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Determination of the hemodynamics and histamine release of rocuronium (Org 9426) when administered in increased doses under N2O/O2-sufentanil anesthesia.

Publication ,  Journal Article
Levy, JH; Davis, GK; Duggan, J; Szlam, F
Published in: Anesth Analg
February 1994

The cardiovascular effects, histamine release potential, and pharmacodynamics of rocuronium were determined in adult patients randomized to receive rapid (5 s) intravenous (i.v.) bolus doses of 600, 900, or 1200 micrograms/kg (2.0, 3.0, and 4.0 times the ED95) with maintenance doses of 150 micrograms/kg. There were no statistically significant hemodynamic effects (heart rate, blood pressure, mean arterial pressure [MAP] or electrocardiogram [ECG]) after administration of rocuronium. There were no increases in plasma histamine levels at 1, 3, and 5 min after the rapid i.v. bolus of rocuronium as determined by a new radioimmunoassay (RIA) with a sensitivity for histamine quantification of 0.05 ng/mL. Endotracheal intubation was successfully performed 6 min after rocuronium administration (and after plasma samples were obtained). The mean +/- SD clinical durations of 600-, 900-, and 1200-micrograms/kg intubating doses of rocuronium under N2O/O2-sufentanil anesthesia were 45 +/- 20 min, 66 +/- 16 min, and 85 +/- 22 min, respectively. We conclude that rocuronium can be administered safely over a wide range of doses (2-4 x ED95), with minimum hemodynamic effects or histamine release.

Duke Scholars

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

February 1994

Volume

78

Issue

2

Start / End Page

318 / 321

Location

United States

Related Subject Headings

  • Sufentanil
  • Sensitivity and Specificity
  • Rocuronium
  • Oxygen
  • Nitrous Oxide
  • Neuromuscular Nondepolarizing Agents
  • Middle Aged
  • Intubation, Intratracheal
  • Injections, Intravenous
  • Humans
 

Citation

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Levy, J. H., Davis, G. K., Duggan, J., & Szlam, F. (1994). Determination of the hemodynamics and histamine release of rocuronium (Org 9426) when administered in increased doses under N2O/O2-sufentanil anesthesia. Anesth Analg, 78(2), 318–321. https://doi.org/10.1213/00000539-199402000-00020
Levy, J. H., G. K. Davis, J. Duggan, and F. Szlam. “Determination of the hemodynamics and histamine release of rocuronium (Org 9426) when administered in increased doses under N2O/O2-sufentanil anesthesia.Anesth Analg 78, no. 2 (February 1994): 318–21. https://doi.org/10.1213/00000539-199402000-00020.
Levy, J. H., et al. “Determination of the hemodynamics and histamine release of rocuronium (Org 9426) when administered in increased doses under N2O/O2-sufentanil anesthesia.Anesth Analg, vol. 78, no. 2, Feb. 1994, pp. 318–21. Pubmed, doi:10.1213/00000539-199402000-00020.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

February 1994

Volume

78

Issue

2

Start / End Page

318 / 321

Location

United States

Related Subject Headings

  • Sufentanil
  • Sensitivity and Specificity
  • Rocuronium
  • Oxygen
  • Nitrous Oxide
  • Neuromuscular Nondepolarizing Agents
  • Middle Aged
  • Intubation, Intratracheal
  • Injections, Intravenous
  • Humans