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Functional maturity of the coagulation system in children: an evaluation using thrombelastography.

Publication ,  Journal Article
Miller, BE; Bailey, JM; Mancuso, TJ; Weinstein, MS; Holbrook, GW; Silvey, EM; Tosone, SR; Levy, JH
Published in: Anesth Analg
April 1997

There are quantitative deficiencies in the coagulation system for at least the first 6 mo of life. Clinical experience, however, does not indicate an increased risk of excessive bleeding during surgical procedures. Thrombelastography, a test providing a functional evaluation of coagulation, was used to assess the hemostatic system of pediatric patients under 2 yr of age. Thrombelastographic data were obtained from 237 healthy pediatric patients less than 2 yr of age undergoing elective noncardiac surgery. Five groups were distinguished: under 30 days, 1-3 mo, 3-6 mo, 6-12 mo, and 12-24 mo. Thrombelastography revealed no defects in coagulation when these groups were compared to each other or to adults, indicating a functionally intact hemostatic process even in neonates. Indeed, children less than 12 mo of age were found to initiate and develop clot faster than adults, with the coagulation process slowing to adult rates after 1 yr of age. In addition to defining functional integrity, our data represents a set of pediatric control thrombelastographic values that have not been previously reported and that may become important in understanding coagulation changes that accompany disease states and surgery in pediatric patients.

Duke Scholars

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

April 1997

Volume

84

Issue

4

Start / End Page

745 / 748

Location

United States

Related Subject Headings

  • Thrombelastography
  • Infant, Newborn
  • Infant
  • Humans
  • Child, Preschool
  • Blood Coagulation
  • Anesthesiology
  • Age Factors
  • 3202 Clinical sciences
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
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Miller, B. E., Bailey, J. M., Mancuso, T. J., Weinstein, M. S., Holbrook, G. W., Silvey, E. M., … Levy, J. H. (1997). Functional maturity of the coagulation system in children: an evaluation using thrombelastography. Anesth Analg, 84(4), 745–748. https://doi.org/10.1097/00000539-199704000-00008
Miller, B. E., J. M. Bailey, T. J. Mancuso, M. S. Weinstein, G. W. Holbrook, E. M. Silvey, S. R. Tosone, and J. H. Levy. “Functional maturity of the coagulation system in children: an evaluation using thrombelastography.Anesth Analg 84, no. 4 (April 1997): 745–48. https://doi.org/10.1097/00000539-199704000-00008.
Miller BE, Bailey JM, Mancuso TJ, Weinstein MS, Holbrook GW, Silvey EM, et al. Functional maturity of the coagulation system in children: an evaluation using thrombelastography. Anesth Analg. 1997 Apr;84(4):745–8.
Miller, B. E., et al. “Functional maturity of the coagulation system in children: an evaluation using thrombelastography.Anesth Analg, vol. 84, no. 4, Apr. 1997, pp. 745–48. Pubmed, doi:10.1097/00000539-199704000-00008.
Miller BE, Bailey JM, Mancuso TJ, Weinstein MS, Holbrook GW, Silvey EM, Tosone SR, Levy JH. Functional maturity of the coagulation system in children: an evaluation using thrombelastography. Anesth Analg. 1997 Apr;84(4):745–748.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

April 1997

Volume

84

Issue

4

Start / End Page

745 / 748

Location

United States

Related Subject Headings

  • Thrombelastography
  • Infant, Newborn
  • Infant
  • Humans
  • Child, Preschool
  • Blood Coagulation
  • Anesthesiology
  • Age Factors
  • 3202 Clinical sciences
  • 1109 Neurosciences