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Amrinone: pharmacokinetics and pharmacodynamics.

Publication ,  Other
Levy, JH; Bailey, JM
Published in: J Cardiothorac Anesth
December 1989

Amrinone is a selective inhibitor of phosphodiesterase fraction 3 in both cardiac and smooth muscle. Intravenous administration in humans produces increased contractility and vasodilation of venous capacitance and arterial conductance vessels. The elimination half-life in healthy patients is reported to be 2.6 to 4.1 hours, making it the only long-acting positive inotropic agent available that can be administered either as an intravenous bolus or by infusion. A low incidence of side effects, often minor, has been reported with intravenous use. Thrombocytopenia does not seem to be a problem with short-term use. Amrinone represents a new approach in the pharmacologic therapy for ventricular dysfunction following cardiac surgery.

Duke Scholars

Published In

J Cardiothorac Anesth

DOI

ISSN

0888-6296

Publication Date

December 1989

Volume

3

Issue

6 Suppl 2

Start / End Page

10 / 14

Location

United States

Related Subject Headings

  • Humans
  • Drug Combinations
  • Anesthesiology
  • Amrinone
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Levy, J. H., & Bailey, J. M. (1989). Amrinone: pharmacokinetics and pharmacodynamics. J Cardiothorac Anesth. United States. https://doi.org/10.1016/0888-6296(89)90054-9
Levy, J. H., and J. M. Bailey. “Amrinone: pharmacokinetics and pharmacodynamics.J Cardiothorac Anesth, December 1989. https://doi.org/10.1016/0888-6296(89)90054-9.
Levy JH, Bailey JM. Amrinone: pharmacokinetics and pharmacodynamics. Vol. 3, J Cardiothorac Anesth. 1989. p. 10–4.
Levy, J. H., and J. M. Bailey. “Amrinone: pharmacokinetics and pharmacodynamics.J Cardiothorac Anesth, vol. 3, no. 6 Suppl 2, Dec. 1989, pp. 10–14. Pubmed, doi:10.1016/0888-6296(89)90054-9.
Levy JH, Bailey JM. Amrinone: pharmacokinetics and pharmacodynamics. J Cardiothorac Anesth. 1989. p. 10–14.

Published In

J Cardiothorac Anesth

DOI

ISSN

0888-6296

Publication Date

December 1989

Volume

3

Issue

6 Suppl 2

Start / End Page

10 / 14

Location

United States

Related Subject Headings

  • Humans
  • Drug Combinations
  • Anesthesiology
  • Amrinone
  • 1102 Cardiorespiratory Medicine and Haematology