Carcinogenesis

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  Subject Areas on Research

  • A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. 
  • A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. 
  • A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion. 
  • A medical-toxicological view of tattooing. 
  • Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin-mediated prostatic tumorigenesis. 
  • Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling. 
  • Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease. 
  • Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis. 
  • Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer. 
  • Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. 
  • An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. 
  • An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. 
  • An ultra-sensitive method to detect mutations in human RAS templates. 
  • Analysis of post-transcriptional regulation during cancer progression using a donor-derived isogenic model of tumorigenesis. 
  • Androgen receptor with short polyglutamine tract preferably enhances Wnt/β-catenin-mediated prostatic tumorigenesis. 
  • Apoptotic cell death in disease-Current understanding of the NCCD 2023. 
  • Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. 
  • BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. 
  • Bcl-xL is an oncogenic driver in colorectal cancer. 
  • CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping. 
  • CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy. 
  • Cancer clocks in tumourigenesis: the p53 pathway and beyond. 
  • Capturing the primordial Kras mutation initiating urethane carcinogenesis. 
  • Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. 
  • Cell and extracellular matrix growth theory and its implications for tumorigenesis. 
  • Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. 
  • Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice. 
  • Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors 
  • DOK2 inhibits EGFR-mutated lung adenocarcinoma. 
  • Decreased tumorigenesis in mice with a Kras point mutation at C118. 
  • Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. 
  • Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis. 
  • Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis. 
  • Differential Cell Susceptibilities to KrasG12D in the Setting of Obstructive Chronic Pancreatitis. 
  • Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model. 
  • Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. 
  • Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. 
  • Dysregulated metabolism contributes to oncogenesis. 
  • Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. 
  • EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. 
  • ETC-159, an Upstream Wnt inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma. 
  • Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men. 
  • Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. 
  • Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis. 
  • Evidence for a Novel Endometrioid Carcinogenic Sequence in the Fallopian Tube With Unique Beta-Catenin Expression. 
  • Evidence for and against epithelial-to-mesenchymal transition in the liver. 
  • Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. 
  • Frequent BRAF mutations suggest a novel oncogenic driver in colonic neuroendocrine carcinoma. 
  • Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk. 
  • Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis. 
  • HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase. 
  • High yield reproducible rat model recapitulating human Barrett's carcinogenesis. 
  • High-fructose corn syrup enhances intestinal tumor growth in mice. 
  • Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells. 
  • Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. 
  • Immunity to commensal papillomaviruses protects against skin cancer. 
  • Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1. 
  • Impact of HIV on lung tumorigenesis in an animal model. 
  • In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. 
  • Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition. 
  • Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. 
  • Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. 
  • Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX. 
  • Liver Tumor Microenvironment. 
  • LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling. 
  • LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. 
  • Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. 
  • Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets. 
  • Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis. 
  • Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. 
  • MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis. 
  • Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. 
  • Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? 
  • Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. 
  • Metabolism and Colorectal Cancer. 
  • Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. 
  • Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases. 
  • Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma. 
  • Mutational processes in cancer preferentially affect binding of particular transcription factors. 
  • Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening. 
  • Non-canonical genomic driver mutations of urethane carcinogenesis. 
  • Noncoding RNAs Regulating Cancer Signaling Network. 
  • Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting. 
  • Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. 
  • Oncogenic Signaling Pathways and Pathway-Based Therapeutic Biomarkers in Lymphoid Malignancies. 
  • Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling. 
  • Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. 
  • Osteopontin has a protective role in prostate tumor development in mice. 
  • PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. 
  • PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA. 
  • PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation. 
  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas. 
  • Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells. 
  • Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases. 
  • Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. 
  • Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer. 
  • Rare codons capacitate Kras-driven de novo tumorigenesis. 
  • Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. 
  • Reprogramming of cellular metabolic pathways by human oncogenic viruses. 
  • Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer. 
  • Role of exosomes in treatment of hepatocellular carcinoma. 
  • SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas. 
  • SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. 
  • SFPQ promotes an oncogenic transcriptomic state in melanoma. 
  • Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors. 
  • Signaling levels mold the RAS mutation tropism of urethane. 
  • Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival. 
  • Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation. 
  • Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer. 
  • Spatial Measures of Genetic Heterogeneity During Carcinogenesis. 
  • Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development. 
  • Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis. 
  • Suppressing oncogenic transcription with a little healthy competition. 
  • Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. 
  • The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. 
  • The DNA methylation landscape of advanced prostate cancer. 
  • The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. 
  • The Molecular Link from Diet to Cancer Cell Metabolism. 
  • The Oncogenesis in Patients With Pancreatic Intraductal Papillary Mucinous Neoplasms: Taking the Thread From the Beginning. 
  • The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis. 
  • The Role of Opioids and Their Receptors in Urological Malignancy: A Review. 
  • The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies. 
  • The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets. 
  • The whole-genome landscape of medulloblastoma subtypes. 
  • Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant. 
  • Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma. 
  • Tumour extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumour cells. 
  • VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. 
  • Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer. 
  • Wnt Signaling and Drug Resistance in Cancer. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology