Scholars@Duke
Billy Y Lan

Billy Y Lan

Assistant Professor of Surgery
Surgery, Colorectal Surgery

Scholarly Works - Journal articles

Circulating Tumor DNA as a Novel Prognostic Biomarker of Therapeutic Efficacy in Patients with Unresectable Colorectal Liver Metastases Treated with Hepatic Arterial Infusion.

Journal article Ann Surg Oncol · October 2025 BACKGROUND: Hepatic arterial infusion (HAI) chemotherapy is an expanding treatment for patients with unresectable colorectal liver metastases (uCRLM). This study examined circulating tumor DNA (ctDNA) as a novel biomarker to prognosticate oncologic outcome ... Full text Link to item Cite

Single-Center Experience with Magnetic Retraction in Colorectal Surgery.

Journal article J Laparoendosc Adv Surg Tech A · August 2019 Background: Appropriate tissue retraction is essential in laparoscopic surgery, and colorectal operations often require an additional incision and trocar that can disturb visualization and maneuverability. Each incision carries an increased risk for compli ... Full text Link to item Cite

Factors affecting the surgical approach and timing of bilateral adrenalectomy.

Journal article Surg Endosc · July 2015 BACKGROUND: Laparoscopic adrenalectomy has gained widespread acceptance. However, the optimal surgical approach to laparoscopic bilateral adrenalectomy has not been clearly defined. The aim of this study is to analyze the patient and intraoperative factors ... Full text Link to item Cite

Positron emission tomography in hepatobiliary and pancreatic malignancies: a review.

Journal article American journal of surgery · August 2012 BackgroundThe prognosis for hepatobiliary and pancreatic malignancies is dismal. Surgery remains the primary curative option, but unresectable disease is often discovered during operative exploration. Positron emission tomography (PET) provides un ... Full text Cite

KIR genotypic diversity can track ancestries in heterogeneous populations: a potential confounder for disease association studies.

Journal article Immunogenetics · February 2012 Killer cell immunoglobulin-like receptors (KIR) are encoded by highly polymorphic genes that regulate the activation of natural killer (NK) cells and other lymphocyte subsets and likely play key roles in innate and adaptive immunity. Association studies in ... Full text Link to item Cite

Long-term histological effects of preemptive antiviral therapy in liver transplant recipients with hepatitis C virus infection.

Journal article Liver Transpl · October 2008 The long-term effects of preemptive antiviral therapy on fibrosis progression in liver transplant recipients with hepatitis C virus (HCV) were examined in a cohort of consecutive liver transplant recipients who received preemptive antiviral therapy for 48 ... Full text Link to item Cite

Ascites in hepatitis C liver transplant recipients frequently occurs in the absence of advanced fibrosis.

Journal article Am J Transplant · February 2008 Ascites after liver transplantation is uncommon (3-7%) but causes morbidity and mortality. Although hepatitis C (HCV), pretransplant ascites, encephalopathy and cold ischemia time have been identified as predictors, neither posttransplant renal function no ... Full text Link to item Cite

Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy.

Journal article Hepatology · February 2007 UNLABELLED: Recent studies have suggested that beta-catenin is involved in the regulation of hepatocyte proliferation in multiple contexts, including organ development and tumorigenesis. We explored the role of beta-catenin during liver regeneration using ... Full text Link to item Cite

Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.

Journal article Hepatology · April 2006 There is accumulating evidence that Wnt/beta-catenin signaling is involved in the regulation of liver development and physiology. The presence of genetic alterations resulting in constitutive beta-catenin stabilization in human and murine liver tumors also ... Full text Link to item Cite