Annee Nguyen

Journal article Neurooncol Adv · May 2026 Vertebral metastatic disease results from many types of cancer and can have a devastating impact on patient mobility, psychological health, quality of life, and ultimately overall patient survival. However, the development of radiotherapy and surgical tech ... Full text Link to item Cite

Intraoperative brain tumor classification via laser-induced fluorescence spectroscopy and machine learning.

Journal article J Neurosurg · August 1, 2025 OBJECTIVE: To optimize neurosurgical tumor resection, tissue types and borders must be appropriately identified. Authors of this study established the use of a nondestructive laser-based endogenous fluorescence spectroscopy device, "TumorID," to almost imm ... Full text Open Access Link to item Cite

Validation of the graded prognostic assessment and recursive partitioning analysis as prognostic tools using a modern cohort of patients with brain metastases.

Journal article Neurooncol Pract · December 2024 BACKGROUND: Prognostic indices for patients with brain metastases (BM) are needed to individualize treatment and stratify clinical trials. Two frequently used tools to estimate survival in patients with BM are the recursive partitioning analysis (RPA) and ... Full text Open Access Link to item Cite

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers.

Journal article bioRxiv · March 21, 2024 Survival for metastatic breast cancer is low and thus, continued efforts to treat and prevent metastatic progression are critical. Estrogen is shown to promote aggressive phenotypes in multiple cancer models irrespective of estrogen receptor (ER) status. S ... Full text Link to item Cite

Single-cell RNA sequencing comparison of the human metastatic prostate spine tumor microenvironment.

Journal article STAR Protoc · March 15, 2024 Spinal column tumors can be difficult to process for single-cell omic studies, given the heterogeneity in tissue. Here, we present a protocol for operating room-to-benchtop single-cell processing of clinical specimens from a prostate cancer patient. We des ... Full text Open Access Link to item Cite

A blinded study using laser induced endogenous fluorescence spectroscopy to differentiate ex vivo spine tumor, healthy muscle, and healthy bone.

Journal article Sci Rep · January 22, 2024 Ten patients undergoing surgical resection for spinal tumors were selected. Samples of tumor, muscle, and bone were resected, de-identified by the treating surgeon, and then scanned with the TumorID technology ex vivo. This study investigates whether Tumor ... Full text Open Access Link to item Cite

UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.

Journal article Oncotarget · September 28, 2023 UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, ... Full text Open Access Link to item Cite

Using Corneal Confocal Microscopy to Identify Therapeutic Agents for Diabetic Neuropathy.

Journal article Journal of clinical medicine · April 2022 Corneal confocal microscopy (CCM) is emerging as a tool for identifying small fiber neuropathy in both peripheral neuropathies and neurodegenerative disease of the central nervous system (CNS). The value of corneal nerves as biomarkers for efficacy of clin ... Full text Cite

Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression.

Journal article World Neurosurg · November 2021 Epidural spinal cord compression (ESCC) secondary to spine metastases is one of the most devastating sequelae of primary cancer as it may lead to muscle weakness, paresthesia, pain, and paralysis. Spine metastases occur through a multistep process that can ... Full text Link to item Cite

Generation of a Biobank From Two Adult Thoroughbred Stallions for the Functional Annotation of Animal Genomes Initiative.

Journal article Frontiers in genetics · January 2021 Following the successful creation of a biobank from two adult Thoroughbred mares, this study aimed to recapitulate sample collection in two adult Thoroughbred stallions as part of the Functional Annotation of the Animal Genome (FAANG) initiative. Both stal ... Full text Open Access Cite

Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes.

Journal article Molecular metabolism · February 2019 ObjectiveDiabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitocho ... Full text Open Access Cite