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Synthesis and structural studies of new polyhydroxamic iron(III) complexes for the use in nuclear magnetic resonance imaging. Part II: Study of the complexes formed in situ from hydroxamic acids

Publication ,  Journal Article
Chaubet, F; Nguyen Van Duong, K; Courtieu, J; Gaudemer, A; Gref, A; Crumbliss, AL; Caudle, MT
Published in: Canadian Journal of Chemistry
January 1, 1994

Numerous analogous dihydroxamates of rhodotorulic acid have been prepared, and their mode of complexation of iron(III) and the stability of these complexes studied as a function of pH, for comparison wimh ferrioxamine B and the complex of acetohydroxamic acid with iron(III). This study has shown that the stoichiometry of the complexes is 2:3 (at a pH of 7) and 1:1 (at a pH of 2), and that, in spite of a complete complexation, their electrochemical behaviour varies greatly with pH. The very strong complexation constant observed (log β110 = 21.3) at a pH of 1 with the ligand N,N'-bis(acetylhydroxamino-3' propyl)-pentyloxy-4 pyridine-2,6-dicarboxamide confirms the strong complexation capacity of iron(III) by these complexes. The high relaxivity of the complex of iron(III) with the N,N'-bis(acetylhydroxyamino-3'-propyl)-(amino-4''-butyloxy)-4-pyridine -2,6-dicarboxamide suggests that this product could be a useful contrasting agent for nuclear magnetic imaging.

Duke Scholars

Published In

Canadian Journal of Chemistry

DOI

ISSN

0008-4042

Publication Date

January 1, 1994

Volume

72

Issue

12

Start / End Page

2361 / 2368

Related Subject Headings

  • General Chemistry
  • 03 Chemical Sciences
 

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Chaubet, F., Nguyen Van Duong, K., Courtieu, J., Gaudemer, A., Gref, A., Crumbliss, A. L., & Caudle, M. T. (1994). Synthesis and structural studies of new polyhydroxamic iron(III) complexes for the use in nuclear magnetic resonance imaging. Part II: Study of the complexes formed in situ from hydroxamic acids. Canadian Journal of Chemistry, 72(12), 2361–2368. https://doi.org/10.1139/v94-302
Chaubet, F., K. Nguyen Van Duong, J. Courtieu, A. Gaudemer, A. Gref, A. L. Crumbliss, and M. T. Caudle. “Synthesis and structural studies of new polyhydroxamic iron(III) complexes for the use in nuclear magnetic resonance imaging. Part II: Study of the complexes formed in situ from hydroxamic acids.” Canadian Journal of Chemistry 72, no. 12 (January 1, 1994): 2361–68. https://doi.org/10.1139/v94-302.
Chaubet F, Nguyen Van Duong K, Courtieu J, Gaudemer A, Gref A, Crumbliss AL, et al. Synthesis and structural studies of new polyhydroxamic iron(III) complexes for the use in nuclear magnetic resonance imaging. Part II: Study of the complexes formed in situ from hydroxamic acids. Canadian Journal of Chemistry. 1994 Jan 1;72(12):2361–8.
Chaubet, F., et al. “Synthesis and structural studies of new polyhydroxamic iron(III) complexes for the use in nuclear magnetic resonance imaging. Part II: Study of the complexes formed in situ from hydroxamic acids.” Canadian Journal of Chemistry, vol. 72, no. 12, Jan. 1994, pp. 2361–68. Scopus, doi:10.1139/v94-302.
Chaubet F, Nguyen Van Duong K, Courtieu J, Gaudemer A, Gref A, Crumbliss AL, Caudle MT. Synthesis and structural studies of new polyhydroxamic iron(III) complexes for the use in nuclear magnetic resonance imaging. Part II: Study of the complexes formed in situ from hydroxamic acids. Canadian Journal of Chemistry. 1994 Jan 1;72(12):2361–2368.

Published In

Canadian Journal of Chemistry

DOI

ISSN

0008-4042

Publication Date

January 1, 1994

Volume

72

Issue

12

Start / End Page

2361 / 2368

Related Subject Headings

  • General Chemistry
  • 03 Chemical Sciences