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Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells.

Publication ,  Journal Article
Raposo, RAS; Abdel-Mohsen, M; Bilska, M; Montefiori, DC; Nixon, DF; Pillai, SK
Published in: J Virol
November 2013

Expression of cell-intrinsic antiviral factors suppresses HIV-1 replication. We hypothesized that cellular activation modulates host restriction and susceptibility to HIV-1 infection. We measured the gene expression of 34 antiviral factors in healthy peripheral blood mononuclear cells (PBMC). Cellular activation induced expression of interferon-stimulated gene 15 (ISG15), tripartite motif 5α (TRIM5α), bone marrow stromal cell antigen 2 (BST-2)/tetherin, and certain apolipoprotein B mRNA editing enzyme 3 (APOBEC3) family members. Expression of RTF1, RNA polymerase II-associated factor 1 (PAF1), TRIM11, TRIM26, and BST-2/tetherin correlated with decreased HIV-1 infectivity. This report demonstrates synchronous effects of activation-induced antiviral genes on HIV-1 infectivity, providing candidates for pharmacological manipulation.

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Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

November 2013

Volume

87

Issue

21

Start / End Page

11924 / 11929

Location

United States

Related Subject Headings

  • Virology
  • Leukocytes, Mononuclear
  • Immunity, Innate
  • Humans
  • HIV-1
  • Gene Expression Profiling
  • Cells, Cultured
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 30 Agricultural, veterinary and food sciences
 

Citation

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Raposo, R. A. S., Abdel-Mohsen, M., Bilska, M., Montefiori, D. C., Nixon, D. F., & Pillai, S. K. (2013). Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells. J Virol, 87(21), 11924–11929. https://doi.org/10.1128/JVI.02128-13
Raposo, Rui André Saraiva, Mohamed Abdel-Mohsen, Miroslawa Bilska, David C. Montefiori, Douglas F. Nixon, and Satish K. Pillai. “Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells.J Virol 87, no. 21 (November 2013): 11924–29. https://doi.org/10.1128/JVI.02128-13.
Raposo RAS, Abdel-Mohsen M, Bilska M, Montefiori DC, Nixon DF, Pillai SK. Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells. J Virol. 2013 Nov;87(21):11924–9.
Raposo, Rui André Saraiva, et al. “Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells.J Virol, vol. 87, no. 21, Nov. 2013, pp. 11924–29. Pubmed, doi:10.1128/JVI.02128-13.
Raposo RAS, Abdel-Mohsen M, Bilska M, Montefiori DC, Nixon DF, Pillai SK. Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells. J Virol. 2013 Nov;87(21):11924–11929.

Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

November 2013

Volume

87

Issue

21

Start / End Page

11924 / 11929

Location

United States

Related Subject Headings

  • Virology
  • Leukocytes, Mononuclear
  • Immunity, Innate
  • Humans
  • HIV-1
  • Gene Expression Profiling
  • Cells, Cultured
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 30 Agricultural, veterinary and food sciences