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A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity.

Publication ,  Journal Article
Nickens, KP; Wikstrom, JD; Shirihai, OS; Patierno, SR; Ceryak, S
Published in: Mitochondrion
November 2013

Apoptosis-resistance and metabolic imbalances are prominent features of cancer cells. We have recently reported on populations of human fibroblasts that exhibit resistance to mitochondrial-mediated apoptosis, acquired as a result of a single genotoxic exposure. The objective of the present study was to investigate the intrinsic bioenergetic profile of the death-resistant cells, as compared to the clonogenic control cells. Therefore, we analyzed the basic bioenergetic parameters including oxygen consumption and extracellular acidification rates, coupling efficiency, and spare respiratory capacity. Our data demonstrate a strong correlation between enhanced spare respiratory capacity and death-resistance, which we postulate to be indicative of the earliest stages of carcinogenesis.

Duke Scholars

Published In

Mitochondrion

DOI

EISSN

1872-8278

Publication Date

November 2013

Volume

13

Issue

6

Start / End Page

662 / 667

Location

Netherlands

Related Subject Headings

  • Humans
  • Fibroblasts
  • Energy Metabolism
  • Electron Transport
  • Cell Line
  • Cell Death
  • Biochemistry & Molecular Biology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0604 Genetics
 

Citation

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Chicago
ICMJE
MLA
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Nickens, K. P., Wikstrom, J. D., Shirihai, O. S., Patierno, S. R., & Ceryak, S. (2013). A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. Mitochondrion, 13(6), 662–667. https://doi.org/10.1016/j.mito.2013.09.005
Nickens, Kristen P., Jakob D. Wikstrom, Orian S. Shirihai, Steven R. Patierno, and Susan Ceryak. “A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity.Mitochondrion 13, no. 6 (November 2013): 662–67. https://doi.org/10.1016/j.mito.2013.09.005.
Nickens KP, Wikstrom JD, Shirihai OS, Patierno SR, Ceryak S. A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. Mitochondrion. 2013 Nov;13(6):662–7.
Nickens, Kristen P., et al. “A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity.Mitochondrion, vol. 13, no. 6, Nov. 2013, pp. 662–67. Pubmed, doi:10.1016/j.mito.2013.09.005.
Nickens KP, Wikstrom JD, Shirihai OS, Patierno SR, Ceryak S. A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. Mitochondrion. 2013 Nov;13(6):662–667.
Journal cover image

Published In

Mitochondrion

DOI

EISSN

1872-8278

Publication Date

November 2013

Volume

13

Issue

6

Start / End Page

662 / 667

Location

Netherlands

Related Subject Headings

  • Humans
  • Fibroblasts
  • Energy Metabolism
  • Electron Transport
  • Cell Line
  • Cell Death
  • Biochemistry & Molecular Biology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0604 Genetics