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Activation and evasion of antiviral innate immunity by hepatitis C virus.

Publication ,  Journal Article
Horner, SM
Published in: J Mol Biol
March 20, 2014

Hepatitis C virus (HCV) chronically infects 130-170 million people worldwide and is a major public health burden. HCV is an RNA virus that infects hepatocytes within liver, and this infection is sensed as non-self by the intracellular innate immune response to program antiviral immunity to HCV. HCV encodes several strategies to evade this antiviral response, and this evasion of innate immunity plays a key role in determining viral persistence. This review discusses the molecular mechanisms of how the intracellular innate immune system detects HCV infection, including how HCV pathogen-associated molecular patterns are generated during infection and where they are recognized as foreign by the innate immune system. Further, this review highlights the key innate immune evasion strategies used by HCV to establish persistent infection within the liver, as well as how host genotype influences the outcome of HCV infection. Understanding these HCV-host interactions is key in understanding how to target HCV during infection and for the design of more effective HCV therapies at the immunological level.

Duke Scholars

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Published In

J Mol Biol

DOI

EISSN

1089-8638

Publication Date

March 20, 2014

Volume

426

Issue

6

Start / End Page

1198 / 1209

Location

Netherlands

Related Subject Headings

  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Hepatitis C
  • Hepacivirus
  • Biochemistry & Molecular Biology
  • Antiviral Agents
  • Animals
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
 

Citation

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Horner, S. M. (2014). Activation and evasion of antiviral innate immunity by hepatitis C virus. J Mol Biol, 426(6), 1198–1209. https://doi.org/10.1016/j.jmb.2013.10.032
Horner, Stacy M. “Activation and evasion of antiviral innate immunity by hepatitis C virus.J Mol Biol 426, no. 6 (March 20, 2014): 1198–1209. https://doi.org/10.1016/j.jmb.2013.10.032.
Horner SM. Activation and evasion of antiviral innate immunity by hepatitis C virus. J Mol Biol. 2014 Mar 20;426(6):1198–209.
Horner, Stacy M. “Activation and evasion of antiviral innate immunity by hepatitis C virus.J Mol Biol, vol. 426, no. 6, Mar. 2014, pp. 1198–209. Pubmed, doi:10.1016/j.jmb.2013.10.032.
Horner SM. Activation and evasion of antiviral innate immunity by hepatitis C virus. J Mol Biol. 2014 Mar 20;426(6):1198–1209.
Journal cover image

Published In

J Mol Biol

DOI

EISSN

1089-8638

Publication Date

March 20, 2014

Volume

426

Issue

6

Start / End Page

1198 / 1209

Location

Netherlands

Related Subject Headings

  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Hepatitis C
  • Hepacivirus
  • Biochemistry & Molecular Biology
  • Antiviral Agents
  • Animals
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology