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Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.

Publication ,  Journal Article
Pollara, J; Bonsignori, M; Moody, MA; Pazgier, M; Haynes, BF; Ferrari, G
Published in: Curr HIV Res
July 2013

Antibody dependent cellular cytotoxicity [ADCC] has been suggested to play an important role in control of Human Immunodeficiency Virus-1 [HIV-1] viral load and protection from infection. ADCC antibody responses have been mapped to multiple linear and conformational epitopes within the HIV-1 envelope glycoproteins gp120 and gp41. Many epitopes targeted by antibodies that mediate ADCC overlap with those recognized by antibodies capable of virus neutralization. In addition, recent studies conducted with human monoclonal antibodies derived from HIV-1 infected individuals and HIV-1 vaccine-candidate vaccinees have identified a number of antibodies that lack the ability to capture primary HIV-1 isolates or mediate neutralizing activity, but are able to bind to the surface of infected CD4+ T cells and mediate ADCC. Of note, the conformational changes in the gp120 that may not exclusively relate to binding of the CD4 molecule are important in exposing epitopes recognized by ADCC responses. Here we discuss the HIV-1 envelope epitopes targeted by ADCC antibodies in the context of the potential protective capacities of ADCC.

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Published In

Curr HIV Res

DOI

EISSN

1873-4251

Publication Date

July 2013

Volume

11

Issue

5

Start / End Page

378 / 387

Location

Netherlands

Related Subject Headings

  • Virology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp41
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • Epitopes, T-Lymphocyte
  • Antibody-Dependent Cell Cytotoxicity
  • Antibody Specificity
 

Citation

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Pollara, J., Bonsignori, M., Moody, M. A., Pazgier, M., Haynes, B. F., & Ferrari, G. (2013). Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses. Curr HIV Res, 11(5), 378–387. https://doi.org/10.2174/1570162x113116660059
Pollara, Justin, Mattia Bonsignori, M Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. “Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.Curr HIV Res 11, no. 5 (July 2013): 378–87. https://doi.org/10.2174/1570162x113116660059.
Pollara J, Bonsignori M, Moody MA, Pazgier M, Haynes BF, Ferrari G. Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses. Curr HIV Res. 2013 Jul;11(5):378–87.
Pollara, Justin, et al. “Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.Curr HIV Res, vol. 11, no. 5, July 2013, pp. 378–87. Pubmed, doi:10.2174/1570162x113116660059.
Pollara J, Bonsignori M, Moody MA, Pazgier M, Haynes BF, Ferrari G. Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses. Curr HIV Res. 2013 Jul;11(5):378–387.

Published In

Curr HIV Res

DOI

EISSN

1873-4251

Publication Date

July 2013

Volume

11

Issue

5

Start / End Page

378 / 387

Location

Netherlands

Related Subject Headings

  • Virology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp41
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • Epitopes, T-Lymphocyte
  • Antibody-Dependent Cell Cytotoxicity
  • Antibody Specificity