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Anna Giczewska

Biostatistician III
Duke Clinical Research Institute
Box 3850, Durham, NC 27715
6034 Epping Forest Drive, Raleigh, NC 27613

Scholarly Works


Heart Failure With Preserved Ejection Fraction Across the Spectrum of Body Mass Index: Hemodynamic and Echocardiographic Characteristics and Outcomes.

Journal article JACC Heart Fail · March 2026 BACKGROUND: Limited data are available on the relationship between body mass index (BMI) and heart failure (HF) physiology or clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF). OBJECTIVES: This study aims to assess t ... Full text Link to item Cite

Functional and Prognostic Implications of Different Iron Deficiency Definitions in Heart Failure: Insights From HEART-FID.

Journal article JACC Heart Fail · December 2025 BACKGROUND: Iron deficiency (ID) is common in patients with heart failure (HF), but optimal use of circulating iron indices as diagnostic criteria and for defining treatment targets remain uncertain. OBJECTIVES: This study sought how to determine how indiv ... Full text Link to item Cite

Comparison of adverse events, prescription medication, and costs after hip, knee, and shoulder total joint arthroplasty: a retrospective cohort study.

Journal article Arthroplasty · May 6, 2025 BACKGROUND: Outcomes from Total Joint Arthroplasty (TJA) are variable but generally favorable. However, the literature is lacking regarding direct comparisons of important outcomes across TJA sites. Such comparisons are of paramount importance to informing ... Full text Link to item Cite

Machine Learning Computer Vision Point of Care Decision Support of Echocardiographic Identification of Hypertrophic Cardiomyopathy.

Conference JACC Adv · May 2025 BACKGROUND: Hypertrophic cardiomyopathy (HCM) remains underdiagnosed, and artificial intelligence tools for echocardiographic recognition have been hampered by lack of insight into drivers of model predictions and ease of implementation. OBJECTIVES: The pu ... Full text Link to item Cite

Are the cardiovascular properties of GLP-1 receptor agonists differentially modulated by sulfonylureas? Insights from post-hoc analysis of EXSCEL.

Journal article Diabetes Res Clin Pract · June 2024 AIMS: To examine whether the cardiovascular effects of glucagon-like peptide-1 (GLP-1) receptor agonists are attenuated by concurrent sulfonylurea (SU) therapy in a post-hoc analysis of the Exenatide Study of Cardiovascular Event Lowering (EXSCEL). METHODS ... Full text Link to item Cite

Long-term outcomes of phenoclusters in severe tricuspid regurgitation.

Journal article Eur Heart J · June 1, 2023 AIMS: Severe tricuspid regurgitation (TR) exhibits high 1-year morbidity and mortality, yet long-term cardiovascular risk overall and by subgroups remains unknown. This study characterizes 5-year outcomes and identifies distinct clinical risk profiles of s ... Full text Link to item Cite

Electrocardiographic parameters associated with pacemaker induced cardiomyopathy.

Journal article J Electrocardiol · 2023 BACKGROUND: Chronic right ventricular (RV) pacing can induce left ventricular (LV) dyssynchrony and cause pacemaker induced cardiomyopathy (PiCM). Identifying which patients are at risk for PiCM is limited. METHODS: Patients receiving RV-only permanent pac ... Full text Link to item Cite

Effect of race on cardiometabolic responses to once-weekly exenatide: insights from the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).

Journal article Cardiovasc Diabetol · June 27, 2022 BACKGROUND: To determine whether there were racial differences in short-term cardiometabolic responses to once-weekly exenatide (EQW) in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL). METHODS: EXSCEL enrolled 14,752 patients with type 2 dia ... Full text Link to item Cite

Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial.

Journal article Circulation · March 15, 2022 BACKGROUND: Observational data suggest that catheter ablation may be safe and effective to treat younger and older patients with atrial fibrillation. No large, randomized trial has examined this issue. This report describes outcomes according to age at ent ... Full text Open Access Link to item Cite

Effect of once-weekly exenatide on hospitalization for acute coronary syndrome or coronary revascularization in patients with type 2 diabetes mellitus.

Journal article Am Heart J · September 2021 Cardiovascular (CV) outcome studies of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shifted the paradigm of type 2 diabetes management given their benefits regarding a reduction in major adverse CV events. However, the relationship between GL ... Full text Link to item Cite

Predicting Recurrent Care Seeking of Physical Therapy for Musculoskeletal Pain Conditions.

Journal article Pain Med · August 6, 2021 OBJECTIVE: Musculoskeletal pain conditions are a leading cause of pain and disability internationally and a common reason to seek health care. Accurate prediction of recurrence of health care seeking due to musculoskeletal conditions could allow for better ... Full text Link to item Cite

Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights From the VICTORIA Trial.

Journal article JAMA Cardiol · June 1, 2021 IMPORTANCE: The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH. OBJECTIVE: To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified i ... Full text Link to item Cite

Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure.

Journal article Journal of physiology and biochemistry · May 2021 Redox balance and methylation are crucial to homeostasis and are linked by the methionine-homocysteine cycle. We examined whether differences in methylation potential, measured as plasma levels of S-adenosyl methionine (SAM) and S-adenosyl homocysteine (SA ... Full text Cite

Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy: Results From the CABANA Trial.

Journal article Circulation · February 16, 2021 BACKGROUND: Among patients with atrial fibrillation (AF), women are less likely to receive catheter ablation and may have more complications and less durable results. Most information about sex-specific differences after ablation comes from observational d ... Full text Open Access Link to item Cite

Prevalence and predictors of no-shows to physical therapy for musculoskeletal conditions.

Journal article PLoS One · 2021 OBJECTIVES: Chronic pain affects 50 million Americans and is often treated with non-pharmacologic approaches like physical therapy. Developing a no-show prediction model for individuals seeking physical therapy care for musculoskeletal conditions has sever ... Full text Open Access Link to item Cite

Ultrafiltration in Acute Heart Failure: Implications of Ejection Fraction and Early Response to Treatment From CARRESS-HF.

Journal article J Am Heart Assoc · December 15, 2020 Background Ultrafiltration is not commonly used because of higher incidence of worsening renal function without improved decongestion. We examined differential outcomes of high versus low fluid removal and preserved versus reduced ejection fraction (EF) in ... Full text Open Access Link to item Cite

Reply: Specifics of Dose Modification in ARISTOTLE.

Journal article J Am Coll Cardiol · July 7, 2020 Full text Link to item Cite

Clinical and Pharmacological Effects of Apixaban Dose Adjustment in the ARISTOTLE Trial.

Journal article J Am Coll Cardiol · March 17, 2020 BACKGROUND: In the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial, patients with atrial fibrillation and ≥2 dose-adjustment criteria (age ≥80 years, weight ≤60 kg, or creatinine ≥1.5 mg/dl [133 μmo ... Full text Link to item Cite

Spironolactone in Acute Heart Failure Patients With Renal Dysfunction and Risk Factors for Diuretic Resistance: From the ATHENA-HF Trial.

Journal article Can J Cardiol · September 2019 BACKGROUND: Acute heart failure (HF) patients with renal insufficiency and risk factors for diuretic resistance may be most likely to derive incremental improvement in congestion with the addition of spironolactone. METHODS: The Aldosterone Targeted Neuroh ... Full text Link to item Cite

Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: Insights from the ARISTOTLE trial.

Journal article Clin Cardiol · May 2019 BACKGROUND: The optimal anticoagulation strategy for patients with atrial fibrillation (AF) and bioprosthetic valve (BPV) replacement or native valve repair remains uncertain. HYPOTHESIS: We evaluated the safety and efficacy of apixaban vs warfarin in pati ... Full text Link to item Cite

An assessment of health status and health behaviours in adolescents: main points and methods of the SOPKARD-Junior programme

Journal article Archives of Medical Science · January 1, 2018 Introduction: The study involved preparing and implementation a model of complex screening programme for adolescents and comparison of anthropometric examinations between the population of the SOPKARD-Junior programme and representative sample of Polish ch ... Full text Cite

Using wearable device for biomedical signal acquisition and processing

Conference Proceedings 2017 10th International Conference on Human System Interactions Hsi 2017 · August 8, 2017 In this paper we present the research conducted on synchronous measurements of biosignals. The experiment was conducted to evaluate the possibility of estimating vital signs based on eye tracking. Method: The eGlasses platform was used for acquisition of E ... Full text Cite