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Cogan's Syndrome

Publication ,  Journal Article
McCallum, RM; St. Clair, EW
May 3, 2012

Cogan's syndrome (CS) is characterized by interstitial keratitis, which rarely produces blindness, and recurrent Meniere's-like vestibulo-auditory events with frequent progression to hearing loss and deafness. It is a rare disease with a mean age of onset at 29 years. The mortality rate is unknown. Approximately half of the patients report an antecedent upper respiratory illness. Inflammatory cardiovascular disease develops in 15% of patients. The diagnosis of CS requires the presence of ocular inflammation and inner ear dysfunction not explained by another illness. Because the differential diagnostic considerations in CS cross a broad spectrum of illnesses and toxicities, the proper assessment of CS and its management often requires the collaboration of numerous specialties. The exact etiology of CS remains a mystery, although immune mechanisms likely have a pivotal role in its pathogenesis. Treatment consists typically of corticosteroids and the judicious use of other immunosuppressive therapies. © 2012 Blackwell Publishing Ltd.

Duke Scholars

DOI

Publication Date

May 3, 2012

Start / End Page

299 / 311
 

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McCallum, R. M., & St. Clair, E. W. (2012). Cogan's Syndrome, 299–311. https://doi.org/10.1002/9781118355244.ch27
McCallum, R. M., and E. W. St. Clair. “Cogan's Syndrome,” May 3, 2012, 299–311. https://doi.org/10.1002/9781118355244.ch27.
McCallum RM, St. Clair EW. Cogan's Syndrome. 2012 May 3;299–311.
McCallum, R. M., and E. W. St. Clair. Cogan's Syndrome. May 2012, pp. 299–311. Scopus, doi:10.1002/9781118355244.ch27.
McCallum RM, St. Clair EW. Cogan's Syndrome. 2012 May 3;299–311.

DOI

Publication Date

May 3, 2012

Start / End Page

299 / 311