Scholars@Duke
Brian C. Mac Grory

Brian C. Mac Grory

Associate Professor of Neurology
Neurology, Stroke and Vascular Neurology
40 Duke Medicine Circle, Durham, NC 27708
Office hours 9AM-6PM Monday-Friday  

Scholarly Works - Conferences

Abstract A146: Antiplatelet Therapy Combinations and Outcomes after Spontaneous Intracerebral Hemorrhage in the AHA Get With The Guidelines Registry

Conference Stroke · February 2026 Introduction: Prior studies evaluating the relationship between antiplatelet therapy (APT) and outcomes after spontaneous intracerebral hemorrhage (ICH) have grouped all antiplatelet a ... Full text Cite

Abstract WP121: Pregnancy-Associated Cervical Artery Dissection: STOP-CAD Analysis

Conference Stroke · February 2026 Background and Objectives: Pregnancy and the postpartum period increase the risk of cervical artery dissection (CEAD), a notable cause of stroke in young women. We aimed to describe th ... Full text Cite

Abstract WP127: Sex-Specific Differences in Presentation and Outcomes after Cervical Artery Dissection

Conference Stroke · February 2026 Background and Objectives: Cervical artery dissection (CeAD) is a leading cause of ischemic stroke in younger adults, yet sex-specific variations in its clinical presentation, imaging ... Full text Cite

Abstract A098: Timeliness of Emergency Care for Intracerebral Hemorrhage Compared to Ischemic Stroke from 2015 to 2024: Insights from Get With the Guidelines-Stroke

Conference Stroke · February 2026 Introduction: There is minimal real-world data on whether stroke process quality metrics differ for intracerebral hemorrhage (ICH) and acute ischemic stroke (AIS) and if they have chan ... Full text Cite

Abstract A048: De Novo Pseudoaneurysm Formation After Cervical Artery Dissection: Incidence, Risk Factors, and Outcomes

Conference Stroke · February 2026 Background: The clinical characteristics and complications associated with de novo pseudoaneurysm formation beyond the acute phase of cervical artery dissection remain poorly defined. ... Full text Cite

Abstract DP181: Lower frequency of ischemic stroke and better functional outcome in patients with spontaneous cervical artery dissection and history of migraine: secondary analysis of the STOP-CAD study

Conference Stroke · February 2026 Introduction: Migraine has been reported to be associated with an increased risk of spontaneous cervical artery dissection (sCeAD), a leading cause of ischemic stroke, particularly in ... Full text Cite

Abstract A132: Young Adults with Cervical Artery Dissection have a Distinct Clinical Phenotype: A Post-Hoc Analysis of the STOP-CAD Study

Conference Stroke · February 2026 Background and Objectives: Cervical artery dissection (CeAD) is a common cause of ischemic stroke in young adults. We aim to identify age-based differences in clinical presentation, im ... Full text Cite

Abstract A145: Pre-Hospital Time Matters: Impact of Prehospital Delays on Receipt of IV Thrombolysis and Endovascular Therapy in the Get With The Guidelines-Stroke Registry

Conference Stroke · February 2026 Background: Timely prehospital care is the first link in the stroke chain of survival, yet large-scale data on how specific EMS intervals affect acute stroke treatment are limited. We ... Full text Cite

Abstract 4370283: Real-World Effectiveness of GLP-1 Receptor Agonists on Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF).

Conference Circulation · November 4, 2025 Introduction/Background: Multiple clinical trials have demonstrated that glucagon-like peptide 1 receptor agonists (GLP-1 Ras) improve symptoms, physical function, and potentially redu ... Full text Cite

Abstract 4367284: Hospital Admissions With Hypertensive Emergency Increased While Admissions With Asymptomatic Elevated Inpatient Blood Pressure Decreased From 2014-2024: A Nationwide Study

Conference Circulation · November 4, 2025 Introduction: Hypertension is common in acute care settings, and there is controversy on the best management depending on severity of elevation and the presence of end-organ damage, as ... Full text Cite

Abstract 4367419: Glucagon-Like Peptide-1 Receptor Agonist Use Is Associated With Lower Risk Of Cardiovascular Event Recurrence Compared With Use Of Bupropion-Naltrexone or Phentermine-Topiramate: A Nationwide Target Trial Emulation Study

Conference Circulation · November 4, 2025 Introduction: The Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT) trial showed that the glucagon-like peptide-1 receptor agonist (GLP1-RA) semaglutide was ... Full text Cite

Abstract 4367381: Among Older Adults With Atrial Fibrillation, First Anticoagulant Prescription Is Not Associated with Reduced Hazard of Ischemic Stroke but Is Associated with Increased Hazard of Major Bleeding: A Nationwide Study

Conference Circulation · November 4, 2025 Introduction: Sevferal trials have demonstrated that oral anticoagulation reduces ischemic stroke risk in patients with atrial fibrillation (AF), the most common cardiac arrythmia amon ... Full text Cite

Abstract 4363087: Calcitonin Gene-Related Peptide (CGRP) Inhibitor Use Is Associated With Increased Cardiovascular Event Risk in Patients with Migraine: A Nationwide Study

Conference Circulation · November 4, 2025 Introduction: Calcitonin gene-related peptide (CGRP) inhibitors are increasingly used in the United States (US) for the prevention and treatment of migraine, but population-based data ... Full text Cite

Abstract 4367343: Transgender Male and Gender Non-Binary/Genderqueer Patients are Less Likely to Receive Guideline-Indicated Cardiovascular Care than Cisgender Patients: A Nationwide Study

Conference Circulation · November 4, 2025 Introduction: People identifying as transgender, non-binary, or genderqueer are at higher risk for cardiovascular disease. Additionally, bias and overt discrimination limit care access ... Full text Cite

Abstract 4145944: Disparities in Cardiovascular Multimorbidity and Mortality among Dual Medicare-Medicaid Beneficiaries: A Nationwide Cohort Study of >2 Million Patients

Conference Circulation · November 12, 2024 Introduction/Background: Patients dually eligible for Medicare and Medicaid have higher mortality rates and disparate outcomes for acute cardiovascular conditions. However, the association between dua ... Full text Cite

Abstract 4145883: Elevated International Normalized Ratio Is Associated with Severity of Intracerebral Hemorrhage for Patients Taking Direct Oral Anticoagulants

Conference Circulation · November 12, 2024 Introduction/Background: While the international normalized ratio (INR), a marker of functioning of the extrinsic and final common pathways of the coagulation cascade is associated with increased intr ... Full text Cite

IV Thrombolysis for central retinal artery occlusion – Real-world experience from a comprehensive stroke center

Conference Journal of Stroke and Cerebrovascular Diseases · April 1, 2024 Objectives: Central retinal artery occlusion (CRAO) is a stroke of the retina potentially amenable to intravenous thrombolysis (IVT). We aimed to determine feasibility of an emergency treatment protocol and risk profile of IVT for CRAO in a comprehensive s ... Full text Cite

Abstract 43: Race-Ethnic Specific Trends in Stroke Thrombolysis Care Metrics in Relation to U.S. Target: Stroke Nationwide Quality Improvement Program 2003-2021

Conference Stroke · February 2024 Objectives: To examine whether thrombolysis care metrics have improved in all races and ethnicities with the launch and advance of Target: Stroke (TS) national quality initiatives. ... Full text Cite

Abstract 24: Differences in Door to Needle and Door In Door Out Times for Tenecteplase vs Alteplase in Acute Ischemic Stroke: Findings From Get With the Guidelines Stroke

Conference Stroke · February 2024 Introduction: Tenecteplase (TNK) has arisen as an alternative to alteplase (ALT) for emergent treatment of acute ischemic stroke. Shorter times to prepare and administer TNK raises the possibility tha ... Full text Cite

Abstract WP252: MARS: Migraine and Retinal Stroke - A Population-Based Cohort Study of 39 Million Patients

Conference Stroke · February 2024 Introduction: Migraine is a risk factor for cerebral ischemic stroke. However, it is not known if migraine is a risk factor for retinal stroke (central retinal artery occlusion, CRAO). Full text Cite

Abstract 30: Association Between Hospital-ascertained Atrial Fibrillation And Central Retinal Artery Occlusion: A Study Of 12 Million Patients

Conference Stroke · February 2023 Introduction: Atrial fibrillation (AF) is a major risk factor for cerebral ischemic stroke. However, it is not known whether AF predicts the development of central retinal artery occlusion (CRAO), a f ... Full text Cite

Abstract WP158: Impact Of Atrial Fibrillation On Clinical Outcomes After Endovascular Thrombectomy: A Post-Hoc Analysis Of The Defuse-3 Trial

Conference Stroke · February 2023 Introduction: Previous studies have failed to show an interaction between known atrial fibrillation (AF) and treatment effect of endovascular thrombectomy (EVT) performed within 6 hours of time last k ... Full text Cite

Abstract TP116: Procoagulant Reversal Of Warfarin After Intracranial Hemorrhage Is Not Associated With Improved Functional Outcome When Coagulation Is Abnormal Without Full Anticoagulation

Conference Stroke · February 2023 Introduction: Although the current guidelines recommend procoagulant reversal of elevated INR >= 2.0 (International Normalized Ratio) in patients with intracranial hemorrhage using warfarin, the be ... Full text Cite

Abstract 67: Endovascular Thrombectomy In Patients With Acute Ischemic Stroke And Recent Use Of Oral Vitamin K-Antagonists: The Get With The Guidelines-Stroke Program

Conference Stroke · February 2023 Introduction: Emergent endovascular thrombectomy (EVT) is effective in improving outcomes in patients with stroke caused by large vessel occlusion. However, there are limited data on the use of EVT in ... Full text Cite

Abstract 78: Neighborhood Socioeconomic Deprivation Is Associated With Increased 30-day Mortality After Stroke: Results From A Nationwide Study Of 755,899 Medicare Patients

Conference Stroke · February 2023 Introduction: The relationship between neighborhood socioeconomic deprivation- a reflection of the general economic and environmental conditions of a neighborhood- and outcomes after stroke is not kno ... Full text Cite

Abstract 25: Safety And Outcomes Of Endovascular Thrombectomy In Acute Ischemic Stroke Patients With Recent Use Of Non-vitamin K Antagonist Oral Anticoagulants

Conference Stroke · February 2023 Introduction: An increasing number of patients with acute ischemic stroke (AIS) have recently used non-vitamin K antagonist oral anticoagulants (NOACs). However, there are limited data on safety of en ... Full text Cite

Abstract WMP1: Complications Of Intravenous Tenecteplase For The Treatment Of Acute Ischemic Stroke: A Systematic Review And Meta-Analysis

Conference Stroke · February 2023 Introduction: Prior systematic reviews have focused on a comparison of efficacy endpoints between tenecteplase (TNK) and alteplase. The objectives of this study are to determine whether the rate of tr ... Full text Cite

Abstract TP96: Mild Luminal Stenosis Of Parent Artery And Neurologic Deterioration After Acute Lacunar Stroke

Conference Stroke · February 2022 Introduction: Neurologic deterioration (ND) occurs in a quarter of acute lacunar infarcts and may lead to severe disability, but underlying pathophysiology of ND remains poorly understood. We sought t ... Full text Cite

Abstract 116: Unmet Need In Acute Ischemic Stroke Patients Not Treated With Alteplase

Conference Stroke · February 2022 Introduction: Early administration of intravenous tissue plasminogen activator (IV alteplase) improves functional outcomes in patients with acute ischemic stroke (AIS), yet many patients are not treat ... Full text Cite

Abstract 35: Unmet Need In Acute Ischemic Stroke Patients Arriving After 4.5 Hours

Conference Stroke · February 2022 Introduction: Many patients arrive beyond the guideline-recommended time window for treatment with IV alteplase. For most of these patients, few treatment options exist. There is a need to understand ... Full text Cite

Abstract TMP77: Borderzone Infarction Predicts Recurrence In Patients With Intracranial Atherosclerosis: A Meta-analysis

Conference Stroke · February 2022 Background: Patients with symptomatic intracranial stenosis (ICAS) face elevated risks of recurrent cerebrovascular events (RCE) despite optimal medical therapy. Borderzone infarcts (BZI) indirectly c ... Full text Cite

Abstract 159: Recurrent Ischemic Stroke And Cigarette Smoking: A Secondary Analysis Of The POINT Trial

Conference Stroke · February 2022 Background: Recent data suggest that in patients with acute myocardial infarction (MI), the effect of clopidogrel on risk reduction of cardiovascular outcomes is more pronounced in smokers. The aim of ... Full text Cite

Abstract TMP74: Direct Oral Anticoagulants Vs. Vitamin K Antagonists In Patients With Cerebral Venous Thrombosis: A Systematic Review And Meta-analysis

Conference Stroke · February 2022 Introduction: Direct oral anticoagulants (DOACs) have emerged as a potential anticoagulant therapy for patients with cerebral venous thrombosis (CVT). We conducted a systematic review and meta-analysi ... Full text Cite

Abstract TP227: High Disability Rates In Young Patients With PFO Attributable Cryptogenic Ischemic Strokes

Conference Stroke · February 2022 Introduction: Approximately 30% of ischemic strokes are cryptogenic and 40-50% of these patients have a patent foramen ovale (PFO) detected during work up. While the risk of ischemic stroke attributed ... Full text Cite

Abstract 155: Hyperglycemia And Hypertension Predict Subsequent Ischemic Stroke In Patients With Minor Stroke Or TIA Treated With Dual Antiplatelet Therapy: A Post-hoc Analysis Of The POINT Trial

Conference Stroke · February 2022 Background: Randomized trials have shown that dual antiplatelet therapy (DAPT) reduces the risk of subsequent ischemic stroke in patients with minor stroke or high-risk TIA (MS-TIA). However, the 90 d ... Full text Cite

Abstract P180: Protocolized Selection for Telestroke Activation in The Extended Window for Thrombectomy

Conference Stroke · March 2021 Background: The advent of biomarker-driven identification of candidates for acute therapies in the 4.5-24-hour time window has resulted in an increase in the number of telestroke consults with low yie ... Full text Cite

Abstract P661: Atheromatous Disease of the Parent Artery is Common in Patients With Lacunar Infarcts

Conference Stroke · March 2021 Background: Perforator disease caused by parent artery atheromatous disease is one of the mechanisms implicated in the pathogenesis of lacunar infarcts, but there is limited data on its prevalence. We ... Full text Cite

Abstract P674: Markers of Atherosclerotic Disease but Not Small Vessel Disease Predict Neurologic Deterioration in Acute Lacunar Strokes

Conference Stroke · March 2021 Introduction: Neurologic deterioration (ND) occurs in a quarter of acute lacunar infarct patients and may lead to severe disability. The underlying pathophysiology of ND in these patients is not clear ... Full text Cite

Abstract P592: Admission Hyperglycemia is Associated With Subsequent Ischemic Stroke After Transient Ischemic Attack or Minor Stroke: A Secondary Analysis of the POINT Trial

Conference Stroke · March 2021 Introduction: Hyperglycemia is associated with increased lesion volume and worse functional outcome after acute ischemic stroke, however, it is not known whether it is associated with further cerebrov ... Full text Cite

Abstract P254: Decompressive Hemicraniectomy and Functional Outcomes After Malignant Cerebral Infarction: Real World Experience From a Comprehensive Stroke Center

Conference Stroke · March 2021 Background: Decompressive hemicraniectomy (DHC), performed in select patients with malignant infarction (MCI), reduces mortality. However, there is conflicting evidence surrounding the use of DHC in i ... Full text Cite

Abstract MP46: Internal Carotid Artery Web and Acute Ischemic Stroke - A Systematic Review and Meta-Analysis

Conference Stroke · March 2021 Introduction: The carotid web is a compelling potential mechanism of embolic ischemic stroke. In this study, we perform a systematic review and meta-analysis to determine the prevalence of ipsilesiona ... Full text Cite

Abstract P387: Stroke Despite Anticoagulation Therapy Predicts Early Recurrence After Cardioembolic Stroke: The IAC-Study

Conference Stroke · March 2021 Background and purpose: A proportion of patients with ischemic stroke and atrial fibrillation (AF) have an ischemic stroke despite being prescribed anticoagulation therapy. In this study of patients w ... Full text Cite

Abstract P12: Alteplase Reduces Mortality in Patients With Ischemic Stroke and Atrial Fibrillation: Analysis of the IAC Study

Conference Stroke · March 2021 Background and Purpose: Multiple studies have established that intravenous thrombolysis with alteplase improves outcome after acute ischemic stroke. However, assessment of thrombolysis’ efficacy in st ... Full text Cite

Abstract P10: Posterior Circulation Strokes Are Less Likely to Receive Alteplase or Mechanical Thrombectomy: Analysis From the IAC Study

Conference Stroke · March 2021 Background: Emergent treatment with intravenous thrombolysis and mechanical thrombectomy improved outcomes in patients with acute ischemic stroke. We aim to identify differences in acute stroke treatm ... Full text Cite

Abstract P100: Hemorrhagic Stroke in the Setting of COVID-19 is Associated With Anticoagulation Use

Conference Stroke · March 2021 Introduction: While the thrombotic complications of COVID-19 have been described, there are limited data on its implications in hemorrhagic stroke. The clinical characteristics, underlying stroke mech ... Full text Cite

Abstract P677: Ischemic Stroke, Depressed Ejection Fraction, and Sinus Rhythm: Prevalence, Practice Patterns, and Outcomes

Conference Stroke · March 2021 Introduction: After WARCEF, there is limited data about the epidemiology and treatment strategies for patients after an acute ischemic stroke (AIS) with existing or new left ventricular cardiomyopathy ... Full text Cite

Abstract P649: Extracranial Hemorrhage in the Setting of Gastrointestinal Or Genitourinary Cancer is Associated With Increased Risk of Ischemic Stroke in Patients With Atrial Fibrillation

Conference Stroke · March 2021 Background and Purpose: Anticoagulation therapy reduces the risk for ischemic stroke in atrial fibrillation (AF) but also predisposes patients to hemorrhagic complications. Patients with GI or GU canc ... Full text Cite

Abstract 59: Presence of Infarct Predicts Recurrence and Efficacy of Dual Antiplatelet Therapy: A Post-Hoc Analysis of the POINT Trial

Conference Stroke · March 2021 Background: The combination of aspirin and clopidogrel for 90 days after minor stroke or transient ischemic attack (TIA) reduced the risk of recurrent stroke in the POINT trial. The risk reduction was ... Full text Cite

Abstract P27: Safety and Efficacy of Alteplase in Ischemic Stroke Patients > 80 Years of Age in the Extended Time Window

Conference Stroke · March 2021 Background: While patients > 80 years of age were originally excluded from the ECASS 3 trial showing benefit in the 3 – 4.5-hour window, recent studies have shown that intravenous alteplase is safe ... Full text Cite

Abstract P438: A Reassessment of Hemoglobin and Hematoma Expansion in Intracerebral Hemorrhage

Conference Stroke · March 2021 Background: Prior studies identified an increased risk of hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (ICH) and lower admission hemoglobin (Hgb) levels. We aimed to e ... Full text Cite

Abstract 31: Penumbra Consumption Rates Based on T Max Delay and Reperfusion Status: A Post-Hoc Analysis of the Defuse-3 Trial

Conference Stroke · March 2021 Introduction: In patients with acute large vessel occlusion, the definition of penumbral tissue based on T max delay perfusion imaging is not well established in relation to late-window endovascular t ... Full text Cite