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C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.

Publication ,  Journal Article
Costello, EJ; Copeland, WE; Shanahan, L; Worthman, CM; Angold, A
Published in: Drug Alcohol Depend
December 1, 2013

BACKGROUND: Dysregulated immune function and elevated inflammation markers are seen in adults with chronic diseases, including some psychiatric disorders, but evidence on inflammation in the case of drug abuse is conflicting. OBJECTIVE: To test the concurrent and predictive relations between C-reactive protein (CRP) and use and abuse of alcohol, nicotine and cannabis in a longitudinal, population sample of adolescents and young adults, at the period of highest increase in drug use. METHODS: Data from the prospective population-based Great Smoky Mountains Study (N=1420) were used, covering children in the community assessed at ages 9-16, 19, and 21. Structured interviews were used to assess substance abuse symptoms and DSM-IV substance use disorders. Bloodspots were collected at each assessment and assayed for CRP. RESULTS: CRP levels were higher in the presence of nicotine, alcohol, and cannabis use and nicotine dependence. In prospective analyses, higher CRP levels predicted cannabis use and nicotine dependence, and nicotine use predicted higher CRP levels, once covariates were included in the models. Significant covariates were age, race (American Indian), and obesity. CONCLUSIONS: The inter-relationship of CRP and substance abuse has implications for the later health risks associated with early drug and alcohol use and abuse.

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Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

December 1, 2013

Volume

133

Issue

2

Start / End Page

712 / 717

Location

Ireland

Related Subject Headings

  • Young Adult
  • Substance-Related Disorders
  • Substance Abuse
  • Stress, Psychological
  • Socioeconomic Factors
  • Sex Factors
  • Regression Analysis
  • Prospective Studies
  • Obesity
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Costello, E. J., Copeland, W. E., Shanahan, L., Worthman, C. M., & Angold, A. (2013). C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis. Drug Alcohol Depend, 133(2), 712–717. https://doi.org/10.1016/j.drugalcdep.2013.08.027
Costello, E Jane, William E. Copeland, Lilly Shanahan, Carol M. Worthman, and Adrian Angold. “C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.Drug Alcohol Depend 133, no. 2 (December 1, 2013): 712–17. https://doi.org/10.1016/j.drugalcdep.2013.08.027.
Costello EJ, Copeland WE, Shanahan L, Worthman CM, Angold A. C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis. Drug Alcohol Depend. 2013 Dec 1;133(2):712–7.
Costello, E. Jane, et al. “C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.Drug Alcohol Depend, vol. 133, no. 2, Dec. 2013, pp. 712–17. Pubmed, doi:10.1016/j.drugalcdep.2013.08.027.
Costello EJ, Copeland WE, Shanahan L, Worthman CM, Angold A. C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis. Drug Alcohol Depend. 2013 Dec 1;133(2):712–717.
Journal cover image

Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

December 1, 2013

Volume

133

Issue

2

Start / End Page

712 / 717

Location

Ireland

Related Subject Headings

  • Young Adult
  • Substance-Related Disorders
  • Substance Abuse
  • Stress, Psychological
  • Socioeconomic Factors
  • Sex Factors
  • Regression Analysis
  • Prospective Studies
  • Obesity
  • Male