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Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.

Publication ,  Journal Article
Patel, MJ; Batch, BC; Svetkey, LP; Bain, JR; Turer, CB; Haynes, C; Muehlbauer, MJ; Stevens, RD; Newgard, CB; Shah, SH
Published in: OMICS
December 2013

In overweight/obese individuals, cardiometabolic risk factors differ by race and sex categories. Small-molecule metabolites and metabolic hormone levels might also differ across these categories and contribute to risk factor heterogeneity. To explore this possibility, we performed a cross-sectional analysis of fasting plasma levels of 69 small-molecule metabolites and 13 metabolic hormones in 500 overweight/obese adults who participated in the Weight Loss Maintenance trial. Principal-components analysis (PCA) was used for reduction of metabolite data. Race and sex-stratified comparisons of metabolite factors and metabolic hormones were performed. African Americans represented 37.4% of the study participants, and females 63.0%. Of thirteen metabolite factors identified, three differed by race and sex: levels of factor 3 (branched-chain amino acids and related metabolites, p<0.0001), factor 6 (long-chain acylcarnitines, p<0.01), and factor 2 (medium-chain dicarboxylated acylcarnitines, p<0.0001) were higher in males vs. females; factor 6 levels were higher in Caucasians vs. African Americans (p<0.0001). Significant differences were also observed in hormones regulating body weight homeostasis. Among overweight/obese adults, there are significant race and sex differences in small-molecule metabolites and metabolic hormones; these differences may contribute to risk factor heterogeneity across race and sex subgroups and should be considered in future investigations with circulating metabolites and metabolic hormones.

Duke Scholars

Published In

OMICS

DOI

EISSN

1557-8100

Publication Date

December 2013

Volume

17

Issue

12

Start / End Page

627 / 635

Location

United States

Related Subject Headings

  • White People
  • Sex Characteristics
  • Principal Component Analysis
  • Overweight
  • Obesity
  • Middle Aged
  • Metabolome
  • Male
  • Ketones
  • Humans
 

Citation

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Patel, M. J., Batch, B. C., Svetkey, L. P., Bain, J. R., Turer, C. B., Haynes, C., … Shah, S. H. (2013). Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. OMICS, 17(12), 627–635. https://doi.org/10.1089/omi.2013.0031
Patel, Mahesh J., Bryan C. Batch, Laura P. Svetkey, James R. Bain, Christy Boling Turer, Carol Haynes, Michael J. Muehlbauer, Robert D. Stevens, Christopher B. Newgard, and Svati H. Shah. “Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.OMICS 17, no. 12 (December 2013): 627–35. https://doi.org/10.1089/omi.2013.0031.
Patel MJ, Batch BC, Svetkey LP, Bain JR, Turer CB, Haynes C, et al. Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. OMICS. 2013 Dec;17(12):627–35.
Patel, Mahesh J., et al. “Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.OMICS, vol. 17, no. 12, Dec. 2013, pp. 627–35. Pubmed, doi:10.1089/omi.2013.0031.
Patel MJ, Batch BC, Svetkey LP, Bain JR, Turer CB, Haynes C, Muehlbauer MJ, Stevens RD, Newgard CB, Shah SH. Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. OMICS. 2013 Dec;17(12):627–635.
Journal cover image

Published In

OMICS

DOI

EISSN

1557-8100

Publication Date

December 2013

Volume

17

Issue

12

Start / End Page

627 / 635

Location

United States

Related Subject Headings

  • White People
  • Sex Characteristics
  • Principal Component Analysis
  • Overweight
  • Obesity
  • Middle Aged
  • Metabolome
  • Male
  • Ketones
  • Humans