Scholars@Duke
Alexis LaRosa

Scholarly Works

SCIFER: approach for analysis of LINE-1 mRNA expression in single cells at a single locus resolution.

Journal article Mobile DNA · August 2022 BackgroundEndogenous expression of L1 mRNA is the first step in an L1-initiated mutagenesis event. However, the contribution of individual cell types to patterns of organ-specific L1 mRNA expression remains poorly understood, especially at single- ... Full text Cite

Organ-, sex- and age-dependent patterns of endogenous L1 mRNA expression at a single locus resolution.

Journal article Nucleic acids research · June 2021 Expression of L1 mRNA, the first step in the L1 copy-and-paste amplification cycle, is a prerequisite for L1-associated genomic instability. We used a reported stringent bioinformatics method to parse L1 mRNA transcripts and measure the level of L1 mRNA ex ... Full text Cite