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A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery.

Publication ,  Journal Article
Huraux, C; Makita, T; Montes, F; Szlam, F; Levy, JH
Published in: Anesthesiology
June 1998

BACKGROUND: Vasospasm of arterial grafts represents an unpredictable complication of coronary artery surgery and may compromise myocardial revascularization, and treatment is based on empirical therapy with nitroglycerin. Because of the potential for tolerance to nitroglycerin to occur, the authors studied different vasodilators acting through separate pathways on segments of human internal mammary artery. METHODS: Isolated vascular rings were precontracted with norepinephrine (1 microM), KCl, or the thromboxane A2 analogue (U46619, 10 nm). Nitroglycerin (a nitrovasodilator), milrinone (a type III phosphodiesterase inhibitor), papaverine (a phosphodiesterase inhibitor), prostaglandin E1, and isradipine (a dihydropyridine calcium channel blocker) were added in a cumulative fashion. RESULTS: The analysis of the concentration-response curves showed that vasodilators induced 90-100% relaxation of the constricted segments with norepinephrine or the thromboxane A2 analogue, except prostaglandin E1, which produced 73% relaxation at maximal concentrations. The effective concentrations of vasodilator agent that caused 50% relaxation for nitroglycerin and milrinone were within the range of the reported therapeutic concentrations in plasma. Isradipine was also effective at reversing receptor-mediated contraction (maximal relaxation=100% in internal mammary artery contracted with norepinephrine; maximal relaxation=0% in internal mammary artery contracted with the thromboxane A2 analogue). CONCLUSIONS: Vasodilator drugs acting through multiple pathways are effective at reversing in vitro vasoconstriction.

Duke Scholars

Published In

Anesthesiology

DOI

ISSN

0003-3022

Publication Date

June 1998

Volume

88

Issue

6

Start / End Page

1654 / 1659

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Thromboxane A2
  • Muscle Relaxation
  • Mammary Arteries
  • In Vitro Techniques
  • Humans
  • Dose-Response Relationship, Drug
  • Anesthesiology
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Huraux, C., Makita, T., Montes, F., Szlam, F., & Levy, J. H. (1998). A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery. Anesthesiology, 88(6), 1654–1659. https://doi.org/10.1097/00000542-199806000-00030
Huraux, C., T. Makita, F. Montes, F. Szlam, and J. H. Levy. “A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery.Anesthesiology 88, no. 6 (June 1998): 1654–59. https://doi.org/10.1097/00000542-199806000-00030.
Huraux C, Makita T, Montes F, Szlam F, Levy JH. A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery. Anesthesiology. 1998 Jun;88(6):1654–9.
Huraux, C., et al. “A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery.Anesthesiology, vol. 88, no. 6, June 1998, pp. 1654–59. Pubmed, doi:10.1097/00000542-199806000-00030.
Huraux C, Makita T, Montes F, Szlam F, Levy JH. A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery. Anesthesiology. 1998 Jun;88(6):1654–1659.

Published In

Anesthesiology

DOI

ISSN

0003-3022

Publication Date

June 1998

Volume

88

Issue

6

Start / End Page

1654 / 1659

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Thromboxane A2
  • Muscle Relaxation
  • Mammary Arteries
  • In Vitro Techniques
  • Humans
  • Dose-Response Relationship, Drug
  • Anesthesiology
  • 1103 Clinical Sciences