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F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia.

Publication ,  Journal Article
Hockenberry, MJ; Taylor, OA; Gundy, PM; Ross, AK; Pasvogel, A; Montgomery, D; Ribbeck, P; McCarthy, K; Moore, I
Published in: Biological research for nursing
July 2014

Acute lymphoblastic leukemia (ALL) is the most prevalent and curable cancer among children and adolescents less than 15 years of age in the United States. Essential for cure of childhood ALL is prophylactic treatment of the central nervous system (CNS), with methotrexate (MTX) being the most widely used drug in this treatment. While CNS treatment has contributed to long-term disease-free survival, resulting declines in academic abilities have been reported. There is growing evidence that CNS treatment with MTX increases oxidative stress, a potential mechanism of CNS injury. This article reports changes in oxidative stress, measured by the biomarker F2-isoprostane (F2-IsoP), in the cerebrospinal fluid (CSF) in 47 children with ALL during the first 18 months of treatment. The number of CSF samples ranged from 5 to 14 during postinduction and from 1 to 9 during continuation. Total doses of intrathecal MTX during postinduction were significantly correlated with the mean and highest concentrations of F2-IsoP during postinduction and the mean concentration of F2-IsoP during continuation. F2-IsoP concentrations during postinduction and continuation were higher in children who received more than six doses of intrathecal MTX. New therapies for a highly curable disease such as childhood leukemia have the potential to be individualized in the future, requiring reliable molecular and biochemical markers, such as oxidative stress indicators. Innovative use of biomarkers has the potential to increase our understanding of treatment-related toxicities and associated symptoms and to inform future therapeutic approaches for optimizing cure and quality of life among children with leukemia.

Duke Scholars

Published In

Biological research for nursing

DOI

EISSN

1552-4175

ISSN

1099-8004

Publication Date

July 2014

Volume

16

Issue

3

Start / End Page

303 / 309

Related Subject Headings

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oxidative Stress
  • Nursing
  • Methotrexate
  • Male
  • Humans
  • Female
  • F2-Isoprostanes
  • Dose-Response Relationship, Drug
  • Child, Preschool
 

Citation

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Hockenberry, M. J., Taylor, O. A., Gundy, P. M., Ross, A. K., Pasvogel, A., Montgomery, D., … Moore, I. (2014). F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia. Biological Research for Nursing, 16(3), 303–309. https://doi.org/10.1177/1099800413498507
Hockenberry, Marilyn J., Olga A. Taylor, Patricia M. Gundy, Adam K. Ross, Alice Pasvogel, David Montgomery, Phillip Ribbeck, Kathy McCarthy, and Ida Moore. “F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia.Biological Research for Nursing 16, no. 3 (July 2014): 303–9. https://doi.org/10.1177/1099800413498507.
Hockenberry MJ, Taylor OA, Gundy PM, Ross AK, Pasvogel A, Montgomery D, et al. F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia. Biological research for nursing. 2014 Jul;16(3):303–9.
Hockenberry, Marilyn J., et al. “F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia.Biological Research for Nursing, vol. 16, no. 3, July 2014, pp. 303–09. Epmc, doi:10.1177/1099800413498507.
Hockenberry MJ, Taylor OA, Gundy PM, Ross AK, Pasvogel A, Montgomery D, Ribbeck P, McCarthy K, Moore I. F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia. Biological research for nursing. 2014 Jul;16(3):303–309.
Journal cover image

Published In

Biological research for nursing

DOI

EISSN

1552-4175

ISSN

1099-8004

Publication Date

July 2014

Volume

16

Issue

3

Start / End Page

303 / 309

Related Subject Headings

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oxidative Stress
  • Nursing
  • Methotrexate
  • Male
  • Humans
  • Female
  • F2-Isoprostanes
  • Dose-Response Relationship, Drug
  • Child, Preschool