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Pharmacological resolution of a multiloculated Candida spp. liver abscess in a preterm neonate.

Publication ,  Journal Article
Picone, S; Manzoni, P; Bedetta, M; Mostert, M; Benjamin, DK; Paolillo, P
Published in: Early Hum Dev
June 2013

We report the case of a 31-week gestational age neonate with Candida albicans sepsis and a hepatic abscess. Diagnosis relied on clinical and radiological signs of sepsis, liver function impairment and culture isolation of Candida spp. from sterile sites. Liver ultrasound documented the presence of a multiloculated abscess. Treatment with micafungin (3 mg/kg/day) resulted in normalization of liver function and inflammatory laboratory values and improvement of clinical condition. After 30 days of treatment, the liver abscess resolved and at the 8-month follow up the infant is doing well. Prompt diagnosis and antifungal treatment avoided surgical drainage and liver surgery in this high-risk neonate.

Duke Scholars

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

June 2013

Volume

89 Suppl 1

Start / End Page

S47 / S50

Location

Ireland

Related Subject Headings

  • Ultrasonography
  • Treatment Outcome
  • Pediatrics
  • Micafungin
  • Male
  • Liver Abscess
  • Liver
  • Lipopeptides
  • Infant, Premature, Diseases
  • Infant, Premature
 

Citation

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Picone, S., Manzoni, P., Bedetta, M., Mostert, M., Benjamin, D. K., & Paolillo, P. (2013). Pharmacological resolution of a multiloculated Candida spp. liver abscess in a preterm neonate. Early Hum Dev, 89 Suppl 1, S47–S50. https://doi.org/10.1016/S0378-3782(13)70015-X
Picone, Simonetta, Paolo Manzoni, Manuela Bedetta, Michael Mostert, Daniel K. Benjamin, and Piermichele Paolillo. “Pharmacological resolution of a multiloculated Candida spp. liver abscess in a preterm neonate.Early Hum Dev 89 Suppl 1 (June 2013): S47–50. https://doi.org/10.1016/S0378-3782(13)70015-X.
Picone S, Manzoni P, Bedetta M, Mostert M, Benjamin DK, Paolillo P. Pharmacological resolution of a multiloculated Candida spp. liver abscess in a preterm neonate. Early Hum Dev. 2013 Jun;89 Suppl 1:S47–50.
Picone, Simonetta, et al. “Pharmacological resolution of a multiloculated Candida spp. liver abscess in a preterm neonate.Early Hum Dev, vol. 89 Suppl 1, June 2013, pp. S47–50. Pubmed, doi:10.1016/S0378-3782(13)70015-X.
Picone S, Manzoni P, Bedetta M, Mostert M, Benjamin DK, Paolillo P. Pharmacological resolution of a multiloculated Candida spp. liver abscess in a preterm neonate. Early Hum Dev. 2013 Jun;89 Suppl 1:S47–S50.
Journal cover image

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

June 2013

Volume

89 Suppl 1

Start / End Page

S47 / S50

Location

Ireland

Related Subject Headings

  • Ultrasonography
  • Treatment Outcome
  • Pediatrics
  • Micafungin
  • Male
  • Liver Abscess
  • Liver
  • Lipopeptides
  • Infant, Premature, Diseases
  • Infant, Premature