MASS INDEX, SYSTOLIC BLOOD PRESSURE, CHOLESTEROL, AND GLUCOSE LEVELS, INDIANS HAD THE LARGEST ARTERIOLAR AND VENULAR CALIBERS (ARTERIOLES [SE]: 158.94 μm [1.00]; venules: 228.26 μm [1.53]), followed by Malays (arterioles: 138.31 μm [0.74]; venules: 204.26 μm [1.13]), and then Chinese (arterioles: 131.20 μm [0.84]; venules: 195.09 μm [1.28]). Chinese had the largest arteriolar and venular tortuosity (arterioles [× $${10}^{5}$$]: 7.20 [0.08] VENULES [ $${10}^{5}$$]: 9.09 [0.10]), and venular fractal dimension (1.244 [0.003]). There were no statistically significant differences in other retinal vascular parameters after correcting multiple comparisons by the method of modified false discovery rate. CONCLUSIONS: We found that among ethnic groups composed of healthy Chinese, Malay, and Indians, there were statistically significant differences in several retinal parameters. There exist racial influences in retinal vascular parameters and other yet unknown or unmeasured environmental factor or lifestyle habits and genetic variations not related to race that may also contribute to these differences.

Duke Scholars

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

May 1, 2013

Volume

54

Issue

5

Start / End Page

3650 / 3656

Location

United States

Related Subject Headings

  • White People
  • Socioeconomic Factors
  • Retinal Vessels
  • Retina
  • Reference Values
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Indonesia
  • India
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, X., Wong, W. L., Cheung, C.-L., Cheng, C.-Y., Ikram, M. K., Li, J., … Wong, T. Y. (2013). Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians. Invest Ophthalmol Vis Sci, 54(5), 3650–3656. https://doi.org/10.1167/iovs.12-11126
Li, Xiang, Wan Ling Wong, Carol Yim-Lui Cheung, Ching-Yu Cheng, Mohammad Kamran Ikram, Jialiang Li, Kee Seng Chia, and Tien Yin Wong. “Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians.Invest Ophthalmol Vis Sci 54, no. 5 (May 1, 2013): 3650–56. https://doi.org/10.1167/iovs.12-11126.
Li X, Wong WL, Cheung CY-L, Cheng C-Y, Ikram MK, Li J, et al. Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians. Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3650–6.
Li, Xiang, et al. “Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians.Invest Ophthalmol Vis Sci, vol. 54, no. 5, May 2013, pp. 3650–56. Pubmed, doi:10.1167/iovs.12-11126.
Li X, Wong WL, Cheung CY-L, Cheng C-Y, Ikram MK, Li J, Chia KS, Wong TY. Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians. Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3650–3656.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

May 1, 2013

Volume

54

Issue

5

Start / End Page

3650 / 3656

Location

United States

Related Subject Headings

  • White People
  • Socioeconomic Factors
  • Retinal Vessels
  • Retina
  • Reference Values
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Indonesia
  • India