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Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account.

Publication ,  Journal Article
Tantry, US; Mahla, E; Gesheff, MG; Gurbel, PA
Published in: Expert Rev Cardiovasc Ther
November 2013

The pivotal roles of platelets in physiological hemostasis and pathological thrombosis at the site of plaque rupture are well established. The latter roles provide the fundamental basis for the most widely implemented pharmacologic management of coronary artery disease--dual antiplatelet therapy with aspirin to inhibit platelet thromboxane A2 generation, and a P2Y12 receptor inhibitor to prevent adenosine diphosphate (ADP)-induced platelet activation. Although suboptimal pharmacodynamic efficacy, also described as high on-treatment platelet reactivity to ADP, has been associated with greater risk for post-stenting ischemic event occurrence, enhanced responsiveness is associated with higher risk for bleeding in selected patients. In this review article, we aim to provide an historical account of the one and a half century long journey starting with the first description of platelets through the first report of ex vivo measurement of ADP-induced platelet aggregation, the first demonstration of an association between ADP-induced platelet aggregation and post-stenting ischemic event occurrence, and finally to the most recent description of a 'therapeutic window' concept for P2Y12 receptor inhibitor therapy.

Duke Scholars

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

November 2013

Volume

11

Issue

11

Start / End Page

1547 / 1556

Location

England

Related Subject Headings

  • Stents
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Platelet Activation
  • Humans
  • Drug Therapy, Combination
  • Coronary Artery Disease
  • Cardiovascular System & Hematology
  • Blood Platelets
  • Aspirin
 

Citation

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Tantry, U. S., Mahla, E., Gesheff, M. G., & Gurbel, P. A. (2013). Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account. Expert Rev Cardiovasc Ther, 11(11), 1547–1556. https://doi.org/10.1586/14779072.2013.839382
Tantry, Udaya S., Elisabeth Mahla, Martin G. Gesheff, and Paul A. Gurbel. “Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account.Expert Rev Cardiovasc Ther 11, no. 11 (November 2013): 1547–56. https://doi.org/10.1586/14779072.2013.839382.
Tantry US, Mahla E, Gesheff MG, Gurbel PA. Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account. Expert Rev Cardiovasc Ther. 2013 Nov;11(11):1547–56.
Tantry, Udaya S., et al. “Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account.Expert Rev Cardiovasc Ther, vol. 11, no. 11, Nov. 2013, pp. 1547–56. Pubmed, doi:10.1586/14779072.2013.839382.
Tantry US, Mahla E, Gesheff MG, Gurbel PA. Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account. Expert Rev Cardiovasc Ther. 2013 Nov;11(11):1547–1556.
Journal cover image

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

November 2013

Volume

11

Issue

11

Start / End Page

1547 / 1556

Location

England

Related Subject Headings

  • Stents
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Platelet Activation
  • Humans
  • Drug Therapy, Combination
  • Coronary Artery Disease
  • Cardiovascular System & Hematology
  • Blood Platelets
  • Aspirin