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The role of cognitive functioning in medication adherence of children and adolescents with HIV infection.

Publication ,  Journal Article
Malee, K; Williams, PL; Montepiedra, G; Nichols, S; Sirois, PA; Storm, D; Farley, J; Kammerer, B; PACTG 219C Team,
Published in: J Pediatr Psychol
March 2009

OBJECTIVE: To evaluate the relationship between cognitive functioning and medication adherence in children and adolescents with perinatally acquired HIV infection. METHODS: Children and adolescents, ages 3-18 (N = 1,429), received a cognitive evaluation and adherence assessment. Multiple logistic regression models were used to identify associations between adherence and cognitive status, adjusting for potential confounding factors. RESULTS: Children's average cognitive performance was within the low-average range; 16% of children were cognitively impaired (MDI/FSIQ <70). Cognitive status was not associated with adherence to full medication regimens; however, children with borderline/low average cognitive functioning (IQ 70-84) had increased odds of nonadherence to the protease inhibitor class of antiretroviral therapy. Recent stressful life events and child health characteristics, such as HIV RNA detectability, were significantly associated with nonadherence. CONCLUSION: Cognitive status plays a limited role in medication adherence. Child and caregiver psychosocial and health characteristics should inform interventions to support adherence.

Duke Scholars

Published In

J Pediatr Psychol

DOI

EISSN

1465-735X

Publication Date

March 2009

Volume

34

Issue

2

Start / End Page

164 / 175

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prospective Studies
  • Patient Compliance
  • Neuropsychological Tests
  • Male
  • Intelligence Tests
  • Humans
  • HIV Infections
  • Female
  • Developmental & Child Psychology
 

Citation

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Malee, K., Williams, P. L., Montepiedra, G., Nichols, S., Sirois, P. A., Storm, D., … PACTG 219C Team, . (2009). The role of cognitive functioning in medication adherence of children and adolescents with HIV infection. J Pediatr Psychol, 34(2), 164–175. https://doi.org/10.1093/jpepsy/jsn068
Malee, Kathleen, Paige L. Williams, Grace Montepiedra, Sharon Nichols, Patricia A. Sirois, Deborah Storm, John Farley, Betsy Kammerer, and Betsy PACTG 219C Team. “The role of cognitive functioning in medication adherence of children and adolescents with HIV infection.J Pediatr Psychol 34, no. 2 (March 2009): 164–75. https://doi.org/10.1093/jpepsy/jsn068.
Malee K, Williams PL, Montepiedra G, Nichols S, Sirois PA, Storm D, et al. The role of cognitive functioning in medication adherence of children and adolescents with HIV infection. J Pediatr Psychol. 2009 Mar;34(2):164–75.
Malee, Kathleen, et al. “The role of cognitive functioning in medication adherence of children and adolescents with HIV infection.J Pediatr Psychol, vol. 34, no. 2, Mar. 2009, pp. 164–75. Pubmed, doi:10.1093/jpepsy/jsn068.
Malee K, Williams PL, Montepiedra G, Nichols S, Sirois PA, Storm D, Farley J, Kammerer B, PACTG 219C Team. The role of cognitive functioning in medication adherence of children and adolescents with HIV infection. J Pediatr Psychol. 2009 Mar;34(2):164–175.
Journal cover image

Published In

J Pediatr Psychol

DOI

EISSN

1465-735X

Publication Date

March 2009

Volume

34

Issue

2

Start / End Page

164 / 175

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prospective Studies
  • Patient Compliance
  • Neuropsychological Tests
  • Male
  • Intelligence Tests
  • Humans
  • HIV Infections
  • Female
  • Developmental & Child Psychology