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No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis.

Publication ,  Journal Article
Zhu, M-L; Wang, M; Shi, T-Y; Li, Q-X; Xi, P; Xia, K-Q; Zheng, L; Wei, Q-Y
Published in: PLoS One
2013

BACKGROUND: Transforming growth factor-beta 1 (TGF-β1) protein may be multifunctional and related to the development of fibrosis, induction of apoptosis, extracellular signaling and inhibition of proliferation in response to radiation-induced DNA damage. Several studies have investigated associations between single nucleotide polymorphisms (SNPs) in the TGFB1 gene and risk of late radiation-induced injury of normal tissue, but the conclusions remain controversial. METHODS: We searched three electronic databases (i.e., MEDLINE, EMBASE and EBSCO) for eligible publications and performed a meta-analysis assessing the association of three commonly studied SNPs in TGFB1 (i.e., rs1800469, rs1800470 and rs1800471) with risk of late radiation-induced injury of normal tissue. RESULTS: We finally included 28 case-only studies from 16 publications on aforementioned SNPs in TGFB1. However, we did not find statistical evidence of any significant association with overall risk of late radiotherapy toxicity in the pooled analysis or in further stratified analysis by cancer type, endpoint, ethnicity and sample size. CONCLUSIONS: This meta-analysis did not find statistical evidence for an association between SNPs in TGFB1 and risk of late radiation-induced injury of normal tissue, but this finding needs further confirmation by a single large study.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

10

Start / End Page

e76964

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta1
  • Time Factors
  • Radiotherapy
  • Radiation Injuries
  • Polymorphism, Single Nucleotide
  • Humans
  • Genetic Predisposition to Disease
  • General Science & Technology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhu, M.-L., Wang, M., Shi, T.-Y., Li, Q.-X., Xi, P., Xia, K.-Q., … Wei, Q.-Y. (2013). No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis. PLoS One, 8(10), e76964. https://doi.org/10.1371/journal.pone.0076964
Zhu, Mei-Ling, MengYun Wang, Ting-Yan Shi, Qiao-Xin Li, Pan Xi, Kai-Qin Xia, Leizhen Zheng, and Qing-Yi Wei. “No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis.PLoS One 8, no. 10 (2013): e76964. https://doi.org/10.1371/journal.pone.0076964.
Zhu M-L, Wang M, Shi T-Y, Li Q-X, Xi P, Xia K-Q, et al. No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis. PLoS One. 2013;8(10):e76964.
Zhu, Mei-Ling, et al. “No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis.PLoS One, vol. 8, no. 10, 2013, p. e76964. Pubmed, doi:10.1371/journal.pone.0076964.
Zhu M-L, Wang M, Shi T-Y, Li Q-X, Xi P, Xia K-Q, Zheng L, Wei Q-Y. No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis. PLoS One. 2013;8(10):e76964.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

10

Start / End Page

e76964

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta1
  • Time Factors
  • Radiotherapy
  • Radiation Injuries
  • Polymorphism, Single Nucleotide
  • Humans
  • Genetic Predisposition to Disease
  • General Science & Technology