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Subject Areas on Research
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A prospective view on phosphatases and replicative senescence.
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Acetate metabolism and aging: An emerging connection.
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Actin cytoskeletal network in aging and cancer.
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Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
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Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation.
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Autophagic activity dictates the cellular response to oncogenic RAS.
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Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position.
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CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.
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CD36 initiates the secretory phenotype during the establishment of cellular senescence.
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CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.
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Cell cycle control and cancer.
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Cell senescence reduced the mechanotransduction sensitivity of porcine angular aqueous plexus cells to elevation of pressure.
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Cellular senescence in the glaucomatous outflow pathway.
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Cellular senescence: from anti-cancer weapon to anti-aging target.
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Characterization of the absence of an unique DNA-binding protein in senescent but not in their young growing and nongrowing counterparts provides the means to mark the final stage of the cellular aging process.
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Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.
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Does senescence play a role in age-related macular degeneration?
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Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.
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EGF promotes mammalian cell growth by suppressing cellular senescence.
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Effects of donor age on proteasome activity and senescence in trabecular meshwork cells.
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Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.
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Evaluation of the spindle apparatus of in-vitro matured human oocytes following cryopreservation.
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Experience with subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) on unfertilized aged human oocytes.
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Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.
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Hepatitis C Virus, Inflammation, and Cellular Aging: Turning Back Time.
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INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.
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Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.
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Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence.
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In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye.
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Increased expression of senescence markers in cystic fibrosis airways.
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Induction of sodium channel clustering by oligodendrocytes.
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LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.
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Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation.
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Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence.
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Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.
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Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease.
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Melanoma proliferation and chemoresistance controlled by the DEK oncogene.
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Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.
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Multiplication of the SNCA locus exacerbates neuronal nuclear aging.
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Negative regulation of the tumor suppressor p53 gene by microRNAs.
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Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
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Novel human bronchial epithelial cell lines for cystic fibrosis research.
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Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.
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PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells.
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Pan-cancer analysis of whole genomes.
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Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.
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Phenotypic and cell cycle properties of human oligodendrocytes in vitro.
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Podocyte biology in segmental sclerosis and progressive glomerular injury.
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Premature T Cell Senescence in Pediatric CKD.
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Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis.
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Protocol to Generate Senescent Cells from the Mouse Hepatic Cell Line AML12 to Study Hepatic Aging.
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Redistribution and stabilization of cell surface glutamate receptors during synapse formation.
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Religiosity, depression and telomere length in Chinese older adults.
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Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.
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Restoration of p53 function leads to tumour regression in vivo.
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Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells.
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Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature.
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Senescent fibroblasts resist apoptosis by downregulating caspase-3.
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Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death.
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T-cell Dysfunction in Glioblastoma: Applying a New Framework.
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Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus
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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
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Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway.
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The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.
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The aged niche disrupts muscle stem cell quiescence.
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Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.
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Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes.
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Transcription errors induce proteotoxic stress and shorten cellular lifespan.
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Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway.
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Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process.
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Utility of telomerase-pot1 fusion protein in vascular tissue engineering.
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Wild-type p53: tumors can't stand it.
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c-Jun promotes whereas JunB inhibits epidermal neoplasia.
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c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.
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hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblasts.