Brittany Elliott

Journal article Front Oncol · 2023 While many factors have been implicated in breast cancer progression, effective treatments are still lacking. In recent years, it has become clear that posttranscriptional regulation plays a key role in the aberrant gene expression underlying malignancy an ... Full text Open Access Link to item Cite

Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression.

Journal article Cell Host Microbe · August 14, 2019 How the covalent modification of mRNA ribonucleotides, termed epitranscriptomic modifications, alters mRNA function remains unclear. One issue has been the difficulty of quantifying these modifications. Using purified HIV-1 genomic RNA, we show that this R ... Full text Link to item Cite

Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo.

Journal article Nat Commun · July 30, 2019 Epitranscriptomic modifications of mRNA are important regulators of gene expression. While internal 2'-O-methylation (Nm) has been discovered on mRNA, questions remain about its origin and function in cells and organisms. Here, we show that internal Nm mod ... Full text Open Access Link to item Cite

Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression.

Journal article mBio · June 11, 2019 While it has been known for several years that viral RNAs are subject to the addition of several distinct covalent modifications to individual nucleotides, collectively referred to as epitranscriptomic modifications, the effect of these editing events on v ... Full text Link to item Cite

N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression.

Journal article Oncotarget · July 27, 2018 The mRNA modification N6-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes with phenotypic outputs during c ... Full text Link to item Cite

Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.

Journal article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · March 2018 Accumulating data support a role for bioactive lipids as mediators of lipotixicity in cardiomyocytes. One class of these, the ceramides, constitutes a family of molecules that differ in structure and are synthesized by distinct enzymes, ceramide synthase ( ... Full text Cite

Getting to the heart of the sphingolipid riddle

Journal article Current Opinion in Physiology · February 2018 Full text Cite

N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.

Journal article RNA · September 2017 Post-transcriptional regulation of mRNA during oxygen deprivation, or hypoxia, can affect the survivability of cells. Hypoxia has been shown to increase stability of a subset of ischemia-related mRNAs, including VEGF. RNA binding proteins and miRNAs have b ... Full text Link to item Cite

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.

Journal article Cell Host Microbe · November 9, 2016 The RNA modification N6-methyladenosine (m6A) post-transcriptionally regulates RNA function. The cellular machinery that controls m6A includes methyltransferases and demethylases that add or remove this modification, as well as m6A-binding YTHDF proteins t ... Full text Link to item Cite

SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes.

Journal article Journal of lipid research · December 2015 Steatohepatitis occurs in up to 20% of patients with fatty liver disease and leads to its primary disease outcomes, including fibrosis, cirrhosis, and increased risk of hepatocellular carcinoma. Mechanisms that mediate this inflammation are of major intere ... Full text Cite

A Role for Mast Cells in Alcohol-Induced Tissue Damage and Remodeling

Journal article Journal of Clinical and Experimental Pathology · 2015 Full text Cite

Activation of cardiac fibroblasts by ethanol is blocked by TGF-β inhibition.

Journal article Alcoholism, clinical and experimental research · August 2013 BackgroundAlcohol abuse is the second leading cause of dilated cardiomyopathy, a disorder specifically referred to as alcoholic cardiomyopathy (ACM). Rodent and human studies have revealed cardiac fibrosis to be a consequence of ACM, and prior stu ... Full text Cite

Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts.

Journal article Life sciences · March 2013 AimsCardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models ... Full text Cite

Alterations in cardiac structure and function in a murine model of chronic alcohol consumption.

Journal article Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · June 2012 Male, wild-type, FVB strain mice were fed a nutritionally complete liquid diet supplemented with 4% ethanol v/v over a time course of 1, 2, 4, 8, 12, and 14 weeks. Controls were offered an isocaloric liquid equivalent and pair fed with their ethanol counte ... Full text Cite

Diabetes-induced alterations in the extracellular matrix and their impact on myocardial function.

Journal article Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · February 2012 Diabetes is an increasing public health problem that is expected to escalate in the future due to the growing incidence of obesity in the western world. While this disease is well known for its devastating effects on the kidneys and vascular system, diabet ... Full text Cite

Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells.

Journal article Cardiovascular research · December 2011 AimsSubstance P and neurokinin A (NKA) are sensory nerve neuropeptides encoded by the TAC1 gene. Substance P is a mast cell secretagogue and mast cells are known to play a role in adverse myocardial remodelling. Therefore, we wondered whether subs ... Full text Cite

A putative azoreductase gene is involved in the Shewanella oneidensis response to heavy metal stress.

Journal article Applied microbiology and biotechnology · April 2009 The Shewanella oneidensis MR-1 gene SO3585, which is annotated as a putative flavin mononucleotide-dependent azoreductase, shares 28% sequence identity with Bacillus subtilis azoreductase and Pseudomonas putida ChrR, a soluble flavoprotein exhibiting chrom ... Full text Cite