Xuhui Bao
Adjunct Assistant Professor in the Department of Pathology

Cancer is a major public health problem all over the world and is the second leading cause of death in the United States. Although the standard of care including surgery, chemotherapy, and radiotherapy has advanced over the years, the overall outcome of cancer patients is still dismal. In the recent decade, novel targeted therapies, combinational therapies, and immunotherapies have emerged as powerful weapons for cancer treatment, which have been shifting the paradigm of clinical guidelines. However, despite their success in achieving the long-term survival of 10-30% of treated individuals, novel immunotherapies are still ineffective for most cancer patients. Therefore, it is urgent and of tremendous interest to develop more precision anti-tumor strategies by discovering novel antitumor targets, understanding the mechanisms of resistance to immunotherapies and the complexity of tumor microenvironment, as well as exploring innovative therapeutic options in the future. My current research focuses on below two dimensions of cancer research, especially in the field of cancer immunological research: (1)The clinic-based discovery of novel antitumor targets and their relationships to those key carcinogenesis-related pathways and tumor immune microenvironment, using state-of-the-art omics data mining tools, CRISPR-Cas9 related gene editing technologies, and high-throughput screening methods; (2)The clinic-oriented development of novel antitumor strategies based on the above discoveries, to be initially validated at the preclinical level both in vitro and in vivo, and ultimately translated into clinical trials in the late stage.

 

Current Appointments & Affiliations

Contact Information

  • Duke Box 3712, Durham, NC 27710
  • Duke Box 3712, Durham, NC 27710

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