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Comparison of parameter estimations using dual-input and arterial-input in liver kinetic studies of FDG metabolism

Publication ,  Journal Article
Yunfeng, C; Jing, B
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
December 1, 2005

Liver kinetic study of [18F]2-fluoro-2-deoxy-D-glucose (FDG) metabolism in human body is an important tool for functional modeling and glucose metabolic rate estimation. In general, the arterial blood time-activity curve (TAC) and the tissue TAC are required as the input and output functions for the kinetic model. For liver study, however, the arterial-input may be not consistent with the actual model input because the liver has a dual blood supply from the hepatic artery (HA) and the portal vein (PV) to the liver. In this study, the result of model parameter estimation using dual-input function is compared with that using arterial-input function. First, a dynamic positron emission tomography (PET) experiment is performed after injection of FDG into the human body. The TACs of aortic blood, PV blood, and five regions of interest (ROIs) in liver are obtained from the PET image. Then, the dual-input curve is generated by calculating weighted sum of both the arterial and PV input curves. Finally, the five liver ROIs' kinetic parameters are estimated with arterial-input and dual-input functions respectively. The results indicate that the two methods provide different parameter estimations and the dual-input function may lead to more accurate parameter estimation. © 2005 IEEE.

Duke Scholars

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ISSN

0589-1019

Publication Date

December 1, 2005

Volume

7 VOLS

Start / End Page

2345 / 2348
 

Citation

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Yunfeng, C., & Jing, B. (2005). Comparison of parameter estimations using dual-input and arterial-input in liver kinetic studies of FDG metabolism. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 7 VOLS, 2345–2348.
Yunfeng, C., and B. Jing. “Comparison of parameter estimations using dual-input and arterial-input in liver kinetic studies of FDG metabolism.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 7 VOLS (December 1, 2005): 2345–48.
Yunfeng C, Jing B. Comparison of parameter estimations using dual-input and arterial-input in liver kinetic studies of FDG metabolism. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2005 Dec 1;7 VOLS:2345–8.
Yunfeng, C., and B. Jing. “Comparison of parameter estimations using dual-input and arterial-input in liver kinetic studies of FDG metabolism.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 7 VOLS, Dec. 2005, pp. 2345–48.
Yunfeng C, Jing B. Comparison of parameter estimations using dual-input and arterial-input in liver kinetic studies of FDG metabolism. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2005 Dec 1;7 VOLS:2345–2348.

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ISSN

0589-1019

Publication Date

December 1, 2005

Volume

7 VOLS

Start / End Page

2345 / 2348