Overview
Synthetic Virology & Gene Therapy
Current Appointments & Affiliations
Professor in Surgery
·
2019 - Present
Surgery, Surgical Sciences,
Surgery
Director of Gene Therapy
·
2018 - Present
Surgery, Surgical Sciences,
Surgery
Professor of Molecular Genetics and Microbiology
·
2019 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Professor of Biomedical Engineering
·
2019 - Present
Biomedical Engineering,
Pratt School of Engineering
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Efficient kidney gene transfer and proximal tubule transduction using self-complementary AAV.cc47 vectors.
Journal Article Mol Ther Methods Clin Dev · December 11, 2025 Gene delivery to critical cell types within the kidney can enable preclinical evaluation of gene therapies for kidney disease. The novel adeno-associated virus AAV.cc47 was discovered after sequential evolution in mice, pigs, and macaques and improved tran ... Full text Link to item CiteLiver-directed AAV gene therapy in mice corrects glycogen storage disease type IX γ2.
Journal Article Sci Adv · November 14, 2025 Glycogen storage disease (GSD) type IX γ2 is a rare inborn error of metabolism where a defect in glycogenolysis leads to the inability to break down glycogen in the liver. Patients with GSD IX γ2 develop hypoglycemia and advanced liver disease, placing the ... Full text Link to item CiteA Novel IgG- and IgM-Cleaving Endopeptidase, IceMG, for Antibody-Mediated Rejection.
Journal Article Am J Transplant · October 22, 2025 Antibody-mediated rejection (AMR) remains a significant barrier to successful outcomes in both allo- and xenotransplantation. In this study, we investigate the efficacy of a novel recombinant endopeptidase, IceMG, which simultaneously cleaves IgG and IgM i ... Full text Link to item CiteRecent Grants
Interdisciplinary Research Training Program in AIDS
Inst. Training Prgm or CMEAdvisor · Awarded by National Institutes of Health · 2010 - 2030Kidney targeted AAV for gene therapy
ResearchPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2025 - 2030Immunomodulation in AAV gene therapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2029View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
2004
Ph.D.