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Effects of protamine on histamine release from human lung.

Publication ,  Journal Article
Levy, JH; Faraj, BA; Zaidan, JR; Camp, VM
Published in: Agents Actions
August 1989

Animal mast cell models demonstrate direct histamine release by protamine. Investigators have proposed that protamine also releases histamine in man. We studied the effects of protamine alone and heparin-protamine mixtures on minced lung tissue for evidence of histamine release. We were unable to demonstrate the release of histamine despite positive anti-IgE controls. Nonimmunologic histamine release from human lung appears unlikely as a mechanism for protamine reactions in man.

Duke Scholars

Published In

Agents Actions

DOI

ISSN

0065-4299

Publication Date

August 1989

Volume

28

Issue

1-2

Start / End Page

70 / 72

Location

Switzerland

Related Subject Headings

  • Protamines
  • Lung
  • Immunoglobulin E
  • Humans
  • Histamine Release
  • Heparin
  • Antibodies, Anti-Idiotypic
 

Citation

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Levy, J. H., Faraj, B. A., Zaidan, J. R., & Camp, V. M. (1989). Effects of protamine on histamine release from human lung. Agents Actions, 28(1–2), 70–72. https://doi.org/10.1007/BF02022982
Levy, J. H., B. A. Faraj, J. R. Zaidan, and V. M. Camp. “Effects of protamine on histamine release from human lung.Agents Actions 28, no. 1–2 (August 1989): 70–72. https://doi.org/10.1007/BF02022982.
Levy JH, Faraj BA, Zaidan JR, Camp VM. Effects of protamine on histamine release from human lung. Agents Actions. 1989 Aug;28(1–2):70–2.
Levy, J. H., et al. “Effects of protamine on histamine release from human lung.Agents Actions, vol. 28, no. 1–2, Aug. 1989, pp. 70–72. Pubmed, doi:10.1007/BF02022982.
Levy JH, Faraj BA, Zaidan JR, Camp VM. Effects of protamine on histamine release from human lung. Agents Actions. 1989 Aug;28(1–2):70–72.

Published In

Agents Actions

DOI

ISSN

0065-4299

Publication Date

August 1989

Volume

28

Issue

1-2

Start / End Page

70 / 72

Location

Switzerland

Related Subject Headings

  • Protamines
  • Lung
  • Immunoglobulin E
  • Humans
  • Histamine Release
  • Heparin
  • Antibodies, Anti-Idiotypic