Cellular Senescence

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  Subject Areas on Research

  • A prospective view on phosphatases and replicative senescence. 
  • Acetate metabolism and aging: An emerging connection. 
  • Actin cytoskeletal network in aging and cancer. 
  • Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. 
  • Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position. 
  • CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts. 
  • CD36 initiates the secretory phenotype during the establishment of cellular senescence. 
  • CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. 
  • Cell cycle control and cancer. 
  • Cell senescence reduced the mechanotransduction sensitivity of porcine angular aqueous plexus cells to elevation of pressure. 
  • Cellular senescence in the glaucomatous outflow pathway. 
  • Cellular senescence: from anti-cancer weapon to anti-aging target. 
  • Characterization of the absence of an unique DNA-binding protein in senescent but not in their young growing and nongrowing counterparts provides the means to mark the final stage of the cellular aging process. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Does senescence play a role in age-related macular degeneration? 
  • Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. 
  • EGF promotes mammalian cell growth by suppressing cellular senescence. 
  • Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. 
  • Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis. 
  • Evaluation of the spindle apparatus of in-vitro matured human oocytes following cryopreservation. 
  • Experience with subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) on unfertilized aged human oocytes. 
  • Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway. 
  • Hepatitis C Virus, Inflammation, and Cellular Aging: Turning Back Time. 
  • INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice. 
  • Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers. 
  • Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence. 
  • In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye. 
  • Increased expression of senescence markers in cystic fibrosis airways. 
  • Induction of sodium channel clustering by oligodendrocytes. 
  • LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. 
  • Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. 
  • Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence. 
  • Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis. 
  • Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. 
  • Melanoma proliferation and chemoresistance controlled by the DEK oncogene. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Multiplication of the SNCA locus exacerbates neuronal nuclear aging. 
  • Negative regulation of the tumor suppressor p53 gene by microRNAs. 
  • Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. 
  • Novel human bronchial epithelial cell lines for cystic fibrosis research. 
  • Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • Pan-cancer analysis of whole genomes. 
  • Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis. 
  • Phenotypic and cell cycle properties of human oligodendrocytes in vitro. 
  • Podocyte biology in segmental sclerosis and progressive glomerular injury. 
  • Premature T Cell Senescence in Pediatric CKD. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Protocol to Generate Senescent Cells from the Mouse Hepatic Cell Line AML12 to Study Hepatic Aging. 
  • Redistribution and stabilization of cell surface glutamate receptors during synapse formation. 
  • Religiosity, depression and telomere length in Chinese older adults. 
  • Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. 
  • Restoration of p53 function leads to tumour regression in vivo. 
  • Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells. 
  • Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. 
  • Senescent fibroblasts resist apoptosis by downregulating caspase-3. 
  • Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. 
  • T-cell Dysfunction in Glioblastoma: Applying a New Framework. 
  • Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus 
  • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. 
  • Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway. 
  • The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells. 
  • The aged niche disrupts muscle stem cell quiescence. 
  • Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. 
  • Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes. 
  • Transcription errors induce proteotoxic stress and shorten cellular lifespan. 
  • Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. 
  • Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process. 
  • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 
  • Wild-type p53: tumors can't stand it. 
  • c-Jun promotes whereas JunB inhibits epidermal neoplasia. 
  • c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. 
  • hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblasts.