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Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.

Publication ,  Journal Article
Hazai, D; Szudoczki, R; Ding, J; Soderling, SH; Weinberg, RJ; Sótonyi, P; Rácz, B
Published in: PLoS One
2013

By conveying signals from the small GTPase family of proteins to the Arp2/3 complex, proteins of the WAVE family facilitate actin remodeling. The WAVE-1 isoform is expressed at high levels in brain, where it plays a role in normal synaptic processing, and is implicated in hippocampus-dependent memory retention. We used electron microscopy to determine whether synaptic structure is modified in the hippocampus of WAVE-1 knockout mice, focusing on the neuropil of CA1 stratum radiatum. Mice lacking WAVE-1 exhibited alterations in the morphology of both axon terminals and dendritic spines; the relationship between the synaptic partners was also modified. The abnormal synaptic morphology we observed suggests that signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

9

Start / End Page

e75248

Location

United States

Related Subject Headings

  • Wiskott-Aldrich Syndrome Protein Family
  • Synapses
  • Presynaptic Terminals
  • Microscopy, Electron
  • Mice, Knockout
  • Mice
  • Hippocampus
  • General Science & Technology
  • Dendritic Spines
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
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Hazai, D., Szudoczki, R., Ding, J., Soderling, S. H., Weinberg, R. J., Sótonyi, P., & Rácz, B. (2013). Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1. PLoS One, 8(9), e75248. https://doi.org/10.1371/journal.pone.0075248
Hazai, Diána, Róbert Szudoczki, Jindong Ding, Scott H. Soderling, Richard J. Weinberg, Péter Sótonyi, and Bence Rácz. “Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.PLoS One 8, no. 9 (2013): e75248. https://doi.org/10.1371/journal.pone.0075248.
Hazai D, Szudoczki R, Ding J, Soderling SH, Weinberg RJ, Sótonyi P, et al. Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1. PLoS One. 2013;8(9):e75248.
Hazai, Diána, et al. “Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.PLoS One, vol. 8, no. 9, 2013, p. e75248. Pubmed, doi:10.1371/journal.pone.0075248.
Hazai D, Szudoczki R, Ding J, Soderling SH, Weinberg RJ, Sótonyi P, Rácz B. Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1. PLoS One. 2013;8(9):e75248.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

9

Start / End Page

e75248

Location

United States

Related Subject Headings

  • Wiskott-Aldrich Syndrome Protein Family
  • Synapses
  • Presynaptic Terminals
  • Microscopy, Electron
  • Mice, Knockout
  • Mice
  • Hippocampus
  • General Science & Technology
  • Dendritic Spines
  • Animals