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A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network.

Publication ,  Journal Article
Nijhout, HF; Callier, V
Published in: Frontiers in physiology
January 2013

In this paper we develop a novel mathematical model of the insulin-TOR-MAPK signaling network that controls growth. Most data on the properties of the insulin and MAPK signaling networks are static and the responses to experimental interventions, such as knockouts, overexpression, and hormonal input are typically reported as scaled quantities. The modeling paradigm we develop here uses scaled variables and is ideally suited to simulate systems in which much of the available data are scaled. Our mathematical representation of signaling networks provides a way to reconcile theory and experiments, thus leading to a better understanding of the properties and function of these signaling networks. We test the performance of the model against a broad diversity of experimental data. The model correctly reproduces experimental insulin dose-response relationships. We study the interaction between insulin and MAPK signaling in the control of protein synthesis, and the interactions between amino acids, insulin and TOR signaling. We study the effects of variation in FOXO expression on protein synthesis and glucose transport capacity, and show that a FOXO knockout can partially rescue protein synthesis capacity of an insulin receptor (INR) knockout. We conclude that the modeling paradigm we develop provides a simple tool to investigate the qualitative properties of signaling networks.

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Published In

Frontiers in physiology

DOI

EISSN

1664-042X

ISSN

1664-042X

Publication Date

January 2013

Volume

4

Start / End Page

245

Related Subject Headings

  • 3208 Medical physiology
  • 3101 Biochemistry and cell biology
  • 1701 Psychology
  • 1116 Medical Physiology
  • 0606 Physiology
 

Citation

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Nijhout, H. F., & Callier, V. (2013). A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network. Frontiers in Physiology, 4, 245. https://doi.org/10.3389/fphys.2013.00245
Nijhout, H Frederik, and Viviane Callier. “A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network.Frontiers in Physiology 4 (January 2013): 245. https://doi.org/10.3389/fphys.2013.00245.
Nijhout HF, Callier V. A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network. Frontiers in physiology. 2013 Jan;4:245.
Nijhout, H. Frederik, and Viviane Callier. “A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network.Frontiers in Physiology, vol. 4, Jan. 2013, p. 245. Epmc, doi:10.3389/fphys.2013.00245.
Nijhout HF, Callier V. A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network. Frontiers in physiology. 2013 Jan;4:245.

Published In

Frontiers in physiology

DOI

EISSN

1664-042X

ISSN

1664-042X

Publication Date

January 2013

Volume

4

Start / End Page

245

Related Subject Headings

  • 3208 Medical physiology
  • 3101 Biochemistry and cell biology
  • 1701 Psychology
  • 1116 Medical Physiology
  • 0606 Physiology