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SIV-induced instability of the chimpanzee gut microbiome.

Publication ,  Journal Article
Moeller, AH; Shilts, M; Li, Y; Rudicell, RS; Lonsdorf, EV; Pusey, AE; Wilson, ML; Hahn, BH; Ochman, H
Published in: Cell host & microbe
September 2013

Simian immunodeficiency virus of chimpanzees (SIVcpz) is the ancestor of human immunodeficiency virus type 1 (HIV-1), the etiologic agent of acquired immunodeficiency syndrome (AIDS) in humans. Like HIV-1-infected humans, SIVcpz-infected chimpanzees can develop AIDS-like symptoms. Because SIVcpz/HIV-1 may disrupt regulation of the gut microbiome and because it has not been possible to sample individual humans pre- and postinfection, we investigated the influence of infection on gut communities through long-term monitoring of chimpanzees from Gombe National Park, Tanzania. SIVcpz infection accelerated the rate of change in gut microbiota composition within individuals for periods of years after the initial infection and led to gut communities marked by high frequencies of pathogen-containing bacterial genera absent from SIVcpz-negative individuals. Our results indicate that immune function maintains temporally stable gut communities that are lost when individuals become infected with SIVcpz.

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Published In

Cell host & microbe

DOI

EISSN

1934-6069

ISSN

1931-3128

Publication Date

September 2013

Volume

14

Issue

3

Start / End Page

340 / 345

Related Subject Headings

  • Tanzania
  • Simian Acquired Immunodeficiency Syndrome
  • Sequence Analysis, DNA
  • RNA, Ribosomal, 16S
  • Pan troglodytes
  • Molecular Sequence Data
  • Immunology
  • Gastrointestinal Tract
  • Feces
  • Dysbiosis
 

Citation

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Moeller, A. H., Shilts, M., Li, Y., Rudicell, R. S., Lonsdorf, E. V., Pusey, A. E., … Ochman, H. (2013). SIV-induced instability of the chimpanzee gut microbiome. Cell Host & Microbe, 14(3), 340–345. https://doi.org/10.1016/j.chom.2013.08.005
Moeller, Andrew H., Meghan Shilts, Yingying Li, Rebecca S. Rudicell, Elizabeth V. Lonsdorf, Anne E. Pusey, Michael L. Wilson, Beatrice H. Hahn, and Howard Ochman. “SIV-induced instability of the chimpanzee gut microbiome.Cell Host & Microbe 14, no. 3 (September 2013): 340–45. https://doi.org/10.1016/j.chom.2013.08.005.
Moeller AH, Shilts M, Li Y, Rudicell RS, Lonsdorf EV, Pusey AE, et al. SIV-induced instability of the chimpanzee gut microbiome. Cell host & microbe. 2013 Sep;14(3):340–5.
Moeller, Andrew H., et al. “SIV-induced instability of the chimpanzee gut microbiome.Cell Host & Microbe, vol. 14, no. 3, Sept. 2013, pp. 340–45. Epmc, doi:10.1016/j.chom.2013.08.005.
Moeller AH, Shilts M, Li Y, Rudicell RS, Lonsdorf EV, Pusey AE, Wilson ML, Hahn BH, Ochman H. SIV-induced instability of the chimpanzee gut microbiome. Cell host & microbe. 2013 Sep;14(3):340–345.
Journal cover image

Published In

Cell host & microbe

DOI

EISSN

1934-6069

ISSN

1931-3128

Publication Date

September 2013

Volume

14

Issue

3

Start / End Page

340 / 345

Related Subject Headings

  • Tanzania
  • Simian Acquired Immunodeficiency Syndrome
  • Sequence Analysis, DNA
  • RNA, Ribosomal, 16S
  • Pan troglodytes
  • Molecular Sequence Data
  • Immunology
  • Gastrointestinal Tract
  • Feces
  • Dysbiosis