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A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.

Publication ,  Journal Article
Nicholas, MW; Dooley, MA; Hogan, SL; Anolik, J; Looney, J; Sanz, I; Clarke, SH
Published in: Clin Immunol
February 2008

We previously reported that some systemic lupus erythematosus (SLE) patients have a population of circulating memory B cells with >2-fold higher levels of CD19. We show here that the presence of CD19(hi) B cells correlates with long-term adverse outcomes. These B cells do not appear anergic, as they exhibit high basal levels of phosphorylated Syk and ERK1/2, signal transduce in response to BCR crosslinking, and can become plasma cells (PCs) in vitro. Autoreactive anti-Smith (Sm) B cells are enriched in this population and the degree of enrichment correlates with the log of the serum anti-Sm titer, arguing that they undergo clonal expansion before PC differentiation. PC differentiation may occur at sites of inflammation, as CD19(hi) B cells have elevated CXCR3 levels and chemotax in response to its ligand CXCL9. Thus, CD19(hi) B cells are precursors to anti-self PCs, and identify an SLE patient subset likely to experience poor clinical outcomes.

Duke Scholars

Published In

Clin Immunol

DOI

ISSN

1521-6616

Publication Date

February 2008

Volume

126

Issue

2

Start / End Page

189 / 201

Location

United States

Related Subject Headings

  • snRNP Core Proteins
  • Rituximab
  • Ribonucleoproteins, Small Nuclear
  • Receptors, CXCR3
  • Plasma Cells
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Immunology
  • Immunologic Memory
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nicholas, M. W., Dooley, M. A., Hogan, S. L., Anolik, J., Looney, J., Sanz, I., & Clarke, S. H. (2008). A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. Clin Immunol, 126(2), 189–201. https://doi.org/10.1016/j.clim.2007.10.004
Nicholas, Matilda W., Mary Anne Dooley, Susan L. Hogan, Jennifer Anolik, John Looney, Ingnacio Sanz, and Stephen H. Clarke. “A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.Clin Immunol 126, no. 2 (February 2008): 189–201. https://doi.org/10.1016/j.clim.2007.10.004.
Nicholas MW, Dooley MA, Hogan SL, Anolik J, Looney J, Sanz I, et al. A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. Clin Immunol. 2008 Feb;126(2):189–201.
Nicholas, Matilda W., et al. “A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.Clin Immunol, vol. 126, no. 2, Feb. 2008, pp. 189–201. Pubmed, doi:10.1016/j.clim.2007.10.004.
Nicholas MW, Dooley MA, Hogan SL, Anolik J, Looney J, Sanz I, Clarke SH. A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. Clin Immunol. 2008 Feb;126(2):189–201.
Journal cover image

Published In

Clin Immunol

DOI

ISSN

1521-6616

Publication Date

February 2008

Volume

126

Issue

2

Start / End Page

189 / 201

Location

United States

Related Subject Headings

  • snRNP Core Proteins
  • Rituximab
  • Ribonucleoproteins, Small Nuclear
  • Receptors, CXCR3
  • Plasma Cells
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Immunology
  • Immunologic Memory