Scholars@Duke
Bruce Robert Smoller

Bruce Robert Smoller

Medical Professor in the Department of Pathology
Pathology
Duke Box 3712, Durham, NC 27710
RN 3117 DS, Durham, NC

Scholarly Works

Insights into basal cell carcinoma with bone metastasis: a comprehensive review.

Journal article Skin Health Dis · June 2025 Basal cell carcinoma (BCC), the most common skin cancer worldwide, is closely associated with sunlight exposure and generally exhibits a low metastatic potential, with a frequency ranging from 0.0028% to 0.55%. Despite its rarity, BCC with bony metastases ... Full text Link to item Cite

Carboxytherapy in management of acne flare in patients with moderate to severe acne vulgaris under treatment with oral isotretinoin: a case series.

Journal article Arch Dermatol Res · February 22, 2025 Oral isotretinoin is successfully used for the treatment of moderate and severe acne vulgaris and prevention of acne scars and its psychosocial sequels. Acne flare as an adverse event of this agent, which is characterized by an initial exacerbation of acne ... Full text Link to item Cite

Clinical implication of PRAME immunohistochemistry in differentiating melanoma in situ and dysplastic nevus in non-acral nevus-associated melanoma in situ: An institutional experience and meta-analysis.

Journal article J Cutan Pathol · October 2024 INTRODUCTION: PReferentially expressed Antigen in MElanoma (PRAME) has shown utility in differentiating benign from malignant melanocytic neoplasms. In this study, we investigated the clinical significance of PRAME expression in dysplastic nevi (DN) and ne ... Full text Link to item Cite

'Eczematous' dermatitis of the nipple: clinical and histopathological differential diagnosis of Paget disease.

Journal article Pathology · April 2024 The nipple can be affected by many malignant and benign entities. A wide variety of diseases including Paget disease, atopic dermatitis and nipple candidiasis can cause eczema-like changes in the nipple. In cases of diagnostic uncertainty, tissue sampling ... Full text Link to item Cite

Diagnosing Cutaneous Melanocytic Tumors in the Molecular Era: Updates and Review of Literature.

Journal article Dermatopathology (Basel) · January 18, 2024 Over the past decade, molecular and genomic discoveries have experienced unprecedented growth, fundamentally reshaping our comprehension of melanocytic tumors. This review comprises three main sections. The first part gives an overview of the current genom ... Full text Link to item Cite

Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders.

Journal article Dermatopathology (Basel) · December 21, 2023 Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the granular layer that serves as a gatekeeper of the paracellular pathway. The aim of this stud ... Full text Link to item Cite

Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides.

Journal article Dermatopathology (Basel) · October 23, 2023 Programmed cell death protein 1 (PD-1) plays a pivotal role in immune system regulation, with its expression levels linked to malignancy prognosis. However, existing reports on PD-1 staining in mycosis fungoides (MF) present conflicting findings, and littl ... Full text Link to item Cite

TRPS1: A Marker of Follicular Differentiation.

Journal article Dermatopathology (Basel) · June 14, 2023 The trichorhinophalangeal syndrome type 1 (TRPS1) immunohistochemical (IHC) stain has increased in use in recent years as a marker for breast carcinomas. The TRPS1 gene is involved in various tissues, including the growth and differentiation of hair follic ... Full text Link to item Cite

Two distinct pathogenic pathways of digital papillary adenocarcinoma - BRAF mutation or low-risk HPV infection.

Journal article J Cutan Pathol · June 2023 Digital papillary adenocarcinoma (DPA) is a rare neoplasm that can exhibit local recurrence and distant metastasis. We present a series of eight cases of DPA showing two distinct clinical presentations, morphologies, immunophenotypes, and molecular feature ... Full text Link to item Cite

Histopathologic Aspects of Malignancy-Associated Granuloma Annulare: A Single Institution Experience.

Journal article Dermatopathology (Basel) · March 4, 2023 Granuloma annulare (GA) is a benign, self-limiting granulomatous inflammatory disease that exhibits different histologic patterns. Infrequently, granuloma annulare can be associated with malignancy, the so-called malignancy-associated granuloma annulare (M ... Full text Link to item Cite

FLI-1/Melan-A dual stain is an alternative to PRAME in differentiating metastatic melanoma from nodal nevus: A monocentric retrospective study.

Journal article J Cutan Pathol · March 2023 Melanocytic nevi existing in lymph nodes create a diagnostic challenge by mimicking metastases. PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemical (IHC) stain can differentiate one from another. FLI-1 IHC expression has been shown in ... Full text Link to item Cite

TRPS1 Is Differentially Expressed in a Variety of Malignant and Benign Cutaneous Sweat Gland Neoplasms.

Journal article Dermatopathology (Basel) · February 2, 2023 Neoplasms of sweat glands and the breast may be morphologically and immunophenotypically similar. A recent study showed that TRPS1 staining is a highly sensitive and specific marker for breast carcinoma. In this study, we analyzed TRPS1 expression in a spe ... Full text Link to item Cite

Absence of TFE3 Immunoexpression in a Spectrum of Cutaneous Mixed Tumors: A Retrospective Pilot Study.

Journal article Dermatopathology (Basel) · January 29, 2022 BACKGROUND: Cutaneous mixed tumors (CMTs) include benign, atypical, and malignant chondroid syringomas. This spectrum of entities is known to be a part of myoepithelial neoplasms, which display considerable genetic heterogeneity. In a previous report, a ma ... Full text Link to item Cite

Weak immunohistochemical expression of galectin-3 near blisters in Hailey-Hailey disease.

Journal article J Cutan Pathol · January 2022 BACKGROUND: Hailey-Hailey disease (HHD) is an uncommon hereditary and benign skin condition characterized by blisters and erosions on intertriginous areas. It is related to a mutation of the ATP2C1 gene, which encodes a Ca2+ pump. It is characterized by mu ... Full text Link to item Cite

Lack of PRAME Expression in Cutaneous T-Cell Lymphomas.

Journal article Dermatopathology (Basel) · December 31, 2021 Cutaneous T-cell lymphomas (CTCLs) are rare tumors with no established markers that can reliably distinguish between benign and malignant lesions. Preferentially Expressed Antigen in Melanoma (PRAME) is a cancer/testis antigen that is found in many solid a ... Full text Link to item Cite

Evaluation of Melanocyte Loss in Mycosis Fungoides Using SOX10 Immunohistochemistry.

Journal article Dermatopathology (Basel) · July 8, 2021 Mycosis fungoides (MF) is a subtype of primary cutaneous T-cell lymphoma (CTCL) with an indolent course that rarely progresses. Histologically, the lesions display a superficial lymphocytic infiltrate with epidermotropism of neoplastic T-cells. Hypopigment ... Full text Link to item Cite

GLUT1 Expression in Cutaneous Sebaceous Lesions Determined by Immunohistochemical Staining Patterns.

Journal article Dermatopathology (Basel) · July 5, 2021 GLUT1 is a membrane associated carrier protein that functions in the physiologic transport of glucose across cell membranes. Multiple studies have shown an increased GLUT1 expression in various tumor types and a role in cancer prognosis. The aim of this st ... Full text Link to item Cite

In memoriam: N. Scott McNutt, MD.

Journal article J Cutan Pathol · July 2021 Full text Link to item Cite

A Previously Unrecognized Granulomatous Variant of Gamma-Delta T-Cell Lymphoma.

Journal article Dermatopathology (Basel) · June 17, 2021 Primary cutaneous γδ T-cell lymphoma (PCGD-TCL) is an extremely rare and aggressive T-cell neoplasm with complex heterogeneity. We present a series of two patients who presented with firm, subcutaneous nodules and were diagnosed with PCGD-TCL. In both case ... Full text Link to item Cite

Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature.

Journal article Case Rep Pathol · 2021 Progressive nodular histiocytosis (PNH) is a rare condition characterized by progressive eruption of multiple yellowish-brown papules and nodules on the skin and mucous membranes. We present the case of a 37-year-old Caucasian man with gradually increased ... Full text Link to item Cite

Histologic mimics of malignant melanoma.

Journal article Singapore Med J · November 2018 Although spongiotic (eczematous), psoriatic and cutaneous skin infections are among the most common in dermatology consultations, melanocytic lesions - including the different types of nevi and melanomas - are among those that cause a great deal of concern ... Full text Link to item Cite

Vitamin D supplementation for vitiligo.

Journal article Dermatol Ther · November 2017 Full text Link to item Cite

Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a highly sensitive marker of sebaceous differentiation in normal and neoplastic sebocytes.

Journal article J Cutan Pathol · August 2016 BACKGROUND: Sebaceous proliferations are common and may be confused with other cutaneous neoplasms. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. We incidentally observed strong factor XIIIa (Ventana clone ... Full text Link to item Cite

Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms.

Journal article J Cutan Pathol · August 2016 Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceou ... Full text Link to item Cite

Characterization of dermatopathology fellowship applicants: a 5-year single institution experience.

Journal article J Cutan Pathol · May 2016 BACKGROUND: Although much data have been documented on the characteristics of medical school applicants for dermatology and pathology residency programs in the United States and select medical and surgical fellowship applicants through the National Residen ... Full text Link to item Cite

An overview of cutaneous T cell lymphomas.

Journal article F1000Res · 2016 Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of extranodal non-Hodgkin's lymphomas that are characterized by a cutaneous infiltration of malignant monoclonal T lymphocytes. They typically afflict adults with a median age of 55 to 60 years, ... Full text Link to item Cite

Oral mucosal manifestations of autoimmune skin diseases.

Journal article Autoimmun Rev · October 2015 A group of autoimmune diseases is characterised by autoantibodies against epithelial adhesion structures and/or tissue-tropic lymphocytes driving inflammatory processes resulting in specific pathology at the mucosal surfaces and the skin. The most frequent ... Full text Link to item Cite

Epithelioid melanocytic nevus with tubule and pseudoacini formation.

Journal article J Cutan Pathol · March 2015 A 26-year-old female presented with a 7 mm irritated pink-red papule on the left posterior shoulder. A shave biopsy revealed a dermal proliferation of epithelioid cells arranged in small nests with central lumen-like structures resembling glands set in a d ... Full text Link to item Cite

Expression of PTEN in mycosis fungoides and correlation with loss of heterozygosity.

Journal article Am J Dermatopathol · July 2013 BACKGROUND: Mycosis fungoides (MF) exhibits a variety of underlying molecular defects including aberrations involving the PTEN tumor suppressor gene. Specifically, loss of heterozygosity of PTEN has been previously demonstrated. We hypothesize that abnorma ... Full text Link to item Cite

Epigenetic and immunohistochemical characterization of the Clusterin gene in ovarian tumors.

Journal article Arch Gynecol Obstet · May 2013 PURPOSE: To characterize abnormal epigenetic changes and protein expression of the clusterin gene in a large series of ovarian malignant and borderline tumors. METHODS: Protein expression and promoter methylation of clusterin gene in 181 primary ovarian ep ... Full text Link to item Cite

Dermatopathology updates on melanocytic lesions.

Journal article Dermatol Clin · October 2012 This article provides an update on histopathologic studies of different types of melanocytic lesions, such as site-specific nevi, "Spark's" nevi, nevi during pregnancy, and atypical dermal melanocytic proliferation, including pigmented epithelioid melanocy ... Full text Link to item Cite

Collapsing angiokeloidal dermatofibroma.

Journal article Am J Dermatopathol · October 2012 A heterogeneous group of benign fibrohistiocytic lesions has been assembled under the umbrella term, dermatofibroma. These lesions share a morphology of bland spindled cells encompassed by and intercalating through thick dermal collagen; unique variants ha ... Full text Link to item Cite

Misregulation of Rad50 expression in melanoma cells.

Journal article J Cutan Pathol · July 2012 DNA double-strand breaks are increased in human melanoma tissue as detected by histone H2AX phosphorylation.(1-3) We investigated two of the downstream effectors of DNA double-strand breaks, Rad50 and 53BP1 (tumor suppressor p53 binding protein 1), to dete ... Full text Link to item Cite

Varicella-zoster virus (VZV) and alpha 1 antitrypsin: a fatal outcome in a patient affected by endemic pemphigus foliaceus.

Journal article Int J Dermatol · July 2012 BACKGROUND: Herpes virus infections are well known infectious complications of pemphigus and bullous pemphigoid. We describe pathologic findings utilizing autopsy tissue from several organs from a patient affected by a new variant of endemic pemphigus in E ... Full text Link to item Cite

A case of cutaneous Scedosporium infection in an immunocompromised patient.

Journal article J Cutan Pathol · April 2012 Scedosporium apiospermum, the asexual stage of Pseudoallescheria boydii, is a fungus ubiquitous in soil as well as organically polluted areas, where nitrogen-containing compounds are abundant. It is an emerging opportunistic pathogen that can range from cu ... Full text Link to item Cite

Association between natural killer cells and regression in melanocytic lesions.

Journal article Hum Pathol · December 2011 Mortality from melanoma, the deadliest of skin cancers, continues to increase in all age groups. A small number of melanomas spontaneously regress. In vitro studies suggest a role for the natural killer cell in effecting regression. In this study, the goal ... Full text Link to item Cite

Evaluation of a novel high-intensity focused ultrasound device for ablating subcutaneous adipose tissue for noninvasive body contouring: safety studies in human volunteers.

Journal article Aesthet Surg J · May 2011 BACKGROUND: High-intensity focused ultrasound (HIFU) is an energy-based medical technology with many clinical applications. A device under clinical investigation in the United States (LipoSonix; Medicis Technologies Corporation, Bothell, Washington) uses H ... Full text Link to item Cite

Evaluation of a novel high-intensity focused ultrasound device: preclinical studies in a porcine model.

Journal article Aesthet Surg J · May 2011 BACKGROUND: High-intensity focused ultrasound (HIFU) has been applied clinically for the noninvasive treatment of pathological conditions in various organs for over 50 years; however, there are little data describing the use of thermal HIFU to ablate fat f ... Full text Link to item Cite

Comparison between Langerhans cell concentration in lichen planopilaris and traction alopecia with possible immunologic implications.

Journal article Am J Dermatopathol · May 2011 Lichen planopilaris and long-standing traction alopecia are both traditionally classified as scarring alopecias. The etiology of lichen planopilaris has not been fully elucidated, although an autoimmune mechanism is generally accepted with Langerhans cell ... Full text Link to item Cite

Bullous allergic drug eruption with presence of myeloperoxidase and reorganization of the dermal vessels observed by using CD34 and collagen IV antibodies.

Journal article N Am J Med Sci · February 2011 CONTEXT: Bullous allergic reactions are inflammatory skin disorders, presenting usually as a result of some type of reaction to medication. CASE REPORT: A 67-year-old female was evaluated for the presence of diffuse patches of erythema, microvesiculation, ... Full text Link to item Cite

Antibodies to pilosebaceous units along their neurovascular supply routes in a new variant of endemic pemphigus foliaceus in Colombia, South America.

Journal article Eur J Dermatol · 2011 Senear Usher syndrome is a variant of pemphigus foliaceus, confined to seborrheic sites and considered to be a clinical overlap syndrome, with features of both pemphigus foliaceus and lupus erythematosus. We recently described autoantibodies to skin eyelid ... Full text Link to item Cite

Influence of evaluation of clinical pictures on the histopathologic diagnosis of inflammatory skin disorders.

Journal article J Am Acad Dermatol · October 2010 BACKGROUND: Clinical information on histologic referral sheets is usually very limited, and particularly for inflammatory skin disorders, dermatopathologists often ask referring physicians for clinical correlation. OBJECTIVE: In this study we tested the va ... Full text Link to item Cite

Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) arising on the extremities.

Journal article J Cutan Pathol · October 2010 BACKGROUND: Epithelioid hemangioma (EH) is a benign vascular proliferation usually accompanied by a mixed inflammatory infiltrate. METHODS: Skin biopsy specimens from four patients with EH on the extremities were studied. Architecture, extent of vascular p ... Full text Link to item Cite

Formalin deposition as artifact in biopsies from patients affected by a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America.

Journal article J Cutan Pathol · August 2010 BACKGROUND: Most autoimmune diseases occur sporadically; however, endemic pemphigus foliaceus (EPF) is present in specific locales restricted to some geographic rural regions mostly in South America, Central America and in Tunisia (Africa). Its geographic ... Full text Link to item Cite

New clinical outcomes utilizing a 1064-nm Nd:YAG laser for lipolysis of the torso oblique region.

Journal article J Cosmet Laser Ther · August 2010 OBJECTIVES: The safety and efficacy of a 1064-nm Nd:YAG laser (Cynosure, Westford, USA) utilizing a 300-microm optical fiber and a 1-mm diameter micro-cannula were evaluated as a treatment for reduction in the appearance or elimination of unwanted fat in t ... Full text Link to item Cite

New insights into merkel cell carcinoma.

Journal article Adv Anat Pathol · May 2010 Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement. Histologically and ... Full text Link to item Cite

Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma.

Journal article Otolaryngol Head Neck Surg · October 2009 OBJECTIVE: The study is designed to elucidate the relationship between epigenetic silencing of the hMLH1 (human MutL homologue 1) gene and microsatellite instability (MSI) and the prognostic values of hMLH1 promoter methylation and MSI in head and neck squ ... Full text Link to item Cite

Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma.

Journal article J Cutan Pathol · May 2009 Atypical fibroxanthoma (AFX), spindle cell squamous cell carcinoma (SCSCC) and spindle cell melanoma are the primary entities in the differential diagnosis of a cytologically atypical spindle cell tumor arising on sun-damaged skin. AFX is generally regarde ... Full text Link to item Cite

Reply: Letter to the Editor

Journal article Journal of Cutaneous Pathology · May 1, 2009 Full text Cite

A study examining the safety and efficacy of a fractional laser in the treatment of photodamage on the hands.

Journal article J Cosmet Laser Ther · March 2009 BACKGROUND: Few clinical studies have been reported in the literature documenting the efficacy of non-ablative modalities in the treatment of non-facial areas such as the hand. OBJECTIVE: The present study examined the clinical and histopathological effect ... Full text Link to item Cite

A true impact factor: N. Scott McNutt, MD.

Journal article J Cutan Pathol · November 2008 N. Scott McNutt has recently retired from his long-standing position as a Professor in Pathology and Internal Medicine (Dermatology) at Weill Medical College at Cornell University. He leaves behind a legacy that includes trainees throughout the world, many ... Full text Link to item Cite

Sampling of melanocytic nevi for research purposes: a prospective, pilot study to determine effect on diagnosis.

Journal article J Am Acad Dermatol · November 2008 BACKGROUND: Research on melanocytic nevi predominantly utilizes formalin-fixed, paraffin-embedded tissue, largely limiting research to morphologic and immunohistochemical observations. Withholding portions of fresh nevus tissue for molecular studies could ... Full text Link to item Cite

Mycosis fungoides: what do/do not we know?

Journal article J Cutan Pathol · November 2008 Mycosis fungoides is one type of T cell lymphoma characterized by a constellation of clinical, histologic, immunologic and molecular findings. Many patients follow a slowly progressive, but indolent disease course, while others have a more aggressive disea ... Full text Link to item Cite

Loss of heterozygosity of DNA repair gene, hOGG1, in renal cell carcinoma but not in renal papillary adenoma.

Journal article Pathol Int · June 2008 The kidney is constantly exposed to free radicals due to its active metabolism and processing of toxic metabolites. Among 20 or so free radical-induced DNA lesions, 8-oxoquanine is the most abundant and is potentially mutagenic if not sufficiently removed. ... Full text Link to item Cite

Concordant loss of heterozygosity of DNA repair gene, hOGG1, in melanoma in situ and atypical melanocytic hyperplasia.

Journal article J Cutan Pathol · June 2008 BACKGROUND: One major risk factor for cutaneous melanoma is chronic sun-exposure and oxidative stress. Among various oxidative DNA damages, 8-oxoquanine is the most abundant and is potentially mutagenic if not sufficiently repaired. The human 8-oxoquanine ... Full text Link to item Cite

Bcl-2, CD34 and CD10 expression in basaloid follicular hamartoma, vellus hair hamartoma and neurofollicular hamartoma demonstrate full follicular differentiation.

Journal article J Cutan Pathol · May 2008 Generalized basaloid follicular hamartoma syndrome (GBFHS) is a rare, recently-described, autosomal-dominantly inherited disorder that presents with disseminated milia, palmoplantar pitting, hypotrichosis and basaloid follicular hamartomas (BFH). BFH is a ... Full text Link to item Cite

Perceptions of stress among pathology residents: survey results and some strategies to reduce them.

Journal article Am J Clin Pathol · December 2007 We conducted a survey to attempt to identify stressors perceived by pathology residents. A comparison of survey results from pathology residents with stressors perceived by residents in other specialties was done to evaluate whether the stressors in pathol ... Full text Link to item Cite

Loss of heterozygosity analysis identifies genetic abnormalities in mycosis fungoides and specific loci associated with disease progression.

Journal article Am J Surg Pathol · October 2007 Mycosis fungoides (MF) exhibits a variety of underlying molecular defects. Loss of heterozygosity (LOH) is a technique used to detect chromosomal imbalances in neoplastic disorders using archival tissue. We analyzed skin biopsies of MF in different stages ... Full text Link to item Cite

Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells.

Journal article Carcinogenesis · August 2007 Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA repair mechanisms for oxidative DNA damage is base excision re ... Full text Link to item Cite

Fli-1 expression in mycosis fungoides.

Journal article J Cutan Pathol · September 2006 BACKGROUND: The Fli-1 transcription factor functions in cellular proliferation and tumorigenesis. Its role in various neoplasms and its presence in lymphocytes suggest a link between Fli-1 dysregulation and the pathogenesis of mycosis fungoides (MF). In th ... Full text Link to item Cite

Colchicine intoxication diagnosed in a skin biopsy: a case report.

Journal article J Cutan Pathol · April 2006 Colchicine toxicity is a rare, but well-described clinical entity. The histopathologic findings in various organ systems have been delineated in colchicine intoxication; however, skin findings have only been described in rare cases. We present a case of co ... Full text Link to item Cite

Histologic criteria for diagnosing primary cutaneous malignant melanoma.

Journal article Mod Pathol · February 2006 Malignant melanoma accounts for the largest number of deaths attributed to skin cancer. It also provides the most diagnostic challenges for the histopathologist. This article, attempts to describe the histologic features most closely associated with the va ... Full text Link to item Cite

Squamous cell carcinoma: from precursor lesions to high-risk variants.

Journal article Mod Pathol · February 2006 Cutaneous squamous cell carcinoma is second only to basal cell carcinoma in its incidence within our population. It is among the most common types of neoplasm afflicting the human race. Most cases are related to exposure to sunlight. This initial portion o ... Full text Link to item Cite

Introduction to the 2005 long course.

Journal article Mod Pathol · February 2006 Dermatopathology, as with other fields of pathology, has undergone major changes in the last 25 years. Our understanding of epidermally derived neoplasms becomes far more advanced with each passing year. Evidence for this progress is readily apparent upon ... Full text Link to item Cite

Defining early mycosis fungoides.

Journal article J Am Acad Dermatol · December 2005 This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early mycosis fungoides were critically examined. Based on this analysis, an a ... Full text Link to item Cite

Unusual histological variants of cutaneous malignant melanoma with some clinical and possible prognostic correlations.

Journal article J Cutan Pathol · October 2005 Malignant melanoma is known for the wide range of histological patterns it can assume mimicking other malignant tumors. We present a review of most of the unusual histological variants of cutaneous melanoma and describe their immunohistochemical features, ... Full text Link to item Cite

A novel somatic mutation of the 3beta-hydroxysteroid dehydrogenase gene in sporadic cutaneous verruciform xanthoma.

Journal article Arch Dermatol · October 2005 OBJECTIVE: To analyze the 3beta-hydroxysteroid dehydrogenase (NSDHL) gene in verruciform xanthoma (VX) to elucidate its potential role in the histogenesis of this lesion. DESIGN: DNA was extracted from paraffin-embedded tissue, followed by polymerase chain ... Full text Link to item Cite

Necrolytic acral erythema: a cutaneous sign of hepatitis C virus infection.

Journal article J Am Acad Dermatol · August 2005 BACKGROUND: Hepatitis C virus (HCV) infection is globally epidemic. Several mucocutaneous diseases are well established in association with HCV infection. Few case reports describe the recently recognized HCV-related skin disorder termed necrolytic acral e ... Full text Link to item Cite

Mycobacteria other than Mycobacterium tuberculosis are not present in erythema induratum/nodular vasculitis: a case series and literature review of the clinical and histologic findings.

Journal article J Cutan Pathol · March 2005 Erythema induratum (EI)/nodular vasculitis (NV) is characterized by recurrent crops of tender oedematous nodules on the lower legs. A lobular panniculitis with granulomatous inflammation, vasculitis, focal necrosis and septal fibrosis is present. Mycobacte ... Full text Link to item Cite

Exogenous trauma simulating perifollicular fibromas.

Journal article Am J Dermatopathol · February 2005 The patient is a 63-year-old woman who presented to her dermatologist for the removal of two nevi near her mouth. Histologic examination revealed melanocytic nevi showing maturation with dermal descent. Within the dermis, adjacent to these nevoid cells, we ... Full text Link to item Cite

Histiocytic subpopulations in the gastrointestinal tract: distribution and possible relationship to function.

Journal article Appl Immunohistochem Mol Morphol · December 2004 The distribution of specific histiocyte subsets within the human gastrointestinal tract has not been extensively characterized. Our goal was to immunohistochemically evaluate the distribution and location of CD1a-positive, CD68-positive, and Factor XIIIa ( ... Full text Link to item Cite

Evaluation of anti-thrombomodulin antibody as a tumor marker for vascular neoplasms.

Journal article J Cutan Pathol · November 2004 BACKGROUND: Various endothelial markers are available for the evaluation of vascular tumors and malformations, including anti CD34, anti-CD31, von Willebrand factor (vWF), and anti-thrombomodulin (anti-TM) antibodies. All have their limitations, and we sou ... Full text Link to item Cite

Cutaneous angiosarcoma: a case series with prognostic correlation.

Journal article J Am Acad Dermatol · June 2004 BACKGROUND: Cutaneous angiosarcoma (CA) is a rare and aggressive endothelial-derived sarcoma. Few large studies have examined the clinicopathologic and prognostic attributes of CA. OBJECTIVES: We sought to discern the potential prognostic significance of a ... Full text Link to item Cite

Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas.

Journal article Mod Pathol · May 2004 Matrix metalloproteinases compose a family of enzymes involved in degradation of the extracellular matrix. Tumor cells must penetrate the basement membrane and traverse the extracellular matrix in order to invade surrounding structures and metastasize to d ... Full text Link to item Cite

Merkel cell carcinoma: a clinicopathologic study with prognostic implications.

Journal article J Cutan Pathol · March 2004 BACKGROUND: Merkel cell carcinoma (MCC) is a frequently aggressive neuroendocrine malignancy of the skin that presents in sun-exposed areas on elderly patients. Although originally described over 30 years ago, many aspects of MCC remain to be defined. Of p ... Full text Link to item Cite

The pustular disorders.

Journal article Semin Cutan Med Surg · March 2004 The pustular disorders constitute a subgroup of the vesiculobullous disorders defined by the presence of eosinophils or neutrophils with prominent accompanying intercellular edema or a canthelysis involving various levels of the epithelium. Herein, we desc ... Full text Link to item Cite

Tissue and tumor mosaicism of the myotonin protein kinase gene trinucleotide repeat in a patient with multiple basal cell carcinomas associated with myotonic dystrophy.

Journal article J Am Acad Dermatol · February 2004 We describe the third case (to our knowledge) of multiple basal cell carcinoma associated with myotonic dystrophy and carry out a genetic study of the tumor comparing it with healthy skin. We consider that our results show that this association might be no ... Full text Link to item Cite

Ets-1 immunohistochemical expression in non-melanoma skin carcinoma.

Journal article J Cutan Pathol · January 2004 BACKGROUND: Ets-1 oncoprotein is a transcription factor known to regulate the expression of numerous genes important in extracellular matrix remodeling and angiogenesis. Up-regulation of Ets-1 has been shown to be important in a variety of human malignanci ... Full text Link to item Cite

Her-2 expression in cutaneous eccrine and apocrine neoplasms.

Journal article Mod Pathol · January 2004 Cutaneous eccrine and apocrine glands have many histologic and immunologic similarities to ducts and acini of the breast. Thus, differentiating a primary cutaneous process from a metastatic breast carcinoma can be nearly impossible. In all, 10-34% of breas ... Full text Link to item Cite

Histopathology and genetics of cutaneous T-cell lymphoma.

Journal article Hematol Oncol Clin North Am · December 2003 There is emerging evidence that genomic and chromosomal instability are features of CTCL, including variants such as MF, Sézary syndrome, and primary cutaneous CD30+ LCAL, and that specific chromosomal abnormalities are common. Additional resolution of spe ... Full text Link to item Cite

E-cadherin promoter hypermethylation in preneoplastic and neoplastic skin lesions.

Journal article Mod Pathol · October 2003 E-cadherin is a calcium-dependent, intercellular adhesion molecule that is specifically expressed in epithelial tissues and plays an important role in maintaining epithelial stability. E-cadherin is widely regarded as a prognostic marker in many types of h ... Full text Link to item Cite

Dermatofibroma: upregulation of syndecan-1 expression in mesenchymal tissue.

Journal article Am J Dermatopathol · October 2003 Cell surface proteoglycans play a prominent role in tissue remodeling and homeostasis. Syndecans, their most prominent members, act by binding to growth factors and interstitial matrix molecules. They, thereby, modulate the effect of the primary ligand-rec ... Full text Link to item Cite

Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms.

Journal article Mod Pathol · October 2003 In non-neoplastic tissues, the expression of protein gene product 9.5 (PGP 9.5), a member of the ubiquitin hydrolase family of proteins, is confined to neural and neuroendocrine cells. Although it has been claimed that PGP 9.5 is a specific marker of neura ... Full text Link to item Cite

Seasonal effect upon excision of acquired melanocytic proliferations.

Journal article Int J Dermatol · September 2003 BACKGROUND: Acquired melanocytic proliferations (AMPs) are excised throughout the year. Questions exist concerning seasonal variation in these excisions. OBJECTIVE: To investigate whether AMPs are removed more often during the spring-summer seasons than in ... Full text Link to item Cite

Leukocytoclastic (small vessel) vasculitis in multiple myeloma.

Journal article Clin Exp Dermatol · September 2003 The hallmark of leukocytoclastic vasculitis (LCV) is palpable purpura. Histologically, there is a neutrophilic, angiocentric, segmental inflammation with endothelial cell injury and fibrinoid necrosis of the blood vessel walls. Leukocytoclastic vasculitis ... Full text Link to item Cite

Necrolytic migratory erythema as the only presenting sign of a glucagonoma.

Journal article J Am Acad Dermatol · August 2003 We describe a 39-year-old man with a 3-year history of a recalcitrant psoriasiform eruption that was accentuated in the intertriginous areas. Hsitopathology was consistent with psoriasis. A glucagon level was 744 pg/mL with the upper limit of normal being ... Full text Link to item Cite

Expression of the ets-1 proto-oncogene in melanocytic lesions.

Journal article Mod Pathol · August 2003 Ets-1 oncoprotein is a transcription factor known to regulate the expression of numerous genes important in extracellular matrix remodeling and angiogenesis. Up-regulation of Ets-1 has been shown to be important in a variety of human malignancies and to co ... Full text Link to item Cite

Sezary syndrome: cutaneous immunoperoxidase double-labeling technique demonstrates CD4/CD8 ratio non-specificity.

Journal article J Cutan Pathol · August 2003 BACKGROUND: Sezary syndrome (SS) is an erythrodermic cutaneous T-cell lymphoma with a leukemic component. Biopsies from these patients may suggest erythrodermic mycosis fungoides or SS but most often are not diagnostic. Additional methods are therefore usu ... Full text Link to item Cite

Analysis of promoter hypermethylation of death-associated protein kinase and p16 tumor suppressor genes in actinic keratoses and squamous cell carcinomas of the skin.

Journal article Mod Pathol · July 2003 Death-associated protein kinase is a serine/threonine protein kinase implicated in promoting apoptosis and tumor suppression, whereas p16 is a tumor suppressor gene that inhibits cyclin-dependent kinase 4 and 6 activity and arrests the cell cycle in the G1 ... Full text Link to item Cite

Localized epidermolytic hyperkeratosis of the female external genitalia.

Journal article J Cutan Pathol · July 2003 BACKGROUND: Epidermolytic hyperkeratosis (EH) is most commonly associated with the diffuse involvement of congenital ichthyosiform erythroderma, but can also be found in a localized pattern. Localized EH is rare, but mucocutaneous lesions have been been id ... Full text Link to item Cite

Telepathology in the diagnosis of routine dermatopathologic entities.

Journal article Arch Dermatol · May 2003 BACKGROUND: Telepathology involves the use of video technology to facilitate remote-site diagnosis. To our knowledge, no studies have compared the reproducibility of real-time telepathology between dermatopathologists with that of traditional 2-headed micr ... Full text Link to item Cite

Histopathologic evaluation of cutaneous squamous cell carcinoma: results of a survey among dermatopathologists.

Journal article J Am Acad Dermatol · May 2003 BACKGROUND: There are numerous histopathologic features related to prognosis in cutaneous squamous cell carcinoma (CSCC). We hypothesize that there is no uniform approach toward the reporting of these features. This may be related to differing opinions on ... Full text Link to item Cite

Sweet syndrome in multiple myeloma: a series of six cases.

Journal article J Cutan Pathol · April 2003 BACKGROUND: Sweet syndrome (SS), a paraneoplastic syndrome characterized by fever, neutrophilia, multiple erythematous painful plaques, and a dense dermal neutrophilic infiltration, has a known association with hematologic malignancies such as acute myelog ... Full text Link to item Cite

Granuloma annulare and malignant neoplasms.

Journal article Am J Dermatopathol · April 2003 The relationship between granuloma annulare (GA) and malignant neoplasms is uncertain. Several case reports and clinical correlation studies have addressed this issue; however, no review articles have summarized those reported cases and statistically analy ... Full text Link to item Cite

The spectrum of cutaneous disease in multiple myeloma.

Journal article J Am Acad Dermatol · April 2003 BACKGROUND: Multiple myeloma (MM) is a plasma cell dyscrasia characterized by a clonal proliferation of plasma cells that produces a monoclonal protein. There are dermatologic disorders that have been associated with MM, such as amyloidosis, cryoglobulinem ... Full text Link to item Cite

Syringocystadenoma papilliferum contiguous to a verrucous cyst.

Journal article J Cutan Pathol · January 2003 BACKGROUND: Syringocystadenoma papilliferum (SCAP) and verrucous cyst are two uncommon benign tumors. The simultaneous occurrence of the two lesions has not been reported before. METHODS: We report four cases of the simultaneous occurrence of the two rare ... Full text Link to item Cite

VCAM (CD-106) and ICAM (CD-54) adhesion molecules distinguish keratoacanthomas from cutaneous squamous cell carcinomas.

Journal article Mod Pathol · January 2003 Keratoacanthomas are rapidly growing benign epithelial derived neoplasms that may evolve into squamous cell carcinomas, or represent a variant of squamous cell carcinoma. ICAM (CD-54) is a ligand for the cell adhesion receptor LFA-1, shown to be important ... Full text Link to item Cite

Expression of syndecan-1 is a sensitive marker for cutaneous plasmacytoma.

Journal article J Cutan Pathol · January 2003 BACKGROUND: Cutaneous plasmacytoma is a well-recognized, yet infrequent, occurrence in multiple myeloma (MM). There are limitations in the morphologic assessment, and as such, the diagnosis presents some difficulty, particularly with the plasmablastic type ... Full text Link to item Cite

Syndecan-1 is strongly expressed in the anagen hair follicle outer root sheath and in the dermal papilla but expression diminishes with involution of the hair follicle.

Journal article Am J Dermatopathol · December 2002 Syndecan-1 is the prototypic member of a family of heparan sulfate-bearing cell surface proteoglycans that function in adhesion, cell-extracellular matrix interactions, migration, and proliferation. During embryogenesis, syndecan-1 expression in the epithe ... Full text Link to item Cite

Immunohistochemical comparison of p16 expression in actinic keratoses and squamous cell carcinomas of the skin.

Journal article Mod Pathol · November 2002 There are approximately 200,000 new cases of cutaneous squamous cell carcinoma diagnosed each year in the United States, with between 1300 and 2300 deaths per year from metastatic disease. The tumor suppressor p16, encoded by the CDKN2/INK4a locus, has bee ... Full text Link to item Cite

Expression of CD44 and CD44v6 in primary cutaneous CD30 positive T-cell lymphoproliferative disorders.

Journal article J Cutan Pathol · September 2002 BACKGROUND: Expression of the lymphocyte homing receptor CD44 and its variant form, CD44v6, have been linked to unfavorable prognosis and tumor dissemination in non-Hodgkin's lymphoma. The role of CD44 and CD44v6 in primary cutaneous lymphomas may not nece ... Full text Link to item Cite

Eccrine nevus presenting as a perianal skin tag: a case report and review of the literature.

Journal article Am J Dermatopathol · August 2002 We present the case of a 9-year-old girl with a perianal skin tag. This asymptomatic lesion was removed for cosmetic reasons and demonstrated a polypoid lesion with a slightly acanthotic epidermis. The dermis was filled with mature-appearing eccrine ducts ... Full text Link to item Cite

h-Caldesmon as a specific marker of smooth muscle cell differentiation in some soft tissue tumors of the skin.

Journal article J Cutan Pathol · August 2002 BACKGROUND: An existing problem in contemporary pathology is the classification and distinction of spindle cell soft tissue tumors of the skin. Markers such as alpha-smooth muscle actin (alpha-SMA) and desmin, considered specific for smooth muscle cell (SM ... Full text Link to item Cite

AL amyloidosis is not present as an incidental finding in cutaneous biopsies of patients with multiple myeloma.

Journal article Clin Exp Dermatol · May 2002 Multiple myeloma (MM) is a monoclonal B-cell neoplasm characterized by autonomous proliferation of immunoglobulin-secreting plasma cells that are capable of synthesizing amyloidogenic light chains resulting in AL amyloidosis. Clinically occult AL amyloid d ... Full text Link to item Cite

Association of expression of CD44v6 with systemic anaplastic large cell lymphoma: comparison with primary cutaneous anaplastic large cell lymphoma.

Journal article Am J Clin Pathol · February 2002 CD44 is a ubiquitous multifunctional cell surface adhesion molecule family. High expression of the standard form, CD44s (CD44), and its variant form, CD44v6, has been reported to be associated with tumor dissemination in non-Hodgkin lymphoma. To evaluate t ... Full text Link to item Cite

A spindled cell CD34+ dermal proliferation.

Journal article Am J Dermatopathol · February 2002 Full text Link to item Cite

The level of syndecan-1 expression is a distinguishing feature in behavior between keratoacanthoma and invasive cutaneous squamous cell carcinoma.

Journal article Mod Pathol · January 2002 Keratoacanthoma (KA) resolves spontaneously but is regarded by some as a variant of squamous cell carcinoma (SCC). However, others consider KA a totally benign entity. Syndecan-1 is one of the heparan sulfate proteoglycans that mediates intercellular and c ... Full text Link to item Cite

Caveolin expression is common among benign and malignant smooth muscle and adipocyte neoplasms.

Journal article Mod Pathol · January 2002 The caveolins belong to a newly described group of membrane-scaffolding proteins. Their presence in benign endothelial cells has been used to discriminate benign from malignant vascular neoplasms. The extent of caveolin expression in cutaneous mesenchymal ... Full text Link to item Cite

Granuloma annulare: another manifestation of Bartonella infection?

Journal article Am J Dermatopathol · December 2001 Granuloma annulare (GA) is a common cutaneous eruption whose pathogenesis remains unknown. Recent literature has suggested a relation between Borrelia infection and GA, a relation that has not been widely accepted. Earlier works attempted unsuccessfully to ... Full text Link to item Cite

Characterization of interdigital glands in the Asian elephant (Elephas maximus).

Journal article Res Vet Sci · December 2001 In the Asian elephant, wetness akin to perspiration is commonly observed on the cuticles and interdigital areas of the feet; this observation has lead to speculation regarding the existence of an interdigital gland. Our goal was to search for interdigital ... Full text Link to item Cite

Absence of Borrelia burgdorferi DNA in cutaneous B-cell lymphomas from the United States.

Journal article J Cutan Pathol · November 2001 BACKGROUND: An association between Borrelia burgdorferi and cutaneous B-cell lymphoma (CBCL) has been made in several European countries. The evidence in favor of such an association has recently been based on more definitive tests for the pathogenetic rol ... Full text Link to item Cite

Medical pearl: new views through the microscope.

Journal article J Am Acad Dermatol · July 2001 Full text Link to item Cite

Expression of the human erythrocyte glucose transporter Glut-1 in areas of sclerotic collagen in necrobiosis lipoidica.

Journal article J Cutan Pathol · July 2001 BACKGROUND: Glut-1 is the human erythrocyte glucose transporter which mediates facilitative transport of glucose across epithelial and endothelial barrier tissues. A primary abnormality in glucose transport and Glut-1 cell-surface content has been observed ... Full text Link to item Cite

The role of androgen receptors in the clinical course of nevus sebaceus of Jadassohn.

Journal article Mod Pathol · June 2001 Nevus sebaceus of Jadassohn (NSJ) is a benign, congenital hamartoma that often presents at birth, appears to regress in childhood, and grows during puberty, suggesting possible hormonal control. We studied 18 cases of NSJ from children and adults for immun ... Full text Link to item Cite

Reassessment of lymphocytic atypia in the diagnosis of mycosis fungoides.

Journal article Mod Pathol · April 2001 The manifestations of mycosis fungoides in its early stage may mimic clinically and histologically those of many benign inflammatory dermatoses. Therefore, the diagnosis of mycosis fungoides remains a major challenge for dermatologists and dermatopathologi ... Full text Link to item Cite

Acantholysis and spongiosis are associated with loss of syndecan-1 expression.

Journal article J Cutan Pathol · March 2001 BACKGROUND: Syndecan-1, a heparan sulfate proteoglycan present on the membrane of keratinocytes, functions in intercellular adhesion. Acantholysis and spongiosis are both characterized by diminished intercellular adhesion that may lead to blister formation ... Full text Link to item Cite

The expression of syndecan-1 is preferentially reduced compared with that of E-cadherin in acantholytic squamous cell carcinoma.

Journal article J Cutan Pathol · February 2001 BACKGROUND: Syndecan-1 and E-cadherin are cell adhesion molecules which are expressed primarily on the surface of adult epithelial cells. They appear to be co-regulated and may act in concert to stabilize the epithelium. Loss of expression of both E-cadher ... Full text Link to item Cite

Immunohistochemical stains in dermatopathology.

Journal article J Am Acad Dermatol · December 2000 Full text Link to item Cite

Solitary fibrous tumors are immunophenotypically distinct from mesothelioma(s).

Journal article J Cutan Pathol · October 2000 INTRODUCTION: Solitary fibrous tumor is a soft tissue tissue tumor of unknown histogenesis. Based upon histologic similarities and CD-34 expression, it has been suggested that these neoplasms bear some relationship to mesothelioma, and may represent its ex ... Full text Link to item Cite

The histologic value of adnexal (eccrine gland and follicle) infiltration in mycosis fungoides.

Journal article J Cutan Pathol · September 2000 BACKGROUND: To verify the incidence and the possible diagnostic use of detecting adnexotropism in mycosis fungoides (MF). METHODS: We reviewed the frequency and the intensity of the eccrine and follicular infiltration in 104 biopsy specimens from indisputa ... Full text Link to item Cite

Pagetoid reticulosis (Woringer-Kolopp disease): an immunophenotypic, molecular, and clinicopathologic study.

Journal article Mod Pathol · May 2000 Pagetoid reticulosis (PR), also known as Woringer-Kolopp disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients ... Full text Link to item Cite

Syndecan-1 expression is decreased with increasing aggressiveness of basal cell carcinoma.

Journal article Am J Dermatopathol · April 2000 Syndecans, a family of cell-surface proteoglycans of which syndecan-1 is the prototypical member, play an important role in limiting tumor growth and invasive capacity through their actions as receptors for growth factors and extracellular matrix. Cutaneou ... Full text Link to item Cite

The microanatomy of the distal arrector pili: possible role for alpha1beta1 and alpha5beta1 integrins in mediating cell-cell adhesion and anchorage to the extracellular matrix.

Journal article J Cutan Pathol · February 2000 The arrector pili (AP) muscle is a small band of smooth muscle that attaches proximally to the bulge area of the pilosebaceous apparatus in the reticular dermis and extends up toward the epidermis. The distal anatomy of the AP and the anchorage mechanism a ... Full text Link to item Cite

Androgen receptors: a marker to increase sensitivity for identifying breast cancer in skin metastasis of unknown primary site.

Journal article Mod Pathol · February 2000 Metastatic lesions to the skin may present a dilemma in the identification of the primary site. Breast carcinoma, metastatic to the skin, that is negative for estrogen receptors (ERs) and/or progesterone receptors (PRs) may be mimicked by a number of other ... Full text Link to item Cite

Increased p53 staining in normal skin of posttransplant, immunocompromised patients and implications for carcinogenesis.

Journal article Am J Dermatopathol · October 1999 The p53 tumor suppressor gene is a transcriptional activator involved in control of cell cycle. Nonmelanoma skin cancers and premalignant lesions in transplant patients have been associated with an increased rate of p53 mutation. It is possible that normal ... Full text Link to item Cite

Immunohistochemical staining for androgen receptors: a sensitive marker of sebaceous differentiation.

Journal article Am J Dermatopathol · October 1999 Androgen receptors (AR) are present in normal skin being localized to the basal and differentiating cells of the sebaceous gland, and as such, sebaceous glands are androgen sensitive tissue. Androgen receptor expression was examined in 43 sebaceous neoplas ... Full text Link to item Cite

Syndecan-1 expression is diminished in acantholytic cutaneous squamous cell carcinoma.

Journal article J Cutan Pathol · September 1999 Syndecan-1 is a cell surface proteoglycan predominantly expressed on the surface of adult epithelial cells, and is normally present in all epidermal layers except for the most superficial terminally differentiated cells. Syndecan-1 mediates cell-cell and c ... Full text Link to item Cite

Immunohistochemical evaluation of androgen receptors in genital and extragenital lichen sclerosus: evidence for loss of androgen receptors in lesional epidermis.

Journal article J Am Acad Dermatol · July 1999 BACKGROUND: Reduction of lichen sclerosus has been seen with topical testosterone, and spontaneous resolution has been attributed to increasing androgen levels. OBJECTIVE: Our purpose was to investigate the role of androgens in lichen sclerosus by studying ... Full text Link to item Cite

Basal cell carcinoma: a comparison of shave biopsy versus punch biopsy techniques in subtype diagnosis.

Journal article J Am Acad Dermatol · July 1999 BACKGROUND: There are two standard ways to obtain tissue for histologic classification of a clinically suspected basal cell carcinoma: shave and punch biopsy. However, information on the value of each method is limited. OBJECTIVE: The purpose of this study ... Full text Link to item Cite

Immunohistochemistry in diagnostic dermatopathology.

Journal article Dermatol Clin · July 1999 This article briefly reviews many immunohistochemical stains that have been in use for years, emphasizing their diagnostic use and potential pitfalls. Several newer immunostains are described in a more comprehensive fashion, including brief summaries from ... Full text Link to item Cite

Aggressive cutaneous NK and NK-like T-cell lymphomas: clinicopathologic, immunohistochemical, and molecular analyses of 12 cases.

Journal article Am J Surg Pathol · May 1999 Natural killer (NK) and NK-like T-cell lymphomas are rare hematolymphoid malignancies that predominate in the upper aerodigestive system. They also involve other extranodal sites, including the skin. Primary cutaneous manifestations of NK and NK-like T-cel ... Full text Link to item Cite

Spiders and Borrelia burgdorferi: no evidence of reservoir occurrence in central Arkansas.

Journal article Int J Dermatol · April 1999 BACKGROUND: Although Ixodes ticks are considered the chief vector for Borrelia burgdorferi in the USA, B. burgdorferi has also been identified in mosquitoes, horse flies, and deer flies. We examined the possibility of these organisms being harbored in two ... Full text Link to item Cite

A clinical and histologic prospective controlled comparative study of the picosecond titanium:sapphire (795 nm) laser versus the Q-switched alexandrite (752 nm) laser for removing tattoo pigment.

Journal article J Am Acad Dermatol · April 1999 BACKGROUND: Theory predicts that picosecond lasers should be more effective than the currently available nanosecond lasers in removing tattoo ink. In addition to thermal confinement, such pulse widths cause optimal photomechanical disruption of the target. ... Full text Link to item Cite

Microcystic adnexal carcinoma arising in the setting of previous radiation therapy.

Journal article J Cutan Pathol · January 1999 While there are several reports of microcystic adnexal carcinoma developing in patients within sites of previous therapeutic irradiation, this relationship is not well described in the dermatologic literature. We report a case of a 42-year-old man with a r ... Full text Link to item Cite

Safety and efficacy of high fluence CO2 laser skin resurfacing with a single pass.

Journal article J Cutan Laser Ther · January 1999 BACKGROUND: Carbon dioxide (CO2) laser skin resurfacing has nearly replaced more traditional methods of superficial skin rejuvenation. Post-treatment erythema is the most common side effect of this method of skin resurfacing. Sublethal thermal damage to th ... Full text Link to item Cite

Grover's disease (transient acantholytic dermatosis): relationship of acantholysis to acrosyringia.

Journal article J Cutan Pathol · November 1998 Transient acantholytic dermatosis is often associated with excessive sweating, fever, and bed confinement. The pathogenesis of this disease has been postulated to be poral occlusion of damaged eccrine intraepidermal ducts. Histological and immunohistochemi ... Full text Link to item Cite

Cutaneous Langerhans cell histiocytosis of the genitalia in the elderly: a report of three cases.

Journal article J Cutan Pathol · August 1998 Langerhans cell histiocytosis (LCH) is a disease with a broad spectrum of clinical presentations. All of the variants have in common the proliferation of cells which are morphologically, biochemically, and immunophenotypically indistinguishable from Langer ... Full text Link to item Cite

Atypical cells in radiation dermatitis express factor XIIIa.

Journal article Am J Dermatopathol · August 1998 Dendritic cells that express factor XIIIa are present in the normal dermis and are increased in a variety of pathologic conditions. Atypical dermal cells are often seen in biopsy specimens of skin that has been previously irradiated. We sought to determine ... Full text Link to item Cite

Role of histology in providing prognostic information in mycosis fungoides.

Journal article J Cutan Pathol · July 1998 Many patients who present with patch and early plaque stage mycosis fungoides follow an indolent course and survive for many years following diagnosis. A certain subset of patients, however, have rapidly progressive disease leading to accelerated demise. W ... Full text Link to item Cite

Immunophenotyping of a sarcoidal granuloma in a scar, a manifestation of a possible autoimmune process.

Journal article J Cutan Med Surg · July 1998 BACKGROUND: Old scars rarely develop sarcoid lesions. To determine whether the immunophenotype of the cellular infiltrate found in sarcoid in scarred skin resembled that seen in sardoidosis, we performed routine staining with hematoxylin and eosin, as well ... Full text Link to item Cite

Cutaneous epithelioid angioleiomyoma.

Journal article Am J Dermatopathol · April 1998 We describe an unusual dermal neoplasm with epithelioid morphology. A 44-year-old man presented with a solitary, tender, 4-mm nodule on the leg. Excisional biopsy showed several well-circumscribed dermal epithelioid tumor nodules, prominent vascularity, an ... Full text Link to item Cite

Estrogen and progesterone receptors in androgenic alopecia versus alopecia areata.

Journal article Am J Dermatopathol · April 1998 In some situations, hair growth is under hormonal control. Androgenic alopecia is characterized as hormonally driven hair loss in the genetically susceptible individual. During pregnancy, hair growth is increased, as estrogen appears to prolong the anagen ... Full text Link to item Cite

Cutaneous infiltrate of chronic lymphocytic leukemia and relationship to primary cutaneous epithelial neoplasms.

Journal article J Cutan Pathol · March 1998 Chronic lymphocytic leukemia involves the skin in a small percentage of patients and may portend an ominous prognosis in some patients. We report a series of eight biopsies from seven different patients in which the cutaneous leukemic infiltrate was confin ... Full text Link to item Cite

Role of cellular proliferation and apoptosis in the growth of xanthogranulomas.

Journal article Am J Dermatopathol · February 1998 We examined a total of 13 xanthogranulomas in order to examine the mechanism by which these lesions grow. Six xanthogranulomas from children < 2 years of age were compared with lesions from seven patients > 10 years of age. All lesions were stained with an ... Full text Link to item Cite

Evaluation of classic architectural criteria in non-mycosis fungoides cutaneous lymphomas.

Journal article Am J Dermatopathol · December 1997 Ninety-seven cases of non-mycosis fungoides (non-MF) cutaneous lymphoma were evaluated employing published criteria for the categorization of B- and T-cell cutaneous malignancies. Included in the study were 77 primary and secondary cutaneous B-cell lymphom ... Full text Link to item Cite

Intraepidermal nerve fiber expression of calcitonin gene-related peptide, vasoactive intestinal peptide and substance P in psoriasis.

Journal article Arch Dermatol Res · October 1997 In order to evaluate more fully the role of neuropeptides in the pathogenesis of psoriasis, skin biopsies were obtained from 36 patients with psoriasis to identify substance P (SP), vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide (C ... Full text Link to item Cite

Absence of human herpesvirus 8 and Epstein-Barr virus genome sequences in cutaneous epithelial neoplasms arising in immunosuppressed organ-transplant patients.

Journal article J Cutan Pathol · October 1997 Recent studies have implicated herpesvirus 8 and Epstein-Barr virus in the development of cutaneous malignancies in immunosuppressed patients. In order to examine the strength of this association, we examined 37 malignant, pre-malignant and benign cutaneou ... Full text Link to item Cite

Value of skin biopsies in assessing prognosis and progression of acute graft-versus-host disease.

Journal article Am J Surg Pathol · September 1997 Skin biopsies are commonly performed after allogeneic bone marrow transplantation (BMT) to help establish the origin of a new skin rash in a transplant recipient. Histologic criteria and a grading system for acute graft-versus-host reaction of the skin are ... Full text Link to item Cite

Differential proliferation of endothelial cells and keratinocytes in psoriasis and spongiotic dermatitis.

Journal article J Cutan Pathol · July 1997 This study used MIB-1 monoclonal antibody to quantify the proliferating keratinocytes and endothelial cells and their proliferation fractions in cases of normal skin, acute and established plaque psoriasis, and acute and chronic spongiotic dermatitis. The ... Full text Link to item Cite

UltraPulse carbon dioxide laser with CPG scanner for deepithelialization: clinical and histologic study.

Journal article Plast Reconstr Surg · June 1997 The UltraPulse carbon dioxide laser with CPG scanner was utilized to deepithelialize dermal pedicles in breast reduction inferior pedicle flaps. Clinical advantages include lack of bleeding, markedly shortened time of dissection, and excellent wound healin ... Link to item Cite

Histologic criteria for the diagnosis of erythrodermic mycosis fungoides and Sézary syndrome: a critical reappraisal.

Journal article J Cutan Pathol · May 1997 It is often difficult to make a clinical or histologic diagnosis of erythrodermic mycosis fungoides (MF) and Sezary syndrome (SS). Whereas the histologic parameters for making a diagnosis of MF with well-developed patch and plaque stage lesions are clearly ... Full text Link to item Cite

A case of extramammary Paget's disease mimicking pemphigus vulgaris on histologic examination.

Journal article Dermatology · 1997 We present a case of extramammary Paget's disease (EMP) on the vulva of a 77-year-old female that on histologic examination resembled pemphigus vulgaris. The diagnosis of EMP was established with the help of a periodic acid-Schiff stain and immunophenotypi ... Full text Link to item Cite

Immunoperoxidase techniques in the evaluation of cutaneous lymphocytic infiltrates.

Journal article Semin Cutan Med Surg · December 1996 The widespread availability of immunoperoxidase technology and antibody probes over the past 15 years has changed the discipline of dermatopathology. In no aspect is this more evident than in the microscopic study of cutaneous lymphoid infiltrates. In the ... Full text Link to item Cite

Increased proportion of aggressive-growth basal cell carcinoma in the Veterans Affairs population of Palo Alto, California.

Journal article J Am Acad Dermatol · December 1996 BACKGROUND: We have noted a high frequency of aggressive-growth basal cell carcinomas (BCCS) in our patient population. Subtypes observed with increased frequency include morpheaform, infiltrative, and micronodular. OBJECTIVE: Our purpose was to examine th ... Full text Link to item Cite

Proliferation and apoptosis within juvenile capillary hemangiomas.

Journal article Am J Dermatopathol · October 1996 Capillary hemangiomas (CH) are benign vascular neoplasms of childhood that undergo a natural course of postnatal growth followed by spontaneous involution and often complete regression. There are currently no established standards for the identification of ... Full text Link to item Cite

Evidence against a role for human T-cell lymphotrophic virus type I (HTLV-I) in the pathogenesis of American cutaneous T-cell lymphoma.

Journal article J Invest Dermatol · September 1996 We used a standard polymerase chain reaction (PCR)/Southern blot assay (sensitivity > 10(-5)) to detect human T-cell lymphotrophic virus type I (HTLV-I) proviral pX, pol, and env genes in the lesional skin of 42 American patients with cutaneous T-cell lymp ... Full text Link to item Cite

Pulsed dye laser-resistant port-wine stains.

Journal article Arch Dermatol · July 1996 Full text Link to item Cite

Differential sensitivity of estrogen/progesterone receptors and BRST-2 markers in metastatic ductal and lobular breast carcinoma to the skin.

Journal article Am J Dermatopathol · June 1996 Cutaneous metastases arising from breast carcinoma are quite common. A standard panel of immunohistochemical markers including estrogen receptor (ER), progesterone receptor (PR), and BRST-2 are frequently used in surgical pathology to identify neoplasms wi ... Full text Link to item Cite

Perivascular mast cells in urticaria pigmentosa.

Journal article J Cutan Pathol · June 1996 We have quantified perivascular mast cells in cases of urticaria pigmentosa, urticaria, and dermal hypersensitivity reactions. To facilitate reproducibility, the mast cells were counted for a precisely defined vessel unit. These vessel units were divided a ... Full text Link to item Cite

Gross cystic disease fluid protein-15 reactivity in extramammary Paget's disease with and without associated internal malignancy.

Journal article Am J Dermatopathol · April 1996 Extramammary Paget's disease (EMP) is a rare eczematoid disorder occurring mainly in apocrine-gland-bearing regions. Its histogenesis is controversial. Several investigators have proposed that EMP is a heterologous entity, with some cases representing a de ... Full text Link to item Cite

Cutaneous myiasis following travel to Belize.

Journal article Int J Dermatol · February 1996 Full text Link to item Cite

Immunohistochemistry in diagnostic dermatopathology.

Journal article J Am Acad Dermatol · February 1996 Immunopathology continues to be important in diagnostic dermatopathology. Immunopathology is an invaluable tool for assessing the tissue of origin or direction of differentiation of cells. In some cases this can result in a more precise diagnosis. This art ... Full text Link to item Cite

Reassessment of histologic parameters in the diagnosis of mycosis fungoides.

Journal article Am J Surg Pathol · December 1995 The histologic diagnosis of mycosis fungoides (MF) can be difficult to establish and is based on interpretation of numerous subtle changes, most of which may be present to some degree in many inflammatory and neoplastic cutaneous conditions. To reassess th ... Full text Link to item Cite

Progesterone receptor positivity supports hormonal control of syringomas.

Journal article J Cutan Pathol · October 1995 Syringomas may be at least partially under estrogen and/or progesterone influence, as they are more common in women and are known to proliferate at puberty. During pregnancy and the premenstrual period an increase in tumor size has also been described. We ... Full text Link to item Cite

Use of CD34 in assessing the relationship between stroma and tumor in desmoplastic keratinocytic neoplasms.

Journal article J Cutan Pathol · October 1995 It has been hypothesized that the ability for neoplastic growth of epithelial-derived neoplasms depends upon the stroma. There are currently some studies which show that the stroma surrounding basal cell carcinomas (BCC) is derived from the tumor. In contr ... Full text Link to item Cite

bcl-2 expression in melanocytic nevi. Insights into the biology of dermal maturation.

Journal article Arch Dermatol · August 1995 BACKGROUND AND DESIGN: Recently, a new category of oncogenes has been discovered that regulate programmed cell death. The bcl-2 oncogene has been found to inhibit cellular death without affecting cellular proliferation. In the skin, bcl-2 expression is lim ... Link to item Cite

bcl-2 expression in primary malignancies of the skin.

Journal article Arch Dermatol · August 1995 BACKGROUND AND DESIGN: Basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM) are the three most common malignant neoplasms that arise in the skin. Deregulation of oncogene function not infrequently leads to an increased rat ... Link to item Cite

Differentiation and clonality of lesional lymphocytes in small plaque parapsoriasis.

Journal article Arch Dermatol · March 1995 BACKGROUND: Small plaque parapsoriasis is an idiopathic chronic dermatosis characterized by patches on the trunk and extremities that are often smaller than 5 cm in diameter and that sometimes have a digitate contour. These latter cases are often referred ... Link to item Cite

Expression of bcl-2 protein and Ki-67 nuclear proliferation antigen in benign and malignant cutaneous T-cell infiltrates.

Journal article J Cutan Pathol · February 1995 The bcl-2 protein prolongs cell life by inhibiting apoptosis. Its expression has been studied in a variety of normal tissues and lymphomas but there is minimal information available concerning bcl-2 expression by benign and malignant cutaneous T-cells. The ... Full text Link to item Cite

Heterologous mesenchymal proliferation of the skin.

Journal article Dermatol Surg · February 1995 BACKGROUND: A benign cutaneous mesenchymal lesion with features of dermatofibroma, dermatomyofibroma, and lipoma is described. OBJECTIVE: An attempt is made to classify this previously undescribed entity. METHODS: Tissue sections were studied with routine ... Full text Link to item Cite

Cutaneous angiosarcoma as a second malignancy in a lymphedematous leg in a Hodgkin's disease survivor.

Journal article J Am Acad Dermatol · November 1994 Angiosarcoma is a rare and highly malignant neoplasm. Cutaneous angiosarcoma not associated with postmastectomy lymphedema is rare. There are only eight reported cases of development of cutaneous angiosarcoma in a lymphedematous extremity in a patient with ... Full text Link to item Cite

T lymphocytes bearing the gamma/delta T-cell receptor in cutaneous lesions of dermatitis herpetiformis.

Journal article J Cutan Pathol · October 1994 T lymphocytes bearing the gamma/delta T-cell receptor are a rare component of normal human GI epithelium and skin. Recently, however, an unusually high percentage of T lymphocytes with gamma/delta receptors has been described in gastrointestinal biopsies f ... Full text Link to item Cite

Apocrine cystadenoma of the vulva.

Journal article J Am Acad Dermatol · September 1994 Full text Link to item Cite

Semipermeable dressings improve epidermal barrier function in premature infants.

Journal article Pediatr Res · September 1994 Infants of less than 32 wk gestation have a defective epidermal barrier, with increased skin permeability and transepidermal water loss (TEWL). We studied the effect of a nonadhesive semipermeable dressing on the epidermal barrier of premature infants and ... Full text Link to item Cite

Benign lymphangioendothelioma.

Journal article J Am Acad Dermatol · August 1994 We describe a 40-year-old white man with a red-brown, indurated plaque on the proximal aspect of his right thigh. The lesion had been present since birth, and the patient had a 20-year clinical history of recurrent cellulitis in the same area. The histopat ... Full text Link to item Cite

bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas.

Journal article Br J Dermatol · July 1994 Trichoepitheliomas (TE) are benign follicular neoplasms which are frequently confused with basal cell carcinomas (BCC). It is important to distinguish these entities precisely, as the treatments and prognoses are different. To this end, we stained a series ... Full text Link to item Cite

CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma.

Journal article Arch Dermatol · May 1994 BACKGROUND AND DESIGN: Trichoepithelioma is a benign skin tumor with follicular differentiation, which sometimes is difficult to distinguish clinically and histologically from basal cell carcinoma. One of the most helpful differences is the histologic appe ... Link to item Cite

Immunofluorescent analysis of the basement membrane zone in lichen planus suggests destruction of the lamina lucida in bullous lesions.

Journal article J Cutan Pathol · April 1994 Lichen planus is an inflammatory dermatosis which is characterized histologically by an intense lymphocytic infiltrate at the dermal epidermal junction. This frequently results in disruption of the basement membrane zone, occasionally causing clinical blis ... Full text Link to item Cite

Risk of secondary cutaneous malignancies in patients with long-standing mycosis fungoides.

Journal article J Am Acad Dermatol · February 1994 BACKGROUND: Patients with mycosis fungoides (MF) are frequently treated with UV light and psoralen (PUVA), nitrogen mustard, and electron beam irradiation, modalities known to predispose persons to development of cutaneous malignancies. OBJECTIVE: We asses ... Full text Link to item Cite

Atypical fibroxanthoma. Multiple immunohistologic profiles.

Journal article Am J Surg Pathol · December 1993 The clinical, histologic, and immunohistochemical features of 37 cases of atypical fibroxanthoma (AFX) are presented. Patients ranged in age from 13 to 95 years (mean, 69). Thirty AFXs occurred on the head and neck, and seven lesions developed on the trunk ... Full text Link to item Cite

Dermal dendrocytes are decreased in collagenomas.

Journal article J Cutan Pathol · December 1993 Dermal dendrocytes comprise a subset of spindle-shaped cells which normally reside in the dermis. While they appear to play some role in the reticuloendothelial system, their exact functions have not been completely elucidated. In addition to their purport ... Full text Link to item Cite

The spectrum of cutaneous disease in leukemias.

Journal article J Cutan Pathol · October 1993 Cutaneous eruptions are frequent complications in the clinical course of patients with leukemia. Leukemia cutis is occasionally the cause of the eruption, but in many cases the lesions are nonleukemic. We have retrospectively selected all skin biopsies fro ... Full text Link to item Cite

Immunophenotypic analysis suggests that granuloma faciale is a gamma-interferon-mediated process.

Journal article J Cutan Pathol · October 1993 Granuloma faciale (GF) is an uncommon inflammatory dermatosis with characteristic clinical and histologic features. Very little is known about its pathogenesis. We used a battery of immunoperoxidase lymphocyte markers to study the population of hematopoiet ... Full text Link to item Cite

Cutaneous vasculitis in the newborn.

Journal article J Am Acad Dermatol · October 1993 Full text Link to item Cite

Leukemia cutis. Analysis of 50 biopsy-proven cases with an emphasis on occurrence in myelodysplastic syndromes.

Journal article Am J Clin Pathol · September 1993 The hematologic, cytomorphologic, and cytogenetic features of 50 cases of leukemia cutis (LC), occurring in 40 patients, are presented. The patients' ages ranged from 19 to 75 years (mean, 42 years). The primary hematologic diagnoses in these patients incl ... Full text Link to item Cite

Infantile (juvenile) capillary hemangioma: a tumor of heterogeneous cellular elements.

Journal article J Cutan Pathol · August 1993 Infantile (juvenile) capillary hemangiomas are vascular neoplasms which can appear quite infiltrative histologically and are characterized by cords of cells with areas of marked cellularity. While vessels can be distinguished in most cases, there are many ... Full text Link to item Cite

Alopecia universalis in an HIV-positive patient: possible insight into pathogenesis.

Journal article J Cutan Pathol · April 1993 Alopecia universalis, a variant of alopecia areata, is a disease of unknown etiology, though evidence for an autoimmune etiology continues to mount. We report an HIV-positive patient with altered T-lymphocyte subsets in whom alopecia universalis developed. ... Full text Link to item Cite

Desipramine-induced blue-gray photosensitive pigmentation.

Journal article Arch Dermatol · April 1993 BACKGROUND: Blue-gray pigmentation of the skin can be elicited by several medications. We report the first case (to our knowledge) of desipramine-induced photosensitive blue-gray pigmentation. OBSERVATIONS: Diffuse blue-gray pigmentation on sun-exposed sur ... Link to item Cite

Cutaneous nodules of Mycobacterium chelonae in an immunosuppressed patient with preexisting pulmonary colonization.

Journal article J Am Acad Dermatol · February 1993 A 30-year-old immunocompromised man with known pulmonary Mycobacterium chelonae colonization developed a systemic infection with cutaneous manifestations. The eruption consisted of multiple, nontender, subcutaneous nodules on the extremities. A diagnosis o ... Full text Link to item Cite

Preliminary analysis of histological results of Hexascan device with continuous tunable dye laser at 514 (argon) and 577 NM (yellow).

Journal article Lasers Surg Med · 1993 This histological study demonstrates that the Hexascan device combined with a continuous tunable dye laser at either 514 nm or 577 nm is able to effectively treat port wine hemangiomas. Both 514 nm and 577 nm were effective in producing almost normal looki ... Full text Link to item Cite

Differences in direct immunofluorescence staining patterns in epidermolysis bullosa acquisita and bullous pemphigoid.

Journal article J Am Acad Dermatol · November 1992 BACKGROUND: Both bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA) are characterized by linear IgG deposits along the basement membrane zone (BMZ). Although these diseases can be distinguished by special tests, the staining pattern on direc ... Full text Link to item Cite

Porokeratosis in immunosuppressed and nonimmunosuppressed patients.

Journal article Int J Dermatol · November 1992 Porokeratosis is an uncommon, inherited, autosomally dominant disorder. In the last decade association of porokeratosis and immunosuppression has been observed. In this study we carried out a comparative study between immunosuppressed and nonimmunosuppress ... Full text Link to item Cite

Porokeratosis and cardiac transplantation.

Journal article Int J Dermatol · September 1992 Full text Link to item Cite

Dysplastic nevi can be diagnosed and graded reproducibly: a longitudinal study.

Journal article J Am Acad Dermatol · September 1992 BACKGROUND: Poor interobserver reproducibility in diagnosing and grading dysplastic melanocytic nevi is often cited as evidence against the ability of pathologists to recognize such an entity. OBJECTIVE: We attempted to examine the diagnostic profiles of m ... Full text Link to item Cite

Immunohistochemical examination of lichen nitidus suggests that it is not a localized papular variant of lichen planus.

Journal article J Am Acad Dermatol · August 1992 BACKGROUND: Lichen nitidus is believed, by some, to be a variant of lichen planus, and by others to be a distinct entity. OBJECTIVE: We examined five cases of lichen nitidus with immunohistochemical reagents designed to characterize the dermal inflammatory ... Full text Link to item Cite

Congenital localized absence of the skin as a manifestation of epidermolysis bullosa.

Journal article Arch Dermatol · August 1992 BACKGROUND: Congenital localized absence of the skin has been observed in various subsets of inherited epidermolysis bullosa. Through electron microscopy and immunomapping, we attempt to clarify the relationship of congenital localized absence of the skin ... Link to item Cite

Mucoepidermoid carcinoma metastatic to the skin. An histologic mimic of a primary sweat gland carcinoma.

Journal article J Dermatol Surg Oncol · May 1992 Mucoepidermoid carcinomas are tumors that usually arise from salivary glands and have a characteristic histologic pattern of atypical squamous cells showing focal mucin production. Mucoepidermoid carcinomas are uncommon neoplasms that metastasize most comm ... Full text Link to item Cite

Acute cutaneous graft versus host disease: a clinicopathologic and immunophenotypic study.

Journal article Int J Dermatol · April 1992 Acute graft versus host disease (GVHD) is a major complication of bone marrow transplantation. This study was undertaken to characterize the histopathologic alterations in early lesions of GVHD and to improve our understanding about the disease process. Hi ... Full text Link to item Cite

A case of Woringer-Kolopp disease with Ki-1 (CD30) + cytotoxic/suppressor cells.

Journal article Arch Dermatol · April 1992 BACKGROUND: Woringer-Kolopp (W-K) disease is a rare, localized, histologically malignant, but clinically indolent lymphoproliferative disorder. Most authors have regarded W-K disease as a variant of mycosis fungoides. However, a recent case suggests that W ... Link to item Cite

Paraneoplastic pemphigus with autoantibody deposition in bronchial epithelium after autologous bone marrow transplantation.

Journal article JAMA · March 18, 1992 Paraneoplastic pemphigus is a newly described syndrome in which patients have a severe mucocutaneous eruption with clinical features reminiscent of both erythema multiforme major (Stevens-Johnson syndrome) and pemphigus vulgaris, in association with non-Ho ... Link to item Cite

Restrictive dermopathy. Report of two affected siblings and a review of the literature.

Journal article Arch Dermatol · February 1992 BACKGROUND: Restrictive dermopathy is a lethal genetic disorder consisting of abnormally tight skin, generalized joint contractures, distinctive facies, and pulmonary hypoplasia. Autosomal recessive inheritance has been suggested based on multiply affected ... Full text Link to item Cite

Pigmented purpuric eruptions: immunopathologic studies supportive of a common immunophenotype.

Journal article J Cutan Pathol · December 1991 Traditionally, the pigmented purpuric eruptions (PPE) have been subdivided into four histologic categories, based upon variations in histologic pattern and clinical morphologies. In recent years, it has become apparent that the lesions behave similarly, an ... Full text Link to item Cite

HMB-45 monoclonal antibody recognizes an inducible and reversible melanocyte cytoplasmic protein.

Journal article J Cutan Pathol · October 1991 HMB-45 is a monoclonal antibody directed against human melanoma cells and which stains epidermal and dermal melanoma cells, the junctional components of common and dysplastic melanocytic nevi, and melanocytes in fetal skin. In addition, melanocytes in a va ... Full text Link to item Cite

Detection of cytokine-induced protein gamma-immune protein-10 (gamma-IP10) in atypical melanocytic proliferations.

Journal article J Am Acad Dermatol · October 1991 gamma-Immune protein-10 (gamma-IP10) is a cytokine whose expression has been shown to be induced by interferon-gamma. It is a member of a group of closely related cytokines (e.g., interleukin 8 and platelet factor 4) with chemotactic properties. gamma-IP10 ... Full text Link to item Cite

Benign cutaneous polyarteritis nodosa. Relationship to systemic polyarteritis nodosa and to hepatitis B infection.

Journal article Arch Dermatol · October 1991 Benign cutaneous polyarteritis nodosa has been described as having a benign course in contrast to that of systemic classic polyarteritis nodosa. We tested the hypothesis that this histologic distinction is false by reviewing nine consecutive cases with the ... Link to item Cite

Diabetes impairs the late inflammatory response to wound healing.

Journal article J Surg Res · April 1991 Diabetes mellitus is recognized as a risk factor for compromised wound healing. This study examines leukocyte infiltration and the appearance of tumor necrosis factor-alpha (TNF) and IL-6 in wound chambers implanted in normal and streptozotocin-induced dia ... Full text Link to item Cite

Fixed drug eruptions: evidence for a cytokine-mediated process.

Journal article J Cutan Pathol · February 1991 Fixed drug eruptions (FDE) are immunologic reactions to drugs which produce erythematous plaques or blisters that characteristically recur at the same cutaneous sites with repeated antigenic challenges. While a detailed pathogenesis of these lesions remain ... Full text Link to item Cite

Balloon cell transformation in multiple dysplastic nevi.

Journal article J Am Acad Dermatol · February 1991 Full text Link to item Cite

Detection of the interferon-gamma-induced protein 10 in psoriasiform dermatitis of acquired immunodeficiency syndrome.

Journal article Arch Dermatol · November 1990 Interferon-gamma-induced protein 10 is a 10-kd protein produced by human keratinocytes following an exposure to interferon gamma. Keratinocytes within psoriatic plaques and within delayed-type hypersensitivity reactions have been shown to stain strongly wi ... Link to item Cite

Neurofibromas and neurotized melanocytic nevi are immunohistochemically distinct neoplasms.

Journal article Am J Dermatopathol · June 1990 Neurofibromas are often clinically, as well as histologically, indistinguishable from completely neurotized melanocytic nevi. We tested the hypothesis that immunologic markers would differentiate the perineural fibroblasts and Schwann cells of neurofibroma ... Full text Link to item Cite

Immunohistochemical demonstration of factor XIIIa expression in neurofibromas. A practical means of differentiating these tumors from neurotized melanocytic nevi and schwannomas.

Journal article Arch Dermatol · April 1990 Neurofibromas, schwannomas, and neurotized melanocytic nevi may closely resemble one another at the light microscopic level. We studied 10 neurofibromas, 10 schwannomas, and 10 partially neurotized melanocytic nevi immunohistochemically using an antibody d ... Link to item Cite

The natural history of vasculitis. What the histology tells us about pathogenesis.

Journal article Arch Dermatol · January 1990 While histopathologic analysis may offer some clues as to the pathogenesis of vasculitis, observations must be interpreted with caution, as there is considerable overlap in the histologic pattern. In most cases, a predominantly neutrophilic vasculitis affe ... Link to item Cite

Xanthomatous infiltrate of the face.

Journal article J Cutan Pathol · October 1989 We report 2 cases which shared an unusual histopathologic pattern of a xanthomatous infiltrate occurring on the nose. Both patients were women in their fifth decade. Each presented to the dermatology clinic with multiple soft, flesh-colored papules, up to ... Full text Link to item Cite

HMB-45 staining of dysplastic nevi. Support for a spectrum of progression toward melanoma.

Journal article Am J Surg Pathol · August 1989 Dysplastic nevi are melanocytic tumors that occupy intermediate positions in the spectrum of melanocytic proliferations. Although they are invariably cured if completely excised, their biologic potential if left untreated is unknown. We examined a series o ... Full text Link to item Cite

Reducing adult phlebotomy blood loss with the use of pediatric-sized blood collection tubes.

Journal article Am J Clin Pathol · June 1989 The feasibility of collecting smaller blood volumes during phlebotomy for diagnostic laboratory testing was evaluated by substituting pediatric-size for adult-size blood collection tubes. The volume of blood drawn with the use of pediatric-size tubes from ... Full text Link to item Cite

HMB-45 recognizes stimulated melanocytes.

Journal article J Cutan Pathol · April 1989 A monoclonal antibody (HMB-45) was previously reported to bind to melanoma cells, and the junctional component of nevus cells, but not to normal adult melanocytes. We have tested HMB-45 binding in several conditions under which melanocyte stimulation might ... Full text Link to item Cite

Keratinocyte protein expression in rapidly regenerating epidermis following laser-induced thermal injury.

Journal article Lasers Surg Med · 1989 We examined 20 punch biopsies taken from five patients at varying intervals following CO2 laser-induced thermal injury. The regenerating epidermis was studied with monoclonal antibodies AE1 and AE3 (directed against low and high molecular weight keratins), ... Full text Link to item Cite

Low-fluence carbon dioxide laser irradiation of lentigines.

Journal article Arch Dermatol · August 1988 Low-fluence carbon dioxide (CO2) laser irradiation of skin has previously been shown to induce damage limited primarily to the epidermis. To evaluate whether this technique was therapeutically effective for pigmented epidermal lesions, ten lentigines cause ... Link to item Cite

Unexpected vascular response to epinephrine in port wine stains.

Journal article Plast Reconstr Surg · December 1987 Success of argon laser therapy as a therapeutic modality for port wine stains has been correlated with the degree of vascular congestion within the lesions. Epinephrine causes vasoconstriction and erythrocyte stasis within normally innervated vessels. We t ... Full text Link to item Cite

Disulfiram and fulminant hepatitis.

Journal article Dig Dis Sci · September 1987 Full text Link to item Cite

Port-wine stains: a new hypothesis.

Journal article J Am Acad Dermatol · July 1987 Port-wine stains have been shown to be derived from a progressive ectasia of the superficial vascular plexus. Recent studies have documented a marked decrease in nerves associated with these abnormal vessels. It is suggested that this nerve loss is primari ... Full text Link to item Cite

Pathogenesis of port wine stains. A new hypothesis.

Journal article Med Hypotheses · April 1987 Port wine stains have been shown to be lesions formed by the progressive dilatation of vessels within the superficial cutaneous vascular plexus. Previous investigators have been unable to define abnormalities of vessel structure or perivascular stromal tis ... Full text Link to item Cite

Phlebotomy for diagnostic laboratory tests in adults. Pattern of use and effect on transfusion requirements.

Journal article N Engl J Med · May 8, 1986 Although anemia is a frequently observed complication of phlebotomies for laboratory tests in neonates, this problem has received little attention in adult populations. We analyzed the phlebotomy records of 100 hospitalized patients and found that 50 patie ... Full text Link to item Cite

Port-wine stains. A disease of altered neural modulation of blood vessels?

Journal article Arch Dermatol · February 1986 Port-wine stains result from a progressive ectasia of the cutaneous superficial vascular plexus. One hypothesis for the pathogenesis of this lesion is an abnormal neural regulation of blood flow. Biopsy specimens of 11 port-wine stains, seven hemangiomas, ... Full text Link to item Cite

Keratoacanthoma and squamous cell carcinoma of the skin: immunohistochemical localization of involucrin and keratin proteins.

Journal article J Am Acad Dermatol · February 1986 Fifteen keratoacanthomas and fifteen squamous cell carcinomas of the skin were examined by immunoperoxidase methods for involucrin and both 45- and 63-kilodalton keratins. Keratoacanthomas showed a relatively homogeneous staining pattern for involucrin; al ... Full text Link to item Cite

Alpha 1-antitrypsin and lysozyme in fibrous papules and angiofibromas.

Journal article J Am Acad Dermatol · January 1985 The large stellate and polygonal cells observed in eleven fibrous papules and two angiofibromas were examined immunohistochemically for alpha 1-antitrypsin and lysozyme. The positive findings suggest that these cells are related to histiocytes rather than ... Full text Link to item Cite