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Therapeutic implications of biomarkers in chronic heart failure.

Publication ,  Journal Article
Ahmad, T; O'Connor, CM
Published in: Clin Pharmacol Ther
October 2013

Understanding of chronic heart failure (HF) has progressed from the concept of a purely hemodynamic disorder to that of a syndrome that results from dysfunction in interconnected molecular pathways. As a result, the focus of research investigations and clinical care has shifted to measurement and modification of maladaptive molecular processes. Accumulating evidence shows that molecular biomarkers provide a window into the pathophysiology of chronic HF and therefore have important therapeutic implications. However, the use of biomarkers in the treatment of HF remains in its infancy. This is partly a result of shortcomings in research studies and a dearth of biomarker-guided clinical trials. In this review, we summarize the potential therapeutic implications of promising biomarkers that uniquely capture the molecular dysfunction that occurs in chronic HF. We discuss the need for strict statistical standards in biomarker studies, provide an overview of biomarker-guided clinical trial design, and discuss the therapeutic potential of a multimarker-based strategy.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

October 2013

Volume

94

Issue

4

Start / End Page

468 / 479

Location

United States

Related Subject Headings

  • Pharmacology & Pharmacy
  • Natriuretic Peptides
  • Models, Cardiovascular
  • Humans
  • Heart Failure
  • Clinical Trials as Topic
  • Chronic Disease
  • Biomarkers, Pharmacological
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Ahmad, T., & O’Connor, C. M. (2013). Therapeutic implications of biomarkers in chronic heart failure. Clin Pharmacol Ther, 94(4), 468–479. https://doi.org/10.1038/clpt.2013.139
Ahmad, T., and C. M. O’Connor. “Therapeutic implications of biomarkers in chronic heart failure.Clin Pharmacol Ther 94, no. 4 (October 2013): 468–79. https://doi.org/10.1038/clpt.2013.139.
Ahmad T, O’Connor CM. Therapeutic implications of biomarkers in chronic heart failure. Clin Pharmacol Ther. 2013 Oct;94(4):468–79.
Ahmad, T., and C. M. O’Connor. “Therapeutic implications of biomarkers in chronic heart failure.Clin Pharmacol Ther, vol. 94, no. 4, Oct. 2013, pp. 468–79. Pubmed, doi:10.1038/clpt.2013.139.
Ahmad T, O’Connor CM. Therapeutic implications of biomarkers in chronic heart failure. Clin Pharmacol Ther. 2013 Oct;94(4):468–479.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

October 2013

Volume

94

Issue

4

Start / End Page

468 / 479

Location

United States

Related Subject Headings

  • Pharmacology & Pharmacy
  • Natriuretic Peptides
  • Models, Cardiovascular
  • Humans
  • Heart Failure
  • Clinical Trials as Topic
  • Chronic Disease
  • Biomarkers, Pharmacological
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences