Skip to main content

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Publication ,  Journal Article
Peragallo Urrutia, R; Coeytaux, RR; McBroom, AJ; Gierisch, JM; Havrilesky, LJ; Moorman, PG; Lowery, WJ; Dinan, M; Hasselblad, V; Sanders, GD ...
Published in: Obstet Gynecol
August 2013

OBJECTIVE: To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. DATA SOURCES: We searched PubMed, Embase, the Cochrane Database of Systematic Reviews, and ClinicalTrials.gov for studies published from January 1995 through June 2012 that evaluated the association between OCP use and risk of venous thromboembolism, stroke, or MI. METHODS OF STUDY SELECTION: We reviewed 6,476 citations. We included English-language, controlled studies with human participants reporting a quantitative association between exposure to OCPs and outcomes of venous thromboembolism, stroke, or MI. Two investigators independently reviewed articles for inclusion or exclusion; discordant decisions were resolved by team review and consensus. Random-effects meta-analysis was used to generate summary odds ratios (ORs). TABULATION, INTEGRATION, AND RESULTS: Fifty studies met inclusion criteria. There were no randomized clinical trials. We found threefold increased odds of venous thromboembolism among current compared with noncurrent OCP users (14 studies; OR 2.97, 95% confidence interval [CI] 2.46-3.59). We found twofold increased odds of ischemic stroke (seven studies; OR 1.90, 95% CI 1.24-2.91). There was no evidence of increased risk of hemorrhagic stroke (four studies; OR 1.03, 95% CI 0.71-1.49) or MI (eight studies; OR 1.34, 95% CI 0.87-2.08). CONCLUSION: Current use of combined OCPs is associated with increased odds of venous thromboembolism and ischemic stroke but not hemorrhagic stroke or MI.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

August 2013

Volume

122

Issue

2 Pt 1

Start / End Page

380 / 389

Location

United States

Related Subject Headings

  • Venous Thromboembolism
  • Stroke
  • Risk Assessment
  • Obstetrics & Reproductive Medicine
  • Myocardial Infarction
  • Humans
  • Female
  • Contraceptives, Oral, Hormonal
  • 3215 Reproductive medicine
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Peragallo Urrutia, R., Coeytaux, R. R., McBroom, A. J., Gierisch, J. M., Havrilesky, L. J., Moorman, P. G., … Myers, E. R. (2013). Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis. Obstet Gynecol, 122(2 Pt 1), 380–389. https://doi.org/10.1097/AOG.0b013e3182994c43
Peragallo Urrutia, Rachel, Remy R. Coeytaux, Amanda J. McBroom, Jennifer M. Gierisch, Laura J. Havrilesky, Patricia G. Moorman, William J. Lowery, et al. “Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.Obstet Gynecol 122, no. 2 Pt 1 (August 2013): 380–89. https://doi.org/10.1097/AOG.0b013e3182994c43.
Peragallo Urrutia R, Coeytaux RR, McBroom AJ, Gierisch JM, Havrilesky LJ, Moorman PG, et al. Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis. Obstet Gynecol. 2013 Aug;122(2 Pt 1):380–9.
Peragallo Urrutia, Rachel, et al. “Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.Obstet Gynecol, vol. 122, no. 2 Pt 1, Aug. 2013, pp. 380–89. Pubmed, doi:10.1097/AOG.0b013e3182994c43.
Peragallo Urrutia R, Coeytaux RR, McBroom AJ, Gierisch JM, Havrilesky LJ, Moorman PG, Lowery WJ, Dinan M, Hasselblad V, Sanders GD, Myers ER. Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis. Obstet Gynecol. 2013 Aug;122(2 Pt 1):380–389.

Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

August 2013

Volume

122

Issue

2 Pt 1

Start / End Page

380 / 389

Location

United States

Related Subject Headings

  • Venous Thromboembolism
  • Stroke
  • Risk Assessment
  • Obstetrics & Reproductive Medicine
  • Myocardial Infarction
  • Humans
  • Female
  • Contraceptives, Oral, Hormonal
  • 3215 Reproductive medicine
  • 1114 Paediatrics and Reproductive Medicine