Biological products

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  Subject Areas on Research

  • 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. 
  • 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. 
  • A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues. 
  • A comparison of moment-based and probability-based criteria for assessment of follow-on biologics. 
  • A comprehensive review of topical hemostatic agents: efficacy and recommendations for use. 
  • A general strategy for construction of both 2,6-cis- and 2,6-trans-disubstituted tetrahydropyrans: substrate-controlled asymmetric total synthesis of (+)-scanlonenyne. 
  • ACCF/AHA 2011 health policy statement on therapeutic interchange and substitution: a report of the American College of Cardiology Foundation Clinical Quality Committee. 
  • Absence of macrophage involvement in the passive serum therapy of Friend leukemia virus-induced disease. 
  • Advances in Wound Management. 
  • Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A. 
  • Advances in the treatment of inflammatory arthritis. 
  • An overview of naturally occurring histone deacetylase inhibitors. 
  • Anisotropic wetting surfaces with one-dimensional and directional structures: fabrication approaches, wetting properties and potential applications. 
  • Application of the parallel line assay to assessment of biosimilar products based on binary endpoints. 
  • Biologics in organ transplantation. 
  • C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products. 
  • Cancer and Leukemia Group B/Southwest Oncology Group trial 80405: a phase III trial of chemotherapy and biologics for patients with untreated advanced colorectal adenocarcinoma. 
  • Catalytic enantioselective alkylation of substituted dioxanone enol ethers: ready access to Calpha-tetrasubstituted hydroxyketones, acids, and esters. 
  • Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more. 
  • Chemical logic of MraY inhibition by antibacterial nucleoside natural products. 
  • Clinical Features and Treatment of Down Syndrome Arthropathy: Experience from Two US Tertiary Hospitals. 
  • Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control. 
  • Comparative effectiveness of nonbiologic versus biologic disease-modifying antirheumatic drugs for rheumatoid arthritis. 
  • Comparative effectiveness of surfactant preparations in premature infants. 
  • Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions. 
  • Controlled release of biologics for the treatment of type 2 diabetes. 
  • Decreased use of non-steroidal anti-inflammatory drugs for the treatment of juvenile idiopathic arthritis in the era of modern aggressive treatment. 
  • Design and stereoselective preparation of a new class of chiral olefin metathesis catalysts and application to enantioselective synthesis of quebrachamine: catalyst development inspired by natural product synthesis. 
  • Design considerations, architecture, and use of the Mini-Sentinel distributed data system. 
  • Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements. 
  • Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. 
  • Evaluation of the Performance of a Nature-Based Sensitive Skin Regimen in Subjects With Clinically Diagnosed Sensitive Skin. 
  • Factors Associated With Initiation of Biologics in Patients With Axial Spondyloarthritis in an Urban Asian City: A PRESPOND Study. 
  • Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation. 
  • Infection is the major trigger of hemophagocytic syndrome in adult patients treated with biological therapies. 
  • Largazole: from discovery to broad-spectrum therapy. 
  • Letter to the Editor Regarding Optimizing Selection of Biologics in Inflammatory Bowel Disease: Development of an Online Patient Decision Aid Using Conjoint Analysis. 
  • Microglassification™: a novel technique for protein dehydration. 
  • Modest advances in survival for patients with colorectal-associated peritoneal carcinomatosis in the era of modern chemotherapy. 
  • Natural Skin Care Products as Adjunctive to Prescription Therapy in Moderate to Severe Rosacea 
  • Natural product synthesis at the interface of chemistry and biology. 
  • New and Pipeline Drugs for Gout. 
  • Patient preferences for biologic agents in rheumatoid arthritis: a discrete-choice experiment. 
  • Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. 
  • Prescription patterns for children with juvenile idiopathic arthritis in Michigan Medicaid: a comparison by prescriber type. 
  • Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. 
  • Radical Breakthroughs in Natural Product and Cofactor Biosynthesis. 
  • Reply to Vanhove et al. 
  • Revisiting the Cancer and Leukemia Group B/Southwest Oncology Group 80405 Trial: a phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma. 
  • Rheumatology Informatics System for Effectiveness: A National Informatics-Enabled Registry for Quality Improvement. 
  • Role of natural product diversity in chemical biology. 
  • Self-reported pain and disease symptoms persist in juvenile idiopathic arthritis despite treatment advances: an electronic diary study. 
  • Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant. 
  • Statistical and regulatory considerations in assessments of interchangeability of biological drug products. 
  • Statistical assessment of biosimilar products. 
  • Statistical methods for assessment of biosimilarity using biomarker data. 
  • Statistical test for evaluation of biosimilarity in variability of follow-on biologics. 
  • Synthesis of α,α'-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction. 
  • Synthetic efforts towards the stereoselective synthesis of NF00659B1. 
  • Systematic assignment of the configuration of flexible natural products by spectroscopic and computational methods: the bistramide C analysis. 
  • Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions. 
  • Technological Advances, Biologic Rationales, and the Associated Success of Chemotherapy With Hyperthermia in Improved Outcomes in Patients With Sarcoma. 
  • The Future Is Now: Biologics for Non-Infectious Pediatric Anterior Uveitis. 
  • The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013. 
  • The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction. 
  • The impact of specialty pharmaceuticals as drivers of health care costs. 
  • Therapy of rheumatoid arthritis: new developments and trends. 
  • There is a role for industry-sponsored education in cardiology. 
  • Three-dimensional reconstruction of tubular myelin. 
  • Tides of inflammation: impact of biologics. 
  • Total synthesis of (-)-hennoxazole A. 
  • Treatment of juvenile idiopathic arthritis-associated uveitis: challenges and update. 
  • Using Medicare administrative data to conduct postmarketing surveillance of follow-on biologics: issues and opportunities. 
  • Using registries to identify adverse events in rheumatic diseases. 
  • Ventricular assist devices and increased blood product utilization for cardiac transplantation. 
  • What's next in the pipeline. 
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  Keywords of People

  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics